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Page 1
Highly mutable sites for ICR-170-induced frameshift mutations are associated with potential DNA hairpin structures: studies with SUP4 and other Saccharomyces cerevisiae genes.
Hampsey DM, Koski RA, Sherman F. Hampsey DM, et al. Mol Cell Biol. 1986 Dec;6(12):4425-32. doi: 10.1128/mcb.6.12.4425-4432.1986. Mol Cell Biol. 1986. PMID: 2432400 Free PMC article.
The majority of the mutations induced by ICR-170 in both the CYC1 gene (J. F. Ernst et al. Genetics 111:233-241, 1985) and the HIS4 gene (L. ...Based on these results and recent information regarding novel DNA structural conformations, we present a mechanism for …
The majority of the mutations induced by ICR-170 in both the CYC1 gene (J. F. Ernst et al. Genetics 111:233-241, 1985) and the …
Selective deactivation of ICR mutagens as related to their distinctive pulmonary carcinogenicity.
De Flora S, Morelli A, Zanacchi P, Bennicelli C, De Flora A. De Flora S, et al. Carcinogenesis. 1982;3(2):187-94. doi: 10.1093/carcin/3.2.187. Carcinogenesis. 1982. PMID: 6175436
The mutagenicity patterns and the metabolic behaviour of 4 structurally related ICR compounds were investigated using the Salmonella/microsome test. ICR 191 and ICR 170 reverted 4 his- strains (TA1537 greater than TA100 greater than TA98 and TA1538), while ICR 191-O …
The mutagenicity patterns and the metabolic behaviour of 4 structurally related ICR compounds were investigated using the Salmonella/microso …
DNA excision in repair proficient and deficient human cells treated with a combination of ultraviolet radiation and acridine mustard (ICR-170) or 4-nitroquinoline 1-oxide.
Ahmed FE, Setlow RB. Ahmed FE, et al. Chem Biol Interact. 1980 Jan;29(1):31-42. doi: 10.1016/0009-2797(80)90084-8. Chem Biol Interact. 1980. PMID: 6153160
Excision repair was measured in normal human and xeroderma pigmentosum group C fibroblasts treated with ultraviolet radiation and the carcinogens acridine mustard (ICR-170) or 4-nitroquinoline 1-oxide (4NQO) by the techniques of unscheduled synthesis, …
Excision repair was measured in normal human and xeroderma pigmentosum group C fibroblasts treated with ultraviolet radiation and the carcin …
Induction of petite mutations during germination and outgrowth of Saccharomyces cerevisiae ascospores.
Redshaw RA. Redshaw RA. J Bacteriol. 1975 Dec;124(3):1411-6. doi: 10.1128/jb.124.3.1411-1416.1975. J Bacteriol. 1975. PMID: 53231 Free PMC article.
Survival of the ascospores after 2-methoxy-6-chloro-9-(3-[ethyl-2-chloroethyl]aminopropylamino)acridine-2HC1 (ICR-170) treatment was constant from 0 to 5 h, but as the ascospores completed outgrowth at 6 h they became more sensitive to killing by ICR-170 …
Survival of the ascospores after 2-methoxy-6-chloro-9-(3-[ethyl-2-chloroethyl]aminopropylamino)acridine-2HC1 (ICR-170) treatme …
Effect of N2 on the mutagenic and lethal activities of ICR-170 in Neurospora crassa.
Whong WZ. Whong WZ. Mutat Res. 1979 May;60(3):301-12. doi: 10.1016/0027-5107(79)90020-4. Mutat Res. 1979. PMID: 90338
The characteristics of the N2 effect for ICR-170 were that (1) the N2 effect with ICR-170 was displayed in conidia when N2 was administered during, but not before or after, ICR-170 treatment, (2) the highly increased mutagenic and lethal …
The characteristics of the N2 effect for ICR-170 were that (1) the N2 effect with ICR-170 was displayed in conid …
Mutants of yeast defective in iso-1-cytochrome c.
Sherman F, Stewart JW, Jackson M, Gilmore RA, Parker JH. Sherman F, et al. Genetics. 1974 Jun;77(2):255-84. doi: 10.1093/genetics/77.2.255. Genetics. 1974. PMID: 4367877 Free PMC article.
Complementation tests of 6,520 chlorolactate-resistant mutants that were obtained spontaneously or induced with UV, ICR-170, or nitrosoimidazolidone resulted in the identification of 195 mutations at the cyc1 locus, which controls the primary structure of iso-1-cyto …
Complementation tests of 6,520 chlorolactate-resistant mutants that were obtained spontaneously or induced with UV, ICR-170, o …
Mutagenicity of some intercalating agents in Chinese hamster V79 cells.
O'Donovan MR. O'Donovan MR. Mutat Res. 1984 Aug-Sep;137(2-3):117-22. doi: 10.1016/0165-1218(84)90100-9. Mutat Res. 1984. PMID: 6472323
ICR 170 and ICR 191, but not 9-aminoacridine or chloroquine, induced both 6-thioguanine- and, to a smaller extent, ouabain-resistance in Chinese hamster V79 cells. These results indicate that covalent binding to DNA is necessary for intercalating agents to induce mu …
ICR 170 and ICR 191, but not 9-aminoacridine or chloroquine, induced both 6-thioguanine- and, to a smaller extent, ouabain-res …
Mutagenesis at the ad-3A and ad-3B loci in haploid UV-sensitive strains of Neurospora crassa. IV. Comparison of dose-response curves for MNNG, 4NQO and ICR-170 induced inactivation and mutation-induction.
Inoue H, Ong TM, de Serres FJ. Inoue H, et al. Mutat Res. 1981 Jan;80(1):27-41. doi: 10.1016/0027-5107(81)90175-5. Mutat Res. 1981. PMID: 6163076
In contrast to the effects on inactivation, a wide variety of effects were found for the induction of ad-3A and ad-3B mutations: higher forward-mutation frequencies than were found in wild-type were obtained after treatment with MNNG or 4NQO for upr-1 and uvs-2, no significant in …
In contrast to the effects on inactivation, a wide variety of effects were found for the induction of ad-3A and ad-3B mutations: higher forw …
Frameshifts and frameshift suppressors in Saccharomyces cerevisiae.
Culbertson MR, Charnas L, Johnson MT, Fink GR. Culbertson MR, et al. Genetics. 1977 Aug;86(4):745-64. doi: 10.1093/genetics/86.4.745. Genetics. 1977. PMID: 72702 Free PMC article.
Using ICR-170 as a mutagen, we have induced a set of mutations in yeast which exhibit behavior similar to that shown for bacterial frameshift mutations. ...
Using ICR-170 as a mutagen, we have induced a set of mutations in yeast which exhibit behavior similar to that shown for bacte …
Alleviation of mutagenic effects of polycyclic aromatic agents (quinacrine mustard, ICR-191 and ICR-170) by caffeine and pentoxifylline.
Piosik J, Ulanowska K, Gwizdek-Wiśniewska A, Czyz A, Kapuściński J, Wegrzyn G. Piosik J, et al. Mutat Res. 2003 Sep 29;530(1-2):47-57. doi: 10.1016/s0027-5107(03)00136-2. Mutat Res. 2003. PMID: 14563530
Here we demonstrate that caffeine and another xanthine, pentoxifylline (PTX), effectively alleviate mutagenic action of polycyclic aromatic agents (exemplified by quinacrine mustard (QM), 2-methoxy-6-chloro-9-(3-(2-chloroethyl)aminopropylamino)acridine.2HCl (ICR-191) and 1,3,7-pr …
Here we demonstrate that caffeine and another xanthine, pentoxifylline (PTX), effectively alleviate mutagenic action of polycyclic aromatic …
92 results