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A pharmacokinetic and pharmacodynamic investigation of Modufolin compared to Isovorin after single dose intravenous administration to patients with colon cancer: a randomized study.
Wettergren Y, Taflin H, Odin E, Kodeda K, Derwinger K. Wettergren Y, et al. Cancer Chemother Pharmacol. 2015 Jan;75(1):37-47. doi: 10.1007/s00280-014-2611-9. Epub 2014 Oct 24. Cancer Chemother Pharmacol. 2015. PMID: 25342290 Free PMC article. Clinical Trial.
MethyleneTHF has recently been developed into the stable, distributable drug, Modufolin. The aim was to compare the concentration of folate metabolites in tumor, mucosa, and plasma of patients with colon cancer after administration of Modufolin or Isovorin (levo-leu …
MethyleneTHF has recently been developed into the stable, distributable drug, Modufolin. The aim was to compare the concentration of …
Phase 1 dose de-escalation trial of the endogenous folate [6R]-5,10-methylene tetrahydrofolate in combination with fixed-dose pemetrexed as neoadjuvant therapy in patients with resectable rectal cancer.
Gustavsson B, Carlsson G, Swartling T, Kurlberg G, Derwinger K, Björkqvist H, Odin E, Gibson F. Gustavsson B, et al. Invest New Drugs. 2015 Oct;33(5):1078-85. doi: 10.1007/s10637-015-0272-0. Epub 2015 Jul 21. Invest New Drugs. 2015. PMID: 26189513 Free PMC article. Clinical Trial.
BACKGROUND: Modufolin ([6R]-5,10-methylene tetrahydrofolate; [6R]-MTHF) is an endogenous biomodulator that is being developed as an alternative to leucovorin, a folate prodrug used in the treatment of colorectal cancer. ...
BACKGROUND: Modufolin ([6R]-5,10-methylene tetrahydrofolate; [6R]-MTHF) is an endogenous biomodulator that is being developed as an a …