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Page 1
Divergent receptor proteins confer responses to different karrikins in two ephemeral weeds.
Sun YK, Yao J, Scaffidi A, Melville KT, Davies SF, Bond CS, Smith SM, Flematti GR, Waters MT. Sun YK, et al. Nat Commun. 2020 Mar 9;11(1):1264. doi: 10.1038/s41467-020-14991-w. Nat Commun. 2020. PMID: 32152287 Free PMC article.
In contrast, the closely-related yet non-fire-associated ephemeral Arabidopsis thaliana is unusual because it responds preferentially to KAR(2). The alpha/beta-hydrolase KARRIKIN INSENSITIVE 2 (KAI2) is the putative karrikin receptor identified in Arabidopsis. Here …
In contrast, the closely-related yet non-fire-associated ephemeral Arabidopsis thaliana is unusual because it responds preferentially to …
Karrikins control seedling photomorphogenesis and anthocyanin biosynthesis through a HY5-BBX transcriptional module.
Bursch K, Niemann ET, Nelson DC, Johansson H. Bursch K, et al. Plant J. 2021 Sep;107(5):1346-1362. doi: 10.1111/tpj.15383. Epub 2021 Jul 19. Plant J. 2021. PMID: 34160854 Free article.
The bbx20 bbx21 mutant is largely insensitive to treatment with KAR(2) , similar to a hy5 mutant, with regards to inhibition of hypocotyl elongation and anthocyanin accumulation. ...However, the promotion of hypocotyl elongation by SMAX1 and SMXL2 is, in contrast to …
The bbx20 bbx21 mutant is largely insensitive to treatment with KAR(2) , similar to a hy5 mutant, with regards to inhibition o …
MAX2-independent transcriptional responses to rac-GR24 in Lotus japonicus roots.
Carbonnel S, Torabi S, Gutjahr C. Carbonnel S, et al. Plant Signal Behav. 2021 Jan 2;16(1):1840852. doi: 10.1080/15592324.2020.1840852. Epub 2020 Oct 30. Plant Signal Behav. 2021. PMID: 33126824 Free PMC article.
Current research on SL and KAR signaling uses the synthetic molecules rac-GR24, KAR(1) and KAR(2) for pharmacological treatments. In a previous microarray analysis, we observed transcriptional activation in response to rac-GR24 in Lotus japonicus seedling roots. ...
Current research on SL and KAR signaling uses the synthetic molecules rac-GR24, KAR(1) and KAR(2) for pharmacological treatmen …
A stable isotope dilution method for a highly accurate analysis of karrikins.
Hrdlička J, Gucký T, van Staden J, Novák O, Doležal K. Hrdlička J, et al. Plant Methods. 2021 Apr 1;17(1):37. doi: 10.1186/s13007-021-00738-1. Plant Methods. 2021. PMID: 33794941 Free PMC article.
RESULTS: We present a sensitive method for the determination of two highly biologically active karrikins (KAR(1) and KAR(2)) in minute amounts of plant material (< 20 mg fresh weight). ...The applicability of this analytical approach was confirmed by the successf …
RESULTS: We present a sensitive method for the determination of two highly biologically active karrikins (KAR(1) and KAR(2)) i …
New anti-mitotic drugs with distinct anti-calmodulin activity.
Orosz F, Horváth I, Ovádi J. Orosz F, et al. Mini Rev Med Chem. 2006 Oct;6(10):1145-57. doi: 10.2174/138955706778560094. Mini Rev Med Chem. 2006. PMID: 17073715 Review.
This new drug family appears to be less potent than vinblastine in vitro systems, but it shows high antitumor efficacy with considerably higher doses being well tolerated in the animal tumor models. 3D data of calmodulin complexed with KAR-2 explain the specificity …
This new drug family appears to be less potent than vinblastine in vitro systems, but it shows high antitumor efficacy with considerably hig …
The interaction of a new anti-tumour drug, KAR-2 with calmodulin.
Orosz F, Vértessy BG, Salerno C, Crifo C, Capuozzo E, Ovádi J. Orosz F, et al. Br J Pharmacol. 1997 Jul;121(5):955-62. doi: 10.1038/sj.bjp.0701190. Br J Pharmacol. 1997. PMID: 9222553 Free PMC article.
KAR-2 was able to interact with apo-calmodulin as well; in the absence of Ca2+ the binding was of cooperative nature. 4. ...Comparison of the data obtained with KAR-2 and bis-indols used in chemotherapy suggests that the lack of anti-calmodulin potency …
KAR-2 was able to interact with apo-calmodulin as well; in the absence of Ca2+ the binding was of cooperative nature. 4. ...Co …
Effects of the semisynthetic bis-indole derivative KAR-2 on store-operated calcium entry in human neutrophils.
Salerno C, Capuozzo E. Salerno C, et al. Arch Biochem Biophys. 2013 Sep 1;537(1):133-7. doi: 10.1016/j.abb.2013.07.011. Epub 2013 Jul 19. Arch Biochem Biophys. 2013. PMID: 23876240
We found that KAR-2 induces Ca(2+) release from intracellular stores, whereby the stores are depleted. In addition KAR-2 reduces store-operated entry of extracellular Ca(2+) induced by agonists such as thapsigargin or ATP. ...
We found that KAR-2 induces Ca(2+) release from intracellular stores, whereby the stores are depleted. In addition KAR- …
KARRIKIN INSENSITIVE2 regulates leaf development, root system architecture and arbuscular-mycorrhizal symbiosis in Brachypodium distachyon.
Meng Y, Varshney K, Incze N, Badics E, Kamran M, Davies SF, Oppermann LMF, Magne K, Dalmais M, Bendahmane A, Sibout R, Vogel J, Laudencia-Chingcuanco D, Bond CS, Soós V, Gutjahr C, Waters MT. Meng Y, et al. Plant J. 2022 Mar;109(6):1559-1574. doi: 10.1111/tpj.15651. Epub 2022 Feb 23. Plant J. 2022. PMID: 34953105 Free article.
Bdkai2 shows increased numbers of lateral roots and reduced root hair growth, and fails to support normal root colonisation by arbuscular-mycorrhizal (AM) fungi. The karrikins KAR(1) and KAR(2) , and the strigolactone (SL) analogue rac-GR24, each elicit overlapping …
Bdkai2 shows increased numbers of lateral roots and reduced root hair growth, and fails to support normal root colonisation by arbuscular-my …
Unique pharmacology of KAR-2, a potential anti-cancer agent: absorption modelling and selective mitotic spindle targeting.
Gonzalez-Alvarez I, Gonzalez-Alvarez M, Oltra-Noguera D, Merino V, Tõkési N, Ovádi J, Bermejo M. Gonzalez-Alvarez I, et al. Eur J Pharm Sci. 2009 Jan 31;36(1):11-9. doi: 10.1016/j.ejps.2008.10.020. Epub 2008 Nov 5. Eur J Pharm Sci. 2009. PMID: 19028571
We showed that KAR-2 impeded specifically the cell division. On the other hand, we elucidated the transport mechanisms of KAR-2 as compared to vinblastine, applying pharmacokinetic modelling based upon the combination of the data obtained from in situ …
We showed that KAR-2 impeded specifically the cell division. On the other hand, we elucidated the transport mechanisms of K …
24 results