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Hernandulcin Production in Cell Suspensions of Phyla Scaberrima: Exploring Hernandulcin Accumulation through Physical and Chemical Stimuli.
Villa-Ruano N, Castro-Juárez CJ, Lozoya-Gloria E, Ramírez-García SA, Cruz-Durán R, Varela-Caselis JL. Villa-Ruano N, et al. Chem Biodivers. 2021 Nov;18(11):e2100611. doi: 10.1002/cbdv.202100611. Epub 2021 Oct 13. Chem Biodivers. 2021. PMID: 34547168
Hernandulcin (HE) is a non-caloric sweetener synthesized by the Mexican medicinal plant Phyla scaberrima. ...
Hernandulcin (HE) is a non-caloric sweetener synthesized by the Mexican medicinal plant Phyla scaberrima. ...
Stereoselective synthesis of hernandulcin, peroxylippidulcine A, lippidulcines A, B and C and taste evaluation.
Rigamonti MG, Gatti FG. Rigamonti MG, et al. Beilstein J Org Chem. 2015 Nov 5;11:2117-24. doi: 10.3762/bjoc.11.228. eCollection 2015. Beilstein J Org Chem. 2015. PMID: 26664632 Free PMC article.
The first stereoselective synthesis of lippidulcines A, B and C has been accomplished starting from (+)-hernandulcin, which has been prepared on a multigram scale. The previously assigned absolute configurations have been confirmed. ...
The first stereoselective synthesis of lippidulcines A, B and C has been accomplished starting from (+)-hernandulcin, which has been …
Essential oil from leaves of Lippia dulcis grown in Colombia.
Moreno-Murillo B, Quijano-Célis C, Romero AR, Pino JA. Moreno-Murillo B, et al. Nat Prod Commun. 2010 Apr;5(4):613-4. Nat Prod Commun. 2010. PMID: 20433082
Forty volatile compounds were identified, of which the major ones were alpha-copaene (18.0%), beta-caryophyllene (17.8%), and delta-cadinene (14.7%). The sweet bisabolane sesquiterpenoid, hernandulcin, formed only 1.1% of the leaf oil....
Forty volatile compounds were identified, of which the major ones were alpha-copaene (18.0%), beta-caryophyllene (17.8%), and delta-cadinene …
Molecular cloning and characterization of (+)-epi-alpha-bisabolol synthase, catalyzing the first step in the biosynthesis of the natural sweetener, hernandulcin, in Lippia dulcis.
Attia M, Kim SU, Ro DK. Attia M, et al. Arch Biochem Biophys. 2012 Nov 1;527(1):37-44. doi: 10.1016/j.abb.2012.07.010. Epub 2012 Jul 31. Arch Biochem Biophys. 2012. PMID: 22867794
Hernandulcin, a C15 sesquiterpene ketone, is a natural sweetener isolated from the leaves of Lippia dulcis. It is a promising sugar substitute due to its safety and low caloric potential. However, the biosynthesis of hernandulcin in L. dulcis remains unknown. The fi …
Hernandulcin, a C15 sesquiterpene ketone, is a natural sweetener isolated from the leaves of Lippia dulcis. It is a promising sugar s …
Hernandulcin: an intensely sweet compound discovered by review of ancient literature.
Compadre CM, Pezzuto JM, Kinghorn AD, Kamath SK. Compadre CM, et al. Science. 1985 Jan 25;227(4685):417-9. doi: 10.1126/science.3880922. Science. 1985. PMID: 3880922
., a sweet plant, emerged as a candidate for fractionation studies, and hernandulcin, a sesquiterpene, was isolated and judged by a human taste panel as more than 1000 times sweeter than sucrose. The structure of the sesquiterpene was determined spectroscopically and confi …
., a sweet plant, emerged as a candidate for fractionation studies, and hernandulcin, a sesquiterpene, was isolated and judged by a h …
Analysis of structural features responsible for the sweetness of the sesquiterpene, hernandulcin.
Compadre CM, Hussain RA, Lopez de Compadre RL, Pezzuto JM, Kinghorn AD. Compadre CM, et al. Experientia. 1988 May 15;44(5):447-9. doi: 10.1007/BF01940543. Experientia. 1988. PMID: 3371450
The relationship between sweetness and structure was studied for several analogues of the intensely sweet sesquiterpene, hernandulcin. These derivatives were prepared synthetically, and were spectroscopic and conformational analysis. ...In the course of a preliminary safet …
The relationship between sweetness and structure was studied for several analogues of the intensely sweet sesquiterpene, hernandulcin …
Synthetic Derivatives of (+)-epi-α-Bisabolol Are Formed by Mammalian Cytochromes P450 Expressed in a Yeast Reconstituted Pathway.
Sarrade-Loucheur A, Ro DK, Fauré R, Remaud-Siméon M, Truan G. Sarrade-Loucheur A, et al. ACS Synth Biol. 2020 Feb 21;9(2):368-380. doi: 10.1021/acssynbio.9b00399. Epub 2020 Feb 4. ACS Synth Biol. 2020. PMID: 31977190 Free article.
In this paper, we have tested the ability of a series of human and animal cytochromes P450 involved in xenobiotic detoxification to generate derivatives of (+)-epi-alpha-bisabolol and attempt to produce the direct precursor of hernandulcin, a sweetener from Lippia dulcis f …
In this paper, we have tested the ability of a series of human and animal cytochromes P450 involved in xenobiotic detoxification to generate …
Hernandulcin Production in Elicited Hairy Roots of Phyla scaberrima: Toward Sustainable Production of a Non-Caloric Sweetener with Nutraceutical Properties.
Castro-Juárez CJ, Luna-Suárez S, de Fátima Rosas-Cárdenas F, Villa-Ruano N. Castro-Juárez CJ, et al. Chem Biodivers. 2024 Mar;21(3):e202302095. doi: 10.1002/cbdv.202302095. Epub 2024 Feb 23. Chem Biodivers. 2024. PMID: 38334300
Herein we report on the generation of hairy root lines of P. scaberrima able to produce hernandulcin (HE), a non-caloric sweetener with nutraceutical properties. ...
Herein we report on the generation of hairy root lines of P. scaberrima able to produce hernandulcin (HE), a non-caloric sweetener wi …
(+)-4 beta-hydroxyhernandulcin, a new sweet sesquiterpene from the leaves and flowers of Lippia dulcis.
Kaneda N, Lee IS, Gupta MP, Soejarto DD, Kinghorn AD. Kaneda N, et al. J Nat Prod. 1992 Aug;55(8):1136-41. doi: 10.1021/np50086a016. J Nat Prod. 1992. PMID: 1431936
From the leaves and flowers of Lippia dulcis collected in Panama, a new sweet sesquiterpene identified as (+)-4 beta-hydroxyhernandulcin [2] was isolated, accompanied by (+)-hernandulcin [1], (-)-epihernandulcin [3] (a novel natural product), and 6-methyl-5-hepten-2-one [4 …
From the leaves and flowers of Lippia dulcis collected in Panama, a new sweet sesquiterpene identified as (+)-4 beta-hydroxyhernandulcin [2] …
17 results