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Interference of enantiomers of lofexidine with alpha-adrenoceptors.
Wilffert B, Mathy MJ, Batink HD, de Jonge A, Thoolen MJ, Prop G, Graf E, Timmermans PB, van Zwieten PA. Wilffert B, et al. Arch Int Pharmacodyn Ther. 1985 Jan;273(1):18-32. Arch Int Pharmacodyn Ther. 1985. PMID: 2988468
Some alpha-adrenoceptor-mediated cardiovascular activities and alpha-adrenoceptor binding affinities for (+)- and (-)-lofexidine (Dexlofexidine and Levlofexidine) have been studied in comparison with racemic lofexidine. ...
Some alpha-adrenoceptor-mediated cardiovascular activities and alpha-adrenoceptor binding affinities for (+)- and (-)-lofexidine (Dexlofexid …
Two stereoisomeric imidazoline derivatives: synthesis and optical and alpha 2-adrenoceptor activities.
Biedermann J, León-Lomelí A, Borbe HO, Prop G. Biedermann J, et al. J Med Chem. 1986 Jul;29(7):1183-8. doi: 10.1021/jm00157a011. J Med Chem. 1986. PMID: 2879913
Two eight-step pathways for synthesizing the stereoisomeric compounds (-)-2-[1-(2,6-dichlorophenoxy)ethyl]-2-imidazoline hydrochloride ("levlofexidine" hydrochloride; (-)-lofexidine hydrochloride) and (+)-2-[1-(2,6-dichlorophenoxy)ethyl]-2-imidazoline hydrochloride ("dexlo …
Two eight-step pathways for synthesizing the stereoisomeric compounds (-)-2-[1-(2,6-dichlorophenoxy)ethyl]-2-imidazoline hydrochloride (" …