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Toxicity of N-(3,5-dichlorophenyl)succinimide and metabolites to rat renal proximal tubules and mitochondria.
Aleo MD, Rankin GO, Cross TJ, Schnellmann RG. Aleo MD, et al. Chem Biol Interact. 1991;78(1):109-21. doi: 10.1016/0009-2797(91)90107-i. Chem Biol Interact. 1991. PMID: 2009578
This study examined the toxicity of NDPS, its known metabolites N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS), N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (NDHSA), N-(3,5-dichlorophenyl)malonamic acid (DMA), N-(3,5- …
This study examined the toxicity of NDPS, its known metabolites N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS), N-(3,5 …
Acute nephrotoxicity induced by N-(3,5-dichlorophenyl)-3-hydroxysuccinamic acid in Fischer 344 rats.
Rankin GO, Shih H, Teets VJ, Nicoll DW, Brown PI. Rankin GO, et al. Toxicol Lett. 1989 Sep;48(3):217-23. doi: 10.1016/0378-4274(89)90047-7. Toxicol Lett. 1989. PMID: 2781590
The purpose of this study was to examine the nephrotoxic potential of N-(3,5-dichlorophenyl)-3-hydroxysuccinamic acid (3-NDHSA), a potential metabolite of NDPS and a positional isomer of N-(3,5-dichlorophenyl)-2-hydroxysuccinamic …
The purpose of this study was to examine the nephrotoxic potential of N-(3,5-dichlorophenyl)-3-hydroxysuccinamic acid (3-NDHSA), a po …
Role of stereochemistry in N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity.
Rankin GO, Sun H, Anestis DK, Noe O 2nd, Ball JG, Valentovic MA, Brown PI, Hubbard JL. Rankin GO, et al. Toxicology. 2001 Nov 30;168(3):241-50. doi: 10.1016/s0300-483x(01)00476-0. Toxicology. 2001. PMID: 11684321
Oxidation of the succinimide ring in NDPS yields the nephrotoxic metabolites N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and its hydrolysis product N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA). The oxidation of …
Oxidation of the succinimide ring in NDPS yields the nephrotoxic metabolites N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and its hydr …
Effect of buthionine sulfoximine on N-(3,5-dichlorophenyl)-2-hydroxysuccinimide and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid nephrotoxicity.
Rankin GO, Teets VJ, Nicoll DW, Brown PI. Rankin GO, et al. Toxicol Lett. 1991 Aug;57(3):297-308. doi: 10.1016/0378-4274(91)90204-j. Toxicol Lett. 1991. PMID: 1882389
Two NDPS metabolites, N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (NDHSA) previously have been shown to be more potent nephrotoxicants than NDPS. ...
Two NDPS metabolites, N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-dichlorophenyl)-2- …
Gender differences in acute N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity in Fischer 344 rats.
Hong SK, Anestis DK, Valentovic MA, Ball JG, Brown PI, Wang RT, Rankin GO. Hong SK, et al. J Toxicol Environ Health A. 1998 Aug 21;54(8):613-32. doi: 10.1080/009841098158647. J Toxicol Environ Health A. 1998. PMID: 9726783
The purpose of this study was to examine the nephrotoxic potential of the two NDPS metabolites N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) in age-matched male and …
The purpose of this study was to examine the nephrotoxic potential of the two NDPS metabolites N-(3,5-dichlorophenyl)-2-hydroxysuccinimide ( …
Sodium sulfate potentiates N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity in the Fischer 344 rat.
Hong SK, Anestis DK, Ball JG, Valentovic MA, Brown PI, Rankin GO. Hong SK, et al. Toxicology. 1999 Nov 15;138(3):165-74. doi: 10.1016/s0300-483x(99)00102-x. Toxicology. 1999. PMID: 10593507
Previous studies have shown that NDPS induces nephrotoxicity following oxidation of the succinimide ring to form N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and the hydrolysis product of NDHS, N-(3,5-dichlorophenyl)-2-hydroxysuccinamic …
Previous studies have shown that NDPS induces nephrotoxicity following oxidation of the succinimide ring to form N-(3,5-dichlorophenyl)-2-hy …
Role of leukotrienes in N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in male Fischer 344 rats.
Rankin GO, Hong SK, Anestis DK, Ball JG, Valentovic MA, Graffeo VA. Rankin GO, et al. Toxicology. 2012 Oct 9;300(1-2):92-9. doi: 10.1016/j.tox.2012.06.003. Epub 2012 Jun 15. Toxicology. 2012. PMID: 22706168 Free PMC article.
Male Fischer 344 rats (4 rats/group) were administered diethylcarbamazine (DEC; 250 or 500mg/kg, ip), an inhibitor of LTA(4) synthesis, 1h before NDPS (0.4mmol/kg, ip), N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS, 0.1, 0.2, or 0.4mmol/kg, ip), or N-(3,5 …
Male Fischer 344 rats (4 rats/group) were administered diethylcarbamazine (DEC; 250 or 500mg/kg, ip), an inhibitor of LTA(4) synthesis, 1h b …
Gender differences in the potentiation of N-(3,5-dichlorophenyl)succinimide metabolite nephrotoxicity by phenobarbital.
Hong SK, Anestis DK, Valentovic MA, Ball JG, Brown PI, Rankin GO. Hong SK, et al. J Toxicol Environ Health A. 2001 Oct 12;64(3):241-56. doi: 10.1080/15287390152543717. J Toxicol Environ Health A. 2001. PMID: 11594702
The purpose of this study was to determine the ability of phenobarbital pretreatment to potentiate (1) NDHS nephrotoxicity in female rats and (2) N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA, a nephrotoxic metabolite of …
The purpose of this study was to determine the ability of phenobarbital pretreatment to potentiate (1) NDHS nephrotoxicity in female rats an …
Transamination in the metabolism of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide in rats.
Cui D, Rankin GO, Harvison PJ. Cui D, et al. Drug Metab Dispos. 2005 Dec;33(12):1765-70. doi: 10.1124/dmd.105.006593. Epub 2005 Sep 20. Drug Metab Dispos. 2005. PMID: 16174804
Using liquid chromatography-tandem mass spectrometry and synthetic standards, the two metabolites were identified as N-(3,5-dichlorophenyl)-2-aminosuccinamic acid (2-NDASA) and its N-acetylated derivative (N-acetyl-2-NDASA). ...Incubations were carried out in rat liver and …
Using liquid chromatography-tandem mass spectrometry and synthetic standards, the two metabolites were identified as N-(3,5-dichlorophenyl)- …
N-(3,5-dichlorophenyl)succinimide nephrotoxicity: evidence against the formation of nephrotoxic glutathione or cysteine conjugates.
Rankin GO, Shih HC, Teets VJ, Yang DJ, Nicoll DW, Brown PI. Rankin GO, et al. Toxicology. 1991;68(3):307-25. doi: 10.1016/0300-483x(91)90077-e. Toxicology. 1991. PMID: 1680251
In a third experiment, the ability of the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid (AOAA) (0.5 mmol/kg, i.p.) to alter the nephrotoxicity induced by two NDPS metabolites, N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) or N-(3,5- …
In a third experiment, the ability of the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid (AOAA) (0.5 mmol/kg, i.p.) to a …
23 results