Search Page
Save citations to file
Email citations
Send citations to clipboard
Add to Collections
Add to My Bibliography
Create a file for external citation management software
Your saved search
Your RSS Feed
Filters
Results by year
Table representation of search results timeline featuring number of search results per year.
Year | Number of Results |
---|---|
2011 | 1 |
2012 | 2 |
2013 | 2 |
2014 | 2 |
2024 | 0 |
Search Results
5 results
Results by year
Filters applied: . Clear all
Quoted phrase not found in phrase index: "Odelepran"
Page 1
Opioid modulators for alcohol dependence.
Expert Opin Investig Drugs. 2011 Aug;20(8):1073-86. doi: 10.1517/13543784.2011.592139. Epub 2011 Jun 9.
Expert Opin Investig Drugs. 2011.
PMID: 21651459
Review.
Naltrexone- and to a lesser extent nalmefene- is an agent that modulates opioidergic transmission in the CNS and it shows a limited but well-studied efficacy in treating alcohol dependence. Several agents (LY2196044, ALKS-29, ALKS-33) that are currently undergoing Phase II …
Naltrexone- and to a lesser extent nalmefene- is an agent that modulates opioidergic transmission in the CNS and it shows a limited but well …
Investigation of clinical pharmacokinetic variability of an opioid antagonist through physiologically based absorption modeling.
Ding X, He M, Kulkarni R, Patel N, Zhang X.
Ding X, et al.
J Pharm Sci. 2013 Aug;102(8):2859-74. doi: 10.1002/jps.23629. Epub 2013 Jun 11.
J Pharm Sci. 2013.
PMID: 23761048
Clinical Trial.
Here we present an integrated approach of physiologically based absorption modeling to investigate the root cause of unexpectedly high PK variability of a Phase I clinical trial drug. LY2196044 exhibited high intersubject variability in the absorption phase of plasma conce …
Here we present an integrated approach of physiologically based absorption modeling to investigate the root cause of unexpectedly high PK va …
Item in Clipboard
A phase 2, placebo-controlled study of the opioid receptor antagonist LY2196044 for the treatment of alcohol dependence.
Wong CJ, Witcher J, Mallinckrodt C, Dean RA, Anton RF, Chen Y, Fijal BA, Ouyang H, Dharia S, Sundseth SS, Schuh KJ, Kinon BJ.
Wong CJ, et al.
Alcohol Clin Exp Res. 2014 Feb;38(2):511-20. doi: 10.1111/acer.12257. Epub 2013 Sep 6.
Alcohol Clin Exp Res. 2014.
PMID: 24010675
Clinical Trial.
RESULTS: The treatment difference in change from baseline in % HDD between LY2196044 and placebo was not statistically significant (-43.02 vs. -38.72%, respectively; p = 0.12). ...The safety profile for LY2196044 appeared similar to that of other opioid antagonists. …
RESULTS: The treatment difference in change from baseline in % HDD between LY2196044 and placebo was not statistically significant (- …
Item in Clipboard
Baclofen effects on alcohol seeking, self-administration and extinction of seeking responses in a within-session design in baboons.
Duke AN, Kaminski BJ, Weerts EM.
Duke AN, et al.
Addict Biol. 2014 Jan;19(1):16-26. doi: 10.1111/j.1369-1600.2012.00448.x. Epub 2012 Mar 28.
Addict Biol. 2014.
PMID: 22458648
Free PMC article.
Item in Clipboard
Effects of naltrexone on alcohol drinking patterns and extinction of alcohol seeking in baboons.
Kaminski BJ, Duke AN, Weerts EM.
Kaminski BJ, et al.
Psychopharmacology (Berl). 2012 Sep;223(1):55-66. doi: 10.1007/s00213-012-2688-y. Epub 2012 Mar 27.
Psychopharmacology (Berl). 2012.
PMID: 22451093
Free PMC article.
Item in Clipboard
Cite
Cite