Synthesis and antiaggregatory activity of antiflammin related peptides

Farmaco. 1991 Nov;46(11):1265-72.

Abstract

The peptide H-Lys-Val-Leu-Asp-OH (KVLD), derived from antiflammins, and its analog H-Lys-Val-Asp-Leu-OH (KVDL) were prepared by solution synthesis. KVLD does not inhibit platelet aggregation in contrast to the results recently published.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Chemical Phenomena
  • Chemistry, Physical
  • Fibrinogen / metabolism
  • Humans
  • In Vitro Techniques
  • Molecular Sequence Data
  • Oligopeptides / chemical synthesis*
  • Oligopeptides / pharmacology
  • Platelet Aggregation Inhibitors / chemical synthesis*
  • Platelet Aggregation Inhibitors / pharmacology

Substances

  • Oligopeptides
  • Platelet Aggregation Inhibitors
  • lysyl-valyl-leucyl-aspartic acid
  • lysyl-valyl-aspartyl-leucine
  • Fibrinogen