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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 3
1982 2
1985 1
1986 1
2002 1
2006 1
2007 2
2010 1
2011 1
2012 1
2013 1
2014 2
2016 1
2017 2
2019 2
2020 4
2021 1
2023 1
2024 1

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26 results

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Page 1
Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase.
Zhang D, Xu G, Zhao J, Wang Y, Wu X, He X, Li W, Zhang S, Yang S, Ma C, Jiang Y, Ding Q. Zhang D, et al. Eur J Med Chem. 2021 Dec 5;225:113724. doi: 10.1016/j.ejmech.2021.113724. Epub 2021 Jul 29. Eur J Med Chem. 2021. PMID: 34391034
Accordingly, here, based on Zanubrutinib, we designed and synthesized a new range of imidazopyrazole-3-carboxamide derivatives as novel BTK inhibitors that retained the amide group for improved selectivity. ...
Accordingly, here, based on Zanubrutinib, we designed and synthesized a new range of imidazopyrazole-3-carboxamide derivatives as nov …
Discovery of New Antiproliferative Imidazopyrazole Acylhydrazones Able To Interact with Microtubule Systems.
Brullo C, Rapetti F, Alfei S, Maric I, Rizzelli F, Mapelli M, Rosano C, Viale M, Bruno O. Brullo C, et al. ChemMedChem. 2020 Jun 4;15(11):961-969. doi: 10.1002/cmdc.202000122. Epub 2020 Apr 27. ChemMedChem. 2020. PMID: 32233110
To expand our investigation in the anticancer field, we report here a new series of compounds in which our previous pyrazole and imidazopyrazole scaffolds are linked to a differently decorated phenyl ring through an acylhydrazone linker. ...Two compounds, in particular 4-b …
To expand our investigation in the anticancer field, we report here a new series of compounds in which our previous pyrazole and imidazop
New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets.
Brullo C, Massa M, Rapetti F, Alfei S, Bertolotto MB, Montecucco F, Signorello MG, Bruno O. Brullo C, et al. Molecules. 2020 Feb 18;25(4):899. doi: 10.3390/molecules25040899. Molecules. 2020. PMID: 32085423 Free PMC article.
Several anti-inflammatory agents based on pyrazole and imidazopyrazole scaffolds and a large library of substituted catechol PDE4D inhibitors were reported by us in the recent past. ...Structure-activity relationship (SAR) analyses evidenced that both heterocyclic scaffold …
Several anti-inflammatory agents based on pyrazole and imidazopyrazole scaffolds and a large library of substituted catechol PDE4D in …
Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis.
Meta E, Brullo C, Sidibe A, Imhof BA, Bruno O. Meta E, et al. Eur J Med Chem. 2017 Jun 16;133:24-35. doi: 10.1016/j.ejmech.2017.03.066. Epub 2017 Mar 27. Eur J Med Chem. 2017. PMID: 28371678
SAR consideration showed that specific substituents and their position in pyrazole nucleus, as well as the type of substituent on the phenylurea moiety play a pivotal role in determining increase or decrease of kinases phosphorylation. On the other hand the loss of flexibility in …
SAR consideration showed that specific substituents and their position in pyrazole nucleus, as well as the type of substituent on the phenyl …
Ultrasound-assisted one-pot four-component synthesis of novel 2-amino-3-cyanopyridine derivatives bearing 5-imidazopyrazole scaffold and their biological broadcast.
Kalaria PN, Satasia SP, Avalani JR, Raval DK. Kalaria PN, et al. Eur J Med Chem. 2014 Aug 18;83:655-64. doi: 10.1016/j.ejmech.2014.06.071. Epub 2014 Jun 30. Eur J Med Chem. 2014. PMID: 25010936
An alternative and environmentally caring way for the synthesis of novel 2-amino-3-cyanopyridine derivatives bearing 5-imidazopyrazole nucleus is reported by one-pot four-component cyclocondensation reaction of substituted 5-(1H-imidazol/4-methyl-1-yl)-3-methyl-1-phenyl-1H …
An alternative and environmentally caring way for the synthesis of novel 2-amino-3-cyanopyridine derivatives bearing 5-imidazopyrazole
Redox-neutral zinc-catalyzed cascade [1,4]-H shift/annulation of diaziridines with donor-acceptor aziridines.
Samantaray S, Maharana PK, Kar S, Saha S, Punniyamurthy T. Samantaray S, et al. Chem Commun (Camb). 2024 Mar 21;60(25):3441-3444. doi: 10.1039/d4cc00226a. Chem Commun (Camb). 2024. PMID: 38445334
The coupling of diaziridines with donor-acceptor aziridines (DAAs) has been achieved using Zn-catalysis to furnish imidazopyrazole-4,4-dicarboxylates via [1,4]-hydride shift. The use of Zn-catalysis, [1,4]-hydride shift, natural product modification and a late-stage molecu …
The coupling of diaziridines with donor-acceptor aziridines (DAAs) has been achieved using Zn-catalysis to furnish imidazopyrazole-4, …
Studies on the clinical pharmacokinetics of imidazopyrazole.
Allen LM, Feely M, Denefrio J. Allen LM, et al. J Clin Pharmacol. 1980 May-Jun;20(5-6 Pt 1):341-6. doi: 10.1177/009127008002000506. J Clin Pharmacol. 1980. PMID: 7400371
Plasma decay kinetics were analyzed for seven patients (400-5700 mg) during a Phase I clinical trial of imidazopyrazole. A two-compartment open pharmacokinetic model was able to account for the data. .../m2, and volume of distribution at steady state was 40.2 l./m2. Renal …
Plasma decay kinetics were analyzed for seven patients (400-5700 mg) during a Phase I clinical trial of imidazopyrazole. A two-compar …
26 results