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Page 1
Oriental traditional herbal Medicine--Puerariae Flos: A systematic review.
Chen C, Li X, Kano Y, Yuan D, Qu J. Chen C, et al. J Ethnopharmacol. 2023 Apr 24;306:116089. doi: 10.1016/j.jep.2022.116089. Epub 2023 Jan 5. J Ethnopharmacol. 2023. PMID: 36621660 Review.
CONCLUSIONS: Comprehensive analysis showed that pharmacological activity of most purified compounds from PF had not been reported. Kakkalide, tectoridin and their deglycosylated metabolites (irisolidone and tectorigenin) has been focused on excessively due to their higher …
CONCLUSIONS: Comprehensive analysis showed that pharmacological activity of most purified compounds from PF had not been reported. Kakkal …
Irisolidone attenuates ethanol-induced gastric injury in mice by inhibiting the infiltration of neutrophils.
Kang GD, Lee SY, Jang SE, Han MJ, Kim DH. Kang GD, et al. Mol Nutr Food Res. 2017 Feb;61(2). doi: 10.1002/mnfr.201600517. Epub 2016 Oct 5. Mol Nutr Food Res. 2017. PMID: 27546737
SCOPE: This study was designed to determine whether irisolidone and its glycoside kakkalide, which are the major constituents of the flower of Pueraria lobata (Kudzu) can attenuate ethanol-induced gastritic injury in mice. METHODS AND RESULTS: Irisolidone and kakkalide …
SCOPE: This study was designed to determine whether irisolidone and its glycoside kakkalide, which are the major constituents of the …
Hepatoprotective effects of irisolidone on tert-butyl hyperoxide-induced liver injury.
Lee HU, Bae EA, Kim DH. Lee HU, et al. Biol Pharm Bull. 2005 Mar;28(3):531-3. doi: 10.1248/bpb.28.531. Biol Pharm Bull. 2005. PMID: 15744084 Free article.
The inhibitory effect of kakkalide is much more potent than that of silybin, a hepatoprotective agent. ...Based on these findings, irisolidone can be hepatoprotective and kakkalide may be a prodrug transformed to irisolidone....
The inhibitory effect of kakkalide is much more potent than that of silybin, a hepatoprotective agent. ...Based on these findings, ir …
Biological Potential of Kakkalide in medicine for the Treatment of Human disorders: An Overview of Pharmacological aspects.
Patel DK, Patel K. Patel DK, et al. Curr Drug Res Rev. 2023 Aug 24. doi: 10.2174/2589977515666230824152740. Online ahead of print. Curr Drug Res Rev. 2023. PMID: 37622718
Moreover, Kakkalide has a wide range of bioactivities in medicine. METHODS: Biological potential of kakkalide was investigated in the present work through scientific data analysis of different scientific research work on kakkalide in order to know its therape …
Moreover, Kakkalide has a wide range of bioactivities in medicine. METHODS: Biological potential of kakkalide was investigated …
Kakkalide and irisolidone alleviate 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice by inhibiting lipopolysaccharide binding to toll-like receptor-4 and proteobacteria population.
Jang HM, Park KT, Noh HD, Lee SH, Kim DH. Jang HM, et al. Int Immunopharmacol. 2019 Aug;73:246-253. doi: 10.1016/j.intimp.2019.05.008. Epub 2019 May 18. Int Immunopharmacol. 2019. PMID: 31112869
Kakkalide and its metabolite irisolidone inhibited lipopolysaccharide (LPS)-stimulated NF-kappaB activation and TNF-alpha expression in macrophages. ...Overall, the anti-colitic effects of irisolidone were superior to those of kakkalide. Kakkalide and its met …
Kakkalide and its metabolite irisolidone inhibited lipopolysaccharide (LPS)-stimulated NF-kappaB activation and TNF-alpha expression …
Kakkalide ameliorates endothelial insulin resistance by suppressing reactive oxygen species-associated inflammation.
Zhang D, Gao X, Wang Q, Qin M, Liu K, Huang F, Liu B. Zhang D, et al. J Diabetes. 2013 Mar;5(1):13-24. doi: 10.1111/1753-0407.12017. J Diabetes. 2013. PMID: 23190749
BACKGROUND: Kakkalide is the predominant isoflavone derived from the flowers of Pueraria lobata (Willd.) ...CONCLUSIONS: Kakkalide inhibited ROS-associated inflammation and ameliorated insulin-resistant endothelial dysfunction by beneficial effects on IRS-1 function …
BACKGROUND: Kakkalide is the predominant isoflavone derived from the flowers of Pueraria lobata (Willd.) ...CONCLUSIONS: Kakkalide …
Estrogenic effect of main components kakkalide and tectoridin of Puerariae Flos and their metabolites.
Shin JE, Bae EA, Lee YC, Ma JY, Kim DH. Shin JE, et al. Biol Pharm Bull. 2006 Jun;29(6):1202-6. doi: 10.1248/bpb.29.1202. Biol Pharm Bull. 2006. PMID: 16755017 Free article.
All human fecal specimens metabolized kakkalide and tectoridin. All isolated kakkalide-hydrolyzing intestinal bacteria also hydrolyzed kakkalide and tectoridin to irisolidone and tectorigenin, respectively. When the estrogenic effects of kakkalide and …
All human fecal specimens metabolized kakkalide and tectoridin. All isolated kakkalide-hydrolyzing intestinal bacteria also hy …
Kakkalide and its metabolite irisolidone ameliorate carrageenan-induced inflammation in mice by inhibiting NF-kappaB pathway.
Min SW, Park YJ, Kim DH. Min SW, et al. Inflammation. 2011 Oct;34(5):344-51. doi: 10.1007/s10753-010-9240-1. Inflammation. 2011. PMID: 20686830
The anti-inflammatory activities of kakkalide, a major constituent of the flower of Pueraria thunbergiana, and irisolidone, a metabolite of kakkalide produced by intestinal microflora, against carrageenan-induced inflammation in air pouches on the backs of mice and …
The anti-inflammatory activities of kakkalide, a major constituent of the flower of Pueraria thunbergiana, and irisolidone, a metabol …
Metabolism and excretion of kakkalide and its metabolites in rat urine, bile, and feces as determined by HPLC/UV and LC/MS/MS.
Wang H, Bai X, Sun J, Kano Y, Makino T, Yuan D. Wang H, et al. Planta Med. 2013 Nov;79(16):1552-7. doi: 10.1055/s-0033-1350832. Epub 2013 Oct 9. Planta Med. 2013. PMID: 24108437
Over a 72-h period, 13.2 2.8 % of the kakkalide was excreted as seven metabolites in urine. Over the same time period, irisolidone-7-O-glucuronide excretion in bile accounted for 3.8 1.1 % of the dose, while kakkalide and irisolidone excretion in feces accounted for …
Over a 72-h period, 13.2 2.8 % of the kakkalide was excreted as seven metabolites in urine. Over the same time period, irisolidone-7- …
Isolation and identification of urinary metabolites of kakkalide in rats.
Bai X, Xie Y, Liu J, Qu J, Kano Y, Yuan D. Bai X, et al. Drug Metab Dispos. 2010 Feb;38(2):281-6. doi: 10.1124/dmd.109.028555. Epub 2009 Nov 12. Drug Metab Dispos. 2010. PMID: 19910516
Kakkalide is a major isoflavonoid from the flowers of Pueraria lobata (Willd.) Ohwi, possessing the protective effect against ethanol-induced intoxication and hepatic injury. The metabolism of kakkalide was investigated in rats. Thirteen metabolites were isolated by …
Kakkalide is a major isoflavonoid from the flowers of Pueraria lobata (Willd.) Ohwi, possessing the protective effect against ethanol …
30 results