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Did you mean L 654969 OR tserivastatin OR 121009-77-6 [rn] (191 results)?
Impact of OATP transporters on pharmacokinetics.
Kalliokoski A, Niemi M. Kalliokoski A, et al. Br J Pharmacol. 2009 Oct;158(3):693-705. doi: 10.1111/j.1476-5381.2009.00430.x. Epub 2009 Sep 25. Br J Pharmacol. 2009. PMID: 19785645 Free PMC article. Review.
For example, a single nucleotide polymorphism (c.521T > C, p.Val174Ala) in the SLCO1B1 gene encoding OATP1B1 decreases the ability of OATP1B1 to transport active simvastatin acid from portal circulation into the liver, resulting in markedly increased plasma conce …
For example, a single nucleotide polymorphism (c.521T > C, p.Val174Ala) in the SLCO1B1 gene encoding OATP1B1 decreases the ability of OAT …
Effect of eight common Brazilian drugs on Lemna minor and Salvinia auriculata growth.
Ikebe Otomo J, Araujo de Jesus T, Gomes Coelho LH, Rebelo Monteiro L, Hunter C, Helwig K, Roberts J, Pahl O. Ikebe Otomo J, et al. Environ Sci Pollut Res Int. 2021 Aug;28(32):43747-43762. doi: 10.1007/s11356-021-13795-9. Epub 2021 Apr 10. Environ Sci Pollut Res Int. 2021. PMID: 33837946
The growth of two species of macrophytes (Lemna minor and Salvinia auriculata) under the effect of a mixture of amoxicillin, caffeine, carbamazepine, dipyrone, ibuprofen, losartan, omeprazole, and tenivastatin was investigated by bioassay. Three concentration levels were u …
The growth of two species of macrophytes (Lemna minor and Salvinia auriculata) under the effect of a mixture of amoxicillin, caffeine, carba …
Genomewide Association Study of Simvastatin Pharmacokinetics.
Mykkänen AJH, Taskinen S, Neuvonen M, Paile-Hyvärinen M, Tarkiainen EK, Lilius T, Tapaninen T, Backman JT, Tornio A, Niemi M. Mykkänen AJH, et al. Clin Pharmacol Ther. 2022 Sep;112(3):676-686. doi: 10.1002/cpt.2674. Epub 2022 Jun 24. Clin Pharmacol Ther. 2022. PMID: 35652242 Free PMC article.
In a microarray-based genomewide association study with the prospective data, the SLCO1B1 c.521T>C (p.Val174Ala, rs4149056) single nucleotide variation showed the strongest, genomewide significant association with the area under the plasma simvastatin acid concen …
In a microarray-based genomewide association study with the prospective data, the SLCO1B1 c.521T>C (p.Val174Ala, rs4149056) single nucleo …
Quantification of serum levels in mice of seven drugs (and six metabolites) commonly taken by older people with polypharmacy.
Mach J, Wang X, Hilmer SN. Mach J, et al. Fundam Clin Pharmacol. 2021 Apr;35(2):410-422. doi: 10.1111/fcp.12602. Epub 2020 Oct 14. Fundam Clin Pharmacol. 2021. PMID: 32813878
Serum samples from mice (n = 5-6/group) treated with chronic oral doses of three polypharmacy regimens and five monotherapies were screened for drug and metabolite levels (metoprolol, alpha-hydroxymetoprolol, O-desmethylmetoprolol, omeprazole, 5-hydroxyomeprazole, omeprazole sulp …
Serum samples from mice (n = 5-6/group) treated with chronic oral doses of three polypharmacy regimens and five monotherapies were screened …
Role of monocarboxylate transporters in drug delivery to the brain.
Vijay N, Morris ME. Vijay N, et al. Curr Pharm Des. 2014;20(10):1487-98. doi: 10.2174/13816128113199990462. Curr Pharm Des. 2014. PMID: 23789956 Free PMC article. Review.
Apart from endogenous short chain monocarboxylates, they also mediate the transport of exogenous drugs such as salicylic acid, valproic acid, and simvastatin acid. The influence of MCTs on drug pharmacokinetics has been extensively studied for gamma-hydroxybutyrate …
Apart from endogenous short chain monocarboxylates, they also mediate the transport of exogenous drugs such as salicylic acid, valproic acid …
Engineering Saccharomyces cerevisiae for production of simvastatin.
Bond CM, Tang Y. Bond CM, et al. Metab Eng. 2019 Jan;51:1-8. doi: 10.1016/j.ymben.2018.09.005. Epub 2018 Sep 10. Metab Eng. 2019. PMID: 30213650 Free PMC article.
Simvastatin is a semisynthetic cholesterol-lowering medication and one of the top-selling statins in the world. Currently, industrial production of simvastatin acid (SVA) is a multistep process starting from the natural product lovastatin. ...
Simvastatin is a semisynthetic cholesterol-lowering medication and one of the top-selling statins in the world. Currently, industrial produc …
Clinical pharmacokinetics and practical applications of simvastatin.
Mauro VF. Mauro VF. Clin Pharmacokinet. 1993 Mar;24(3):195-202. doi: 10.2165/00003088-199324030-00002. Clin Pharmacokinet. 1993. PMID: 8343198 Review.
Like lovastatin, it is an inactive hydrophobic lactone prodrug which is metabolised in vivo to several more polar, pharmacologically active compounds, most notably the corresponding hydroxy acid form, simvastatin acid. HPLC techniques have been developed to assay si …
Like lovastatin, it is an inactive hydrophobic lactone prodrug which is metabolised in vivo to several more polar, pharmacologically active …
Comparative Hepatic and Intestinal Efflux Transport of Statins.
Deng F, Tuomi SK, Neuvonen M, Hirvensalo P, Kulju S, Wenzel C, Oswald S, Filppula AM, Niemi M. Deng F, et al. Drug Metab Dispos. 2021 Sep;49(9):750-759. doi: 10.1124/dmd.121.000430. Epub 2021 Jun 23. Drug Metab Dispos. 2021. PMID: 34162690
SIGNIFICANCE STATEMENT: This study characterized and compared the transport of atorvastatin, fluvastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin acid and four atorvastatin metabolites by six ABC transporters (BCRP, MRP2, MRP3, MRP4, MRP8, P-gp). .. …
SIGNIFICANCE STATEMENT: This study characterized and compared the transport of atorvastatin, fluvastatin, pitavastatin, pravastatin, rosuvas …
Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin.
Neuvonen PJ, Backman JT, Niemi M. Neuvonen PJ, et al. Clin Pharmacokinet. 2008;47(7):463-74. doi: 10.2165/00003088-200847070-00003. Clin Pharmacokinet. 2008. PMID: 18563955 Review.
The c.521T>C (p.Val174Ala) genetic polymorphism of SLCO1B1 (encoding OATP1B1) considerably increases the plasma concentrations of simvastatin acid and moderately increases those of pravastatin but seems to have no significant effect on fluvastatin. ...Potent indu …
The c.521T>C (p.Val174Ala) genetic polymorphism of SLCO1B1 (encoding OATP1B1) considerably increases the plasma concentrations of simv
Disease-Drug Interaction of Sarilumab and Simvastatin in Patients with Rheumatoid Arthritis.
Lee EB, Daskalakis N, Xu C, Paccaly A, Miller B, Fleischmann R, Bodrug I, Kivitz A. Lee EB, et al. Clin Pharmacokinet. 2017 Jun;56(6):607-615. doi: 10.1007/s40262-016-0462-8. Clin Pharmacokinet. 2017. PMID: 27722854 Free PMC article. Clinical Trial.
The pharmacokinetic parameters of simvastatin and its primary metabolite, beta-hydroxy-simvastatin acid, were calculated using noncompartmental analysis. RESULTS: Compared with simvastatin alone, single-dose simvastatin administration 7 days after single-dose sarilu …
The pharmacokinetic parameters of simvastatin and its primary metabolite, beta-hydroxy-simvastatin acid, were calculated using …
192 results