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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1976 3
1978 4
1979 1
1980 2
1981 9
1982 1
1983 5
1984 4
1985 6
1986 10
1987 3
1988 7
1989 6
1990 7
1991 4
1992 3
1993 4
1994 8
1995 5
1996 3
1997 3
1998 5
1999 4
2000 1
2001 1
2002 3
2003 1
2004 4
2005 4
2006 5
2007 1
2008 4
2009 4
2011 3
2014 2
2015 3
2016 2
2019 2
2020 1
2021 1
2022 1
2024 0

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149 results

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Page 1
Second-generation antihistamines: a study of poisoning in children.
Verdu E, Blanc-Brisset I, Meyer G, Le Roux G, Bruneau C, Deguigne M. Verdu E, et al. Clin Toxicol (Phila). 2020 Apr;58(4):275-283. doi: 10.1080/15563650.2019.1634812. Epub 2019 Jul 4. Clin Toxicol (Phila). 2020. PMID: 31271318
The objective of this study is to use data from Poisons Centres in France to describe the toxicity profile of second-generation antihistamines for children and to compare the severity of poisoning observed from these with a first-generation antihistamine.Method: This was a retros …
The objective of this study is to use data from Poisons Centres in France to describe the toxicity profile of second-generation antihistamin …
On-the-road driving performance after use of the antihistamines mequitazine and l-mequitazine, alone and with alcohol.
van der Sluiszen NN, Vermeeren A, Jongen S, Theunissen EL, van Oers AC, Van Leeuwen CJ, Maret A, Desforges C, Delarue A, Ramaekers JG. van der Sluiszen NN, et al. Psychopharmacology (Berl). 2016 Sep;233(18):3461-9. doi: 10.1007/s00213-016-4386-7. Epub 2016 Aug 4. Psychopharmacology (Berl). 2016. PMID: 27488192 Free PMC article. Clinical Trial.
The aim of the current study was to assess the effects of l-mequitazine and mequitazine, alone and with alcohol, on driving. METHODS: Twenty-five healthy volunteers were treated with l-mequitazine 2.5, 5.0 and 10 mg, mequitazine 10 mg and placebo, alon …
The aim of the current study was to assess the effects of l-mequitazine and mequitazine, alone and with alcohol, on driving. M …
Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.
Nakamura K, Yokoi T, Kodama T, Inoue K, Nagashima K, Shimada N, Shimizu T, Kamataki T. Nakamura K, et al. J Pharmacol Exp Ther. 1998 Feb;284(2):437-42. J Pharmacol Exp Ther. 1998. PMID: 9454781
Mequitazine hydroxylase was inhibited by propranolol and quinidine. ...Inhibition of CYP3A-catalyzed midazolam 1'-hydroxylase by various histamine H1 antagonists, including mequitazine, suggested that mequitazine and some other histamine H1 antagonists could …
Mequitazine hydroxylase was inhibited by propranolol and quinidine. ...Inhibition of CYP3A-catalyzed midazolam 1'-hydroxylase by vari …
[Efficiency of mequitazine in the treatment of allergic rhinitis and chronic urticaria in children. A bibliographic systematic review].
Martín JP, Martinez HG, Pérez GL, Manzur JN. Martín JP, et al. Rev Alerg Mex. 2008 Jan-Feb;55(1):3-9. Rev Alerg Mex. 2008. PMID: 18697448 Review. Spanish.
Second generation H1 antihistamine drugs are considered first-line treatment due to their efficacy and safety. OBJECTIVE: To assess the efficacy and adverse effects of mequitazine in the treatment of these diseases. MATERIAL AND METHODS: A bibliographic systematic review w …
Second generation H1 antihistamine drugs are considered first-line treatment due to their efficacy and safety. OBJECTIVE: To assess the effi …
Asymmetric synthesis of (+)-mequitazine from quinine.
Leroux S, Larquetoux L, Nicolas M, Doris E. Leroux S, et al. Org Lett. 2011 Jul 1;13(13):3549-51. doi: 10.1021/ol2012567. Epub 2011 Jun 9. Org Lett. 2011. PMID: 21657243
The first asymmetric synthesis of the antihistaminic drug mequitazine is reported. Our approach started from quinine, a Cinchona alkaloid, whose chiral information was exploited for setting up the stereogenic center of (+)-mequitazine....
The first asymmetric synthesis of the antihistaminic drug mequitazine is reported. Our approach started from quinine, a Cinchona alka …
A dose-ranging study of the effects of mequitazine on actual driving, memory and psychomotor performance as compared to dexchlorpheniramine, cetirizine and placebo.
Theunissen EL, Vermeeren A, van Oers AC, van Maris I, Ramaekers JG. Theunissen EL, et al. Clin Exp Allergy. 2004 Feb;34(2):250-8. doi: 10.1111/j.1365-2222.2004.01874.x. Clin Exp Allergy. 2004. PMID: 14987305 Clinical Trial.
METHODS: Eighteen healthy volunteers received on separate days a single dose of 5, 10 and 15 mg mequitazine, 10 mg cetirizine, 6 mg dexchlorpheniramine and placebo. ...Cetirizine did not affect performance in any of the tasks. CONCLUSION: It was concluded that mequitazi …
METHODS: Eighteen healthy volunteers received on separate days a single dose of 5, 10 and 15 mg mequitazine, 10 mg cetirizine, 6 mg d …
Effect of titanium dioxide on photostability of solid-state mequitazine.
Kakinoki K, Yamane K, Yamamoto M, Teraoka R, Sugimoto I, Matsuda Y. Kakinoki K, et al. Chem Pharm Bull (Tokyo). 2005 Sep;53(9):1092-6. doi: 10.1248/cpb.53.1092. Chem Pharm Bull (Tokyo). 2005. PMID: 16141574 Free article.
The relationship between the apparent degradation rate constant and water vapor pressure could be clearly described by a simple power law. The major photo-degradation products of mequitazine, resulting from photocatalytic activity of TiO(2), were mequitazine-S-oxide …
The relationship between the apparent degradation rate constant and water vapor pressure could be clearly described by a simple power law. T …
Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance.
Theunissen EL, Vermeeren A, Ramaekers JG. Theunissen EL, et al. Br J Clin Pharmacol. 2006 Jan;61(1):79-86. doi: 10.1111/j.1365-2125.2005.02524.x. Br J Clin Pharmacol. 2006. PMID: 16390354 Free PMC article. Clinical Trial.
AIMS: Previous studies have demonstrated that the antihistamines mequitazine, cetirizine and dexchlorpheniramine produce mild sedation after single doses. ...Cetirizine did not impair performance on any of the tests. CONCLUSIONS: Single doses of mequitazine 10 mg an …
AIMS: Previous studies have demonstrated that the antihistamines mequitazine, cetirizine and dexchlorpheniramine produce mild sedatio …
Anti-platelet activating factor, anti-leukotriene D4 and some other antiallergic activities of mequitazine.
Tasaka K, Akagi M, Mio M, Izushi K, Aoki I. Tasaka K, et al. Arzneimittelforschung. 1990 Oct;40(10):1092-7. Arzneimittelforschung. 1990. PMID: 1705425
Mequitazine (0.5-50 nmol/l) also inhibited LTD4- and PAF- induced contractions of guinea pig tracheal chain. These results suggest that mequitazine possesses antagonistic activity for LTs and PAF; the effects of mequitazine against these two agonists were muc …
Mequitazine (0.5-50 nmol/l) also inhibited LTD4- and PAF- induced contractions of guinea pig tracheal chain. These results suggest th …
Effect of mequitazine on the pharmacokinetics of theophylline in asthmatic patients.
Hasegawa T, Takagi K, Kuzuya T, Nadai M, Apichartpichean R, Muraoka I. Hasegawa T, et al. Eur J Clin Pharmacol. 1990;38(3):255-8. doi: 10.1007/BF00315026. Eur J Clin Pharmacol. 1990. PMID: 2340844
The effect of an oral anti-allergic drug, mequitazine, on the pharmacokinetics of theophylline has been investigated in seven asthmatic patients. They received chronic theophylline therapy (a sustained-release theophylline tablet 200-400 mg b.d. at 12 h intervals) and coad …
The effect of an oral anti-allergic drug, mequitazine, on the pharmacokinetics of theophylline has been investigated in seven asthmat …
149 results