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Page 1
Effect of the hypoxic cell sensitizer isometronidazole on local control of two human squamous cell carcinomas after fractionated irradiation.
Schreiber A, Krause M, Zips D, Dörfler A, Richter K, Vettermann S, Petersen C, Beuthien-Baumann B, Thümmler D, Baumann M. Schreiber A, et al. Strahlenther Onkol. 2004 Jun;180(6):375-82. doi: 10.1007/s00066-004-1206-5. Strahlenther Onkol. 2004. PMID: 15175873
The objective of the present study was to test the efficacy of the hypoxic cell sensitizer isometronidazole (ISO) during fractionated irradiation in two different human squamous cell carcinomas. ...
The objective of the present study was to test the efficacy of the hypoxic cell sensitizer isometronidazole (ISO) during fractionated …
[The pharmacokinetics of 2-methyl-4-nitroimidazole-1-ethanol (isometronidazole) in man].
Siegmund W, Zschiesche M, Franke G, Peters R, Brachmann O, Scherber A. Siegmund W, et al. Pharmazie. 1988 Aug;43(8):546-8. Pharmazie. 1988. PMID: 3237745 German.
2 and 4 g isometronidazole, respectively, were administered to two groups of 6 healthy male volunteers (21-29 years, 62-93 kg). The unchanged compound and its nitro group containing metabolites were measured by HPLC and polarography. Isometronidazole was absorbed ra …
2 and 4 g isometronidazole, respectively, were administered to two groups of 6 healthy male volunteers (21-29 years, 62-93 kg). The u …
[Radiosensitizing and toxic action of metronidazole and isometronidazole (1-(2-hydroxyethyl)-2-methyl-4-nitroimidazole) on the cells of Ehrlich ascites cancer and hemoblastosis La in vitro].
Proskuriakov SIa, Smoryzanova OA, Dedenkov AN, Riabchenko NI. Proskuriakov SIa, et al. Radiobiologiia. 1986 Nov-Dec;26(6):766-70. Radiobiologiia. 1986. PMID: 3809411 Russian.
A study was made of Ehrlich ascites tumor growth and life span of mice bearing hemoblastosis La after inoculation of tumor cells subjected, in anaerobic conditions, to the effect of gamma-radiation and/or metronidazole and isometronidazole. It was shown that the cytotoxic …
A study was made of Ehrlich ascites tumor growth and life span of mice bearing hemoblastosis La after inoculation of tumor cells subjected, …
Pharmacokinetics of isometronidazole. Basic model and estimation of the kinetic parameters from experimental data.
Hentschel M, Schmidt W. Hentschel M, et al. Pharmazie. 1992 Mar;47(3):221-4. Pharmazie. 1992. PMID: 1615029
We have studied the pharmacokinetics of the hypoxic cell sensitizer isometronidazole in man and mouse and analyzed the data on the basis of an open two-compartment model after extravasal application. ...
We have studied the pharmacokinetics of the hypoxic cell sensitizer isometronidazole in man and mouse and analyzed the data on the ba …
[Radiosensitizing and toxic effect of metronidazole and its ortho-isomer 1-(2-hydroxyethyl)-2-methyl-4-nitroimidazole on Escherichia coli B/r cells].
Riabchenko NI, Petrova KM, Proskuriakov SIa. Riabchenko NI, et al. Radiobiologiia. 1985 Nov-Dec;25(6):744-7. Radiobiologiia. 1985. PMID: 3909211 Russian.
A study was made of the effect of metronidazole and isometronidazole on the survival rate of irradiated and nonirradiated E. coli B/r cells. These substances had similar radiosensitizing activity with regard to anoxic cells and did not sensitize cells irradiated in the air …
A study was made of the effect of metronidazole and isometronidazole on the survival rate of irradiated and nonirradiated E. coli B/r …
[The immediate results of the use of isometronidazole in the combination therapy of patients with lung cancer].
Zharkov VV, Merkle KKh, Gentshel M, Furmanchuk AV, Kurchin VP, Demidchik IuE, Moiseev PI. Zharkov VV, et al. Med Radiol (Mosk). 1991;36(7):18-20. Med Radiol (Mosk). 1991. PMID: 1881282 Russian.
The paper is devoted to assessment of isometronidazole tolerance, used as a radiosensitizer for preoperative irradiation of lung cancer patients, and to characterization of morphological postradiation changes in tissues of carcinomas removed at operation. Isometronidazo …
The paper is devoted to assessment of isometronidazole tolerance, used as a radiosensitizer for preoperative irradiation of lung canc …
12 results