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N-Desmethyldauricine Induces Autophagic Cell Death in Apoptosis-Defective Cells via Ca(2+) Mobilization.
Law BYK, Mok SWF, Chen J, Michelangeli F, Jiang ZH, Han Y, Qu YQ, Qiu ACL, Xu SW, Xue WW, Yao XJ, Gao JY, Javed MU, Coghi P, Liu L, Wong VKW. Law BYK, et al. Front Pharmacol. 2017 Jun 16;8:388. doi: 10.3389/fphar.2017.00388. eCollection 2017. Front Pharmacol. 2017. PMID: 28670281 Free PMC article.
By computational virtual docking analysis, biochemical assays, and advanced live-cell imaging techniques, we have identified N-desmethyldauricine (LP-4), isolated from rhizoma of Menispermum dauricum DC as a novel inducer of autophagy. ...
By computational virtual docking analysis, biochemical assays, and advanced live-cell imaging techniques, we have identified N-des …
A sensitive and selective UPLC-MS/MS method for simultaneous determination of 10 alkaloids from Rhizoma Menispermi in rat plasma and its application to a pharmacokinetic study.
Wei J, Fang L, Liang X, Su D, Guo X. Wei J, et al. Talanta. 2015 Nov 1;144:662-70. doi: 10.1016/j.talanta.2015.07.023. Epub 2015 Jul 8. Talanta. 2015. PMID: 26452875
A sensitive and selective liquid chromatography-tandem mass spectrometry method has been developed and validated for simultaneous quantitation of 10 alkaloids (dauricine, daurisoline, N-desmethyldauricine, dauricicoline, dauriporphinoline, bianfugecine, dauricoside, …
A sensitive and selective liquid chromatography-tandem mass spectrometry method has been developed and validated for simultaneous quantitati …
[A new alkaloid from Menispermum dauricum DC--N-desmethyldauricine].
Pan XP. Pan XP. Yao Xue Xue Bao. 1992;27(10):788-91. Yao Xue Xue Bao. 1992. PMID: 1293929 Chinese.
The new alkaloid is an unstable white powder: Based on spectrometric analysis (UV, IR, FAB-MS and 1HNMR) and N-methylation which offered dauricine dimethiodide (V), the structure was elucidated as RR, N-desmethyldauricine (II), which was isolated for the first time …
The new alkaloid is an unstable white powder: Based on spectrometric analysis (UV, IR, FAB-MS and 1HNMR) and N-methylation which offered dau …