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Year Number of Results
1989 2
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1993 18
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1996 80
1997 90
1998 133
1999 159
2000 215
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2002 231
2003 273
2004 262
2005 262
2006 289
2007 254
2008 259
2009 252
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2012 249
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5,187 results

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Page 1
Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42.
Shinjo K, Koland JG, Hart MJ, Narasimhan V, Johnson DI, Evans T, Cerione RA. Shinjo K, et al. Proc Natl Acad Sci U S A. 1990 Dec;87(24):9853-7. doi: 10.1073/pnas.87.24.9853. Proc Natl Acad Sci U S A. 1990. PMID: 2124704 Free PMC article.
We have isolated cDNA clones from a human placental library that code for a low molecular weight GTP-binding protein originally designated Gp (also called G25K). ...The highest degree of sequence identity (80%) is found with the Saccharomyces cerevisia …
We have isolated cDNA clones from a human placental library that code for a low molecular weight GTP-binding protein or …
GTP-stimulated carboxyl methylation of a soluble form of the GTP-binding protein G25K in brain.
Backlund PS Jr. Backlund PS Jr. J Biol Chem. 1992 Sep 15;267(26):18432-9. J Biol Chem. 1992. PMID: 1526984 Free article.
The M(r) 23,000 methyl-acceptor protein was identified as a soluble form of the GTP-binding protein G25K, based on antibody reactivity and amino acid sequences of tryptic peptides. ...The association of the M(r) 28,000 protein with G25 …
The M(r) 23,000 methyl-acceptor protein was identified as a soluble form of the GTP-binding protein G25K, …
ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer.
Hodder S, Fox M, Binti Ahmad Mokhtar AM, Mott HR, Owen D. Hodder S, et al. Small GTPases. 2023 Dec;14(1):14-25. doi: 10.1080/21541248.2023.2212573. Small GTPases. 2023. PMID: 37194323 Free PMC article. Review.
Activated Cdc42-associated kinase (ACK), a non-receptor tyrosine kinase, is an effector for the small GTPase Cdc42. ...ACK is also being increasingly recognized as a potentially influential player in the regulation of protein homoeostasis. The delicate equili …
Activated Cdc42-associated kinase (ACK), a non-receptor tyrosine kinase, is an effector for the small GTPase Cdc42. ...ACK is …
The Growing Spectrum of Human Diseases Caused by Inherited CDC42 Mutations.
Su HC, Orange JS. Su HC, et al. J Clin Immunol. 2020 May;40(4):551-553. doi: 10.1007/s10875-020-00785-8. J Clin Immunol. 2020. PMID: 32417998 Free PMC article.
Several recent studies provide valuable new information that expands the spectrum of human disease associated with mutations in CDC42....
Several recent studies provide valuable new information that expands the spectrum of human disease associated with mutations in CDC42 …
Targeting Rac and Cdc42 GTPases in Cancer.
Maldonado MDM, Dharmawardhane S. Maldonado MDM, et al. Cancer Res. 2018 Jun 15;78(12):3101-3111. doi: 10.1158/0008-5472.CAN-18-0619. Epub 2018 Jun 1. Cancer Res. 2018. PMID: 29858187 Free PMC article. Review.
With the exception of the P29S driver mutation in melanoma, Rac and Cdc42 are not generally mutated in cancer, but are overexpressed (gene amplification and mRNA upregulation) or hyperactivated. ...Therefore, an understanding of the regulatory mechanisms of these pivotal s …
With the exception of the P29S driver mutation in melanoma, Rac and Cdc42 are not generally mutated in cancer, but are overexpressed …
The interdependence of the Rho GTPases and apicobasal cell polarity.
Mack NA, Georgiou M. Mack NA, et al. Small GTPases. 2014;5(2):10. doi: 10.4161/21541248.2014.973768. Small GTPases. 2014. PMID: 25469537 Free PMC article. Review.
Here we review the relationships between the Rho family GTPases and epithelial AB polarization events, focusing on the 3 best-characterized members: Rho, Rac and Cdc42. We discuss a multitude of processes that are important for AB polarization, including lumen formation, a …
Here we review the relationships between the Rho family GTPases and epithelial AB polarization events, focusing on the 3 best-characterized …
Cdc42: Role in Cancer Management.
Qadir MI, Parveen A, Ali M. Qadir MI, et al. Chem Biol Drug Des. 2015 Oct;86(4):432-9. doi: 10.1111/cbdd.12556. Epub 2015 Apr 7. Chem Biol Drug Des. 2015. PMID: 25777055 Review.
Therefore, maintaining the level of Cdc42 and its effectors in cells, tumor progression can be controlled. Therefore, it can be suggested that deeper understanding about the Cdc42 contribution in cancer cell progression at molecular level can approach to the develop …
Therefore, maintaining the level of Cdc42 and its effectors in cells, tumor progression can be controlled. Therefore, it can be sugge …
Cdc42 oscillations in yeasts.
Bendezú FO, Martin SG. Bendezú FO, et al. Sci Signal. 2012 Dec 4;5(253):pe53. doi: 10.1126/scisignal.2003630. Sci Signal. 2012. PMID: 23211526 Review.
Through mechanisms involving positive and negative feedback, the small Rho-family guanosine triphosphatase Cdc42 breaks symmetry in round budding yeast cells to define a single site of polarized cell growth. ...We discuss a study in which rod-shaped fission yeast cells, wh …
Through mechanisms involving positive and negative feedback, the small Rho-family guanosine triphosphatase Cdc42 breaks symmetry in r …
Progress in the therapeutic inhibition of Cdc42 signalling.
Murphy NP, Mott HR, Owen D. Murphy NP, et al. Biochem Soc Trans. 2021 Jun 30;49(3):1443-1456. doi: 10.1042/BST20210112. Biochem Soc Trans. 2021. PMID: 34100887 Free PMC article. Review.
As a regulator of both cell architecture and motility, deregulation of Cdc42 is also linked to tumour metastasis. Like Ras, Cdc42 and other components of the signalling pathways it controls represent important potential targets for cancer therapeutics. ...Strategies …
As a regulator of both cell architecture and motility, deregulation of Cdc42 is also linked to tumour metastasis. Like Ras, Cdc42 …
Embracing Noise in Chemical Reaction Networks.
Enciso G, Kim J. Enciso G, et al. Bull Math Biol. 2019 May;81(5):1261-1267. doi: 10.1007/s11538-019-00575-3. Bull Math Biol. 2019. PMID: 30734148 Review.
5,187 results