5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
J Med Chem. 2000 Nov 30;43(24):4647-56. doi: 10.1021/jm000975u.
J Med Chem. 2000.
PMID: 11101356
Nucleosides 5a,b,d-h were selectively converted to the corresponding 5'-monophosphates 6a,b,d-h with the aid of the wheat shoot phosphotransferase system. ...Thymidylate synthase inhibition was studied with two forms of the enzyme differing in sensitivities toward 5-fluoro …
Nucleosides 5a,b,d-h were selectively converted to the corresponding 5'-monophosphates 6a,b,d-h with the aid of the wheat shoot phosp …