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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 2
1983 1
1984 1
1985 1
1986 3
1988 1
1990 1
1991 3
1992 3
1993 1
1994 1
1996 2
1997 1
2000 1
2002 1
2003 2
2006 1
2007 1
2021 1
2022 2
2023 1
2024 0

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29 results

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Page 1
Opioid toxicity: histamine, hypersensitivity, and MRGPRX2.
Baldo BA, Pham NH. Baldo BA, et al. Arch Toxicol. 2023 Feb;97(2):359-375. doi: 10.1007/s00204-022-03402-2. Epub 2022 Nov 7. Arch Toxicol. 2023. PMID: 36344690 Review.
Opioids including morphine, codeine, dextromethorphan and metazocine as well as endogenous prodynorphin opioid peptides activate MRGPRX2 at concentrations causing mast cell degranulation. ...
Opioids including morphine, codeine, dextromethorphan and metazocine as well as endogenous prodynorphin opioid peptides activate MRGP …
Pharmacological profiles of opioid ligands at kappa opioid receptors.
Gharagozlou P, Hashemi E, DeLorey TM, Clark JD, Lameh J. Gharagozlou P, et al. BMC Pharmacol. 2006 Jan 25;6:3. doi: 10.1186/1471-2210-6-3. BMC Pharmacol. 2006. PMID: 16433932 Free PMC article.
The absolute levels of inhibition of cAMP production by each ligand was used to describe the rank order of intrinsic activity of the agonists; fentanyl = lofentanil > or = hydromorphone = morphine = nalorphine > or = etorphine > or = xorphanol > or = metazocine …
The absolute levels of inhibition of cAMP production by each ligand was used to describe the rank order of intrinsic activity of the agonist …
Intermediate efficacy mu opioids: examination of their morphine-like stimulus effects and response rate-decreasing effects in morphine-tolerant rats.
Picker MJ, Craft RM, Negus SS, Powell KR, Mattox SR, Jones SR, Hargrove BK, Dykstra LA. Picker MJ, et al. J Pharmacol Exp Ther. 1992 Nov;263(2):668-81. J Pharmacol Exp Ther. 1992. PMID: 1331411
In the drug discrimination procedure, (-)-metazocine, proxorphan and (-)-pentazocine produced high levels of substitution for the 3-MS stimulus and intermediate levels for the 10-MS stimulus. ...The results of the present study suggest that the relative order of intrinsic …
In the drug discrimination procedure, (-)-metazocine, proxorphan and (-)-pentazocine produced high levels of substitution for the 3-M …
Interactions Between Opioids and Dextroamphetamine on Locomotor Activity: Influence of an Opioid's Relative Efficacy at the Mu Receptor.
Smith MA, Ballard SL, Ballesteros CF, Bonge SA, Casimir AT, Childs LM, Feinstein MA, Griffith AK, Johansen AN, Lee D, Mauser AC, Moses CM, Robertson IJ, Robles JU, Strickland JC, Walters ME, Yoo SJ. Smith MA, et al. Front Psychiatry. 2022 Jan 5;12:790471. doi: 10.3389/fpsyt.2021.790471. eCollection 2021. Front Psychiatry. 2022. PMID: 35069292 Free PMC article.
Levorphanol, buprenorphine, butorphanol, nalbuphine, (-)-pentazocine, (-)-metazocine, (-)-cyclazocine, (-)-NANM, and nalorphine increased the locomotor effects of d-amphetamine in either an additive or greater-than-additive manner according to an effect-additive model. ...
Levorphanol, buprenorphine, butorphanol, nalbuphine, (-)-pentazocine, (-)-metazocine, (-)-cyclazocine, (-)-NANM, and nalorphine incre …
Interactions between the discriminative stimulus effects of mu and kappa opioid agonists in the squirrel monkey.
Negus SS, Picker MJ, Dykstra LA. Negus SS, et al. J Pharmacol Exp Ther. 1991 Jan;256(1):149-58. J Pharmacol Exp Ther. 1991. PMID: 1846412
In the fentanyl-trained monkeys, fentanyl, as well as the less selective mu agonists buprenorphine and (-)-metazocine, produced dose-dependent and complete substitution for the training stimulus. ...Fentanyl produced neither agonist nor antagonist effects in the U50,488-tr …
In the fentanyl-trained monkeys, fentanyl, as well as the less selective mu agonists buprenorphine and (-)-metazocine, produced dose- …
Synthesis and biological evaluation of a metazocine-containing enkephalinamide. Evidence for nonidentical roles of the tyramine moiety in opiates and opioid peptides.
Ramakrishnan K, Portoghese PS. Ramakrishnan K, et al. J Med Chem. 1982 Dec;25(12):1423-7. doi: 10.1021/jm00354a006. J Med Chem. 1982. PMID: 7154002
In an effort to test the hypothesis that the tyramine moiety present in opiates and in opioid peptides plays an identical functional role at opioid receptors, a hybrid enkephalinamide (3) that contains (-)-metazocine (4a) in place of Tyr was synthesized. It was found that …
In an effort to test the hypothesis that the tyramine moiety present in opiates and in opioid peptides plays an identical functional role at …
Activity of opioid ligands in cells expressing cloned mu opioid receptors.
Gharagozlou P, Demirci H, David Clark J, Lameh J. Gharagozlou P, et al. BMC Pharmacol. 2003 Jan 4;3:1. doi: 10.1186/1471-2210-3-1. Epub 2003 Jan 4. BMC Pharmacol. 2003. PMID: 12513698 Free PMC article.
The rank order of efficacy of the agonists was fentanyl = hydromorphone = beta-endorphin > etorphine = lofentanil = butorphanol = morphine = nalbuphine = nalorphine > cyclazocine = dezocine = metazocine >or= xorphanol. The rank order of potency of these ligands wa …
The rank order of efficacy of the agonists was fentanyl = hydromorphone = beta-endorphin > etorphine = lofentanil = butorphanol = morphin …
Catalytic enantioselective amination of silyl enol ethers using chiral dirhodium(II) carboxylates: asymmetric formal synthesis of (-)-metazocine.
Anada M, Tanaka M, Washio T, Yamawaki M, Abe T, Hashimoto S. Anada M, et al. Org Lett. 2007 Oct 25;9(22):4559-62. doi: 10.1021/ol702019b. Epub 2007 Sep 26. Org Lett. 2007. PMID: 17894504
The effectiveness of the present catalytic protocol has been demonstrated by an asymmetric formal synthesis of (-)-metazocine....
The effectiveness of the present catalytic protocol has been demonstrated by an asymmetric formal synthesis of (-)-metazocine....
Dietary cadmium exposure alters characteristics of training, substitution, and tolerance when morphine is used as a discriminative stimulus.
Nation JR, Miller DK, Bratton GR. Nation JR, et al. Neurotoxicology. 2000 Aug;21(4):553-67. Neurotoxicology. 2000. PMID: 11022863
Additional substitution tests were conducted with increasing doses of the high efficacy mu agonist fentanyl (0.0016-0.04 mg/kg), the intermediate efficacy mu agonist (-)-metazocine (0.60-5.00 mg/kg), and the kappa agonist (+/-)-bremazocine (0.03-0.12 mg/kg). ...The results …
Additional substitution tests were conducted with increasing doses of the high efficacy mu agonist fentanyl (0.0016-0.04 mg/kg), the interme …
Pharmacological analysis of the phencyclidine-like discriminative stimulus properties of narcotic derivatives in rats.
Shannon HE. Shannon HE. J Pharmacol Exp Ther. 1982 Jul;222(1):146-51. J Pharmacol Exp Ther. 1982. PMID: 7086696
PCP-like stimulus control of behavior was produced by (in order of relative molar potency): l-cyclazocine greater than PCP greater than dl-cyclazocine greater than SKF 10,047 greater than MeO-cyclazocine greater than dextrorphan greater than d-cyclazocine. Metazocine and l …
PCP-like stimulus control of behavior was produced by (in order of relative molar potency): l-cyclazocine greater than PCP greater than dl-c …
29 results