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Quantitative Analysis of Methylated Adenosine Modifications Revealed Increased Levels of N 6-Methyladenosine (m6A) and N 6,2'-O-Dimethyladenosine (m6Am) in Serum From Colorectal Cancer and Gastric Cancer Patients.
Hu Y, Fang Z, Mu J, Huang Y, Zheng S, Yuan Y, Guo C. Hu Y, et al. Front Cell Dev Biol. 2021 Jul 26;9:694673. doi: 10.3389/fcell.2021.694673. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34381776 Free PMC article.
Methylated adenosine (A) modifications such as N (6)-methyladenosine (m(6)A), N (1)-methyladenosine (m(1)A), 2'-O-methyladenosine (Am), N (6),2'-O-dimethyladenosine (m(6)Am), and N (6),N (6)-dimethyladenosine (m(6) (2)A) are typical epigenetic m …
Methylated adenosine (A) modifications such as N (6)-methyladenosine (m(6)A), N (1)-methyladenosine (m(1)A), 2'-O-methyladenosine (Am), N (6 …
HILIC-MS/MS for the Determination of Methylated Adenine Nucleosides in Human Urine.
Guo C, Hu Y, Cao X, Wang Y. Guo C, et al. Anal Chem. 2021 Dec 28;93(51):17060-17068. doi: 10.1021/acs.analchem.1c03829. Epub 2021 Dec 13. Anal Chem. 2021. PMID: 34902250 Free PMC article.
N(6)-methyladenosine (m(6)A), 2'-O-methyladenosine (A(m)), N(6),2'-O-dimethyladenosine (m(6)A(m)), and N(6),N(6)-dimethyladenosine (m(6)(2)A) are common RNA modifications. ...
N(6)-methyladenosine (m(6)A), 2'-O-methyladenosine (A(m)), N(6),2'-O-dimethyladenosine (m(6)A(m)), and N(6),N(6) …
Determination of adenosine and its modifications in urine and plasma from breast cancer patients by hydrophilic interaction liquid chromatography-tandem mass spectrometry.
Zhang X, Hu Y, Hong X, Wang M, Fang Z, Cao X, Jiang K, Guo C. Zhang X, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Oct 15;1209:123428. doi: 10.1016/j.jchromb.2022.123428. Epub 2022 Aug 25. J Chromatogr B Analyt Technol Biomed Life Sci. 2022. PMID: 36041348
RNA modifications have been revealed to be essential in many biological activities, and their disorders are associated with various human diseases, including cancers. 2'-O-methyladenosine (A(m)), N(1)-methyladenosine (m(1)A), N(6)-methyladenosine (m(6)A), N(6),2'-O-dimethyladenos …
RNA modifications have been revealed to be essential in many biological activities, and their disorders are associated with various human di …
Methylation of the nucleobases in RNA oligonucleotides mediates duplex-hairpin conversion.
Micura R, Pils W, Höbartner C, Grubmayr K, Ebert MO, Jaun B. Micura R, et al. Nucleic Acids Res. 2001 Oct 1;29(19):3997-4005. doi: 10.1093/nar/29.19.3997. Nucleic Acids Res. 2001. PMID: 11574682 Free PMC article.
It is shown that this sequence is forced to adopt a hairpin conformation if one of the central 6 nt is replaced by the corresponding methylated nucleotide, such as 1-methylguanosine N(2),N(2)-dimethylguanosine, N(6),N(6)-dimethyladenosine (m(6)( …
It is shown that this sequence is forced to adopt a hairpin conformation if one of the central 6 nt is replaced by the corresponding methyla …
AlkB-Facilitated Demethylation Enables Quantitative and Site-Specific Detection of Dual Methylation of Adenosine in RNA.
Guo X, Xie NB, Chen W, Ji TT, Xiong J, Feng T, Wang M, Zhang S, Gu SY, Feng YQ, Yuan BF. Guo X, et al. Anal Chem. 2024 Jan 16;96(2):847-855. doi: 10.1021/acs.analchem.3c04457. Epub 2023 Dec 30. Anal Chem. 2024. PMID: 38159051
RNA molecules undergo various chemical modifications that play critical roles in a wide range of biological processes. N(6),N(6)-Dimethyladenosine (m(6,6)A) is a conserved RNA modification and is essential for the processing of rRNA. ...
RNA molecules undergo various chemical modifications that play critical roles in a wide range of biological processes. N(6), …
Control of substrate specificity by a single active site residue of the KsgA methyltransferase.
O'Farrell HC, Musayev FN, Scarsdale JN, Rife JP. O'Farrell HC, et al. Biochemistry. 2012 Jan 10;51(1):466-74. doi: 10.1021/bi201539j. Epub 2011 Dec 22. Biochemistry. 2012. PMID: 22142337
This means that the active site pocket must accept both adenosine and N(6)-methyladenosine as substrates to catalyze formation of the final product N(6),N(6)-dimethyladenosine. KsgA is related to DNA adenosine methyltransferases, which transfer …
This means that the active site pocket must accept both adenosine and N(6)-methyladenosine as substrates to catalyze formation of the final …
28 results