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Year Number of Results
1991 1
1994 1
1995 1
1996 1
1997 1
1998 4
1999 2
2001 2
2002 1
2003 1
2004 1
2006 2
2007 2
2009 1
2010 5
2011 2
2012 2
2013 1
2014 4
2015 6
2016 3
2017 8
2018 2
2019 4
2020 2
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2023 3
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62 results

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Page 1
Novel approach using [(18)F]FTHA-PET and de novo synthesized VLDL for assessment of FFA metabolism in a rat model of diet induced NAFLD.
Ustsinau U, Ehret V, Fürnsinn C, Scherer T, Helbich TH, Hacker M, Krššák M, Philippe C. Ustsinau U, et al. Clin Nutr. 2023 Oct;42(10):1839-1848. doi: 10.1016/j.clnu.2023.08.001. Epub 2023 Aug 8. Clin Nutr. 2023. PMID: 37625314 Free article.
To measure hepatic FFA uptake, rats underwent 60 min dynamic [(18)F]FTHA-PET scans after unrestricted access to food (HFD: n = 6; SD: n = 6) or overnight (16h) fasting (HFD: n = 6; SD: n = 5). ...CONCLUSION: Our novel approach for assessing FFA metabolism using [(18)F]F …
To measure hepatic FFA uptake, rats underwent 60 min dynamic [(18)F]FTHA-PET scans after unrestricted access to food (HFD: n = 6; SD: …
Automated production of [(18) F]FTHA according to GMP.
Savisto N, Viljanen T, Kokkomäki E, Bergman J, Solin O. Savisto N, et al. J Labelled Comp Radiopharm. 2018 Feb;61(2):84-93. doi: 10.1002/jlcr.3589. Epub 2018 Feb 22. J Labelled Comp Radiopharm. 2018. PMID: 29205456
Visualizing increased uptake of [18F]FDG and [18F]FTHA in kidneys from obese high-fat diet fed C57BL/6J mice using PET/CT ex vivo.
Nyrén R, Scherman H, Axelsson J, Chang CL, Olivecrona G, Ericsson M. Nyrén R, et al. PLoS One. 2023 Feb 14;18(2):e0281705. doi: 10.1371/journal.pone.0281705. eCollection 2023. PLoS One. 2023. PMID: 36787333 Free PMC article.
The ex vivo protocol reduced interfering background as well as interindividual variances. We found increased uptake of [18F]FDG and [18F]FTHA in kidneys after HFD, compared to kidneys from young mice on standard chow. ...Obesity and insulin resistance induced by HFD increa …
The ex vivo protocol reduced interfering background as well as interindividual variances. We found increased uptake of [18F]FDG and [18F] …
Comparison of fatty acid tracers FTHA and BMIPP during myocardial ischemia and hypoxia.
Renstrom B, Rommelfanger S, Stone CK, DeGrado TR, Carlson KJ, Scarbrough E, Nickles RJ, Liedtke AJ, Holden JE. Renstrom B, et al. J Nucl Med. 1998 Oct;39(10):1684-9. J Nucl Med. 1998. PMID: 9776269 Free article.
However, in the hypoxia group, FTHA uptake was unchanged, whereas BMIPP retention increased compared to the circumflex arterial bed. CONCLUSION: Decreased retention of both BMIPP and FTHA occurred with ischemia, despite the known differences in metabolism of the two …
However, in the hypoxia group, FTHA uptake was unchanged, whereas BMIPP retention increased compared to the circumflex arterial bed. …
A Fully Automated Synthesis of 14-(R,S)-[(18)F]fluoro-6-thia-heptadecanoic Acid ([(18)F]FTHA) on the Elixys Radiosynthesizer.
Ustsinau U, Nics L, Hacker M, Philippe C. Ustsinau U, et al. Pharmaceuticals (Basel). 2024 Feb 29;17(3):318. doi: 10.3390/ph17030318. Pharmaceuticals (Basel). 2024. PMID: 38543104 Free PMC article.
14-(R,S)-[(18)F]fluoro-6-thia-heptadecanoic acid ([(18)F]FTHA) is a radiocompound for imaging the fatty acid circulation by positron emission tomography. A revived interest in imaging of lipid metabolism led us to a constant tracer production over three years, initially us …
14-(R,S)-[(18)F]fluoro-6-thia-heptadecanoic acid ([(18)F]FTHA) is a radiocompound for imaging the fatty acid circulation by positron …
Biodistribution of the fatty acid analogue 18F-FTHA: plasma and tissue partitioning between lipid pools during fasting and hyperinsulinemia.
Guiducci L, Grönroos T, Järvisalo MJ, Kiss J, Viljanen A, Naum AG, Viljanen T, Savunen T, Knuuti J, Ferrannini E, Salvadori PA, Nuutila P, Iozzo P. Guiducci L, et al. J Nucl Med. 2007 Mar;48(3):455-62. J Nucl Med. 2007. PMID: 17332624 Free article.
Radioactivity was assessed in the FA, phospholipid, and triglyceride or glycerol ester pools. RESULTS: The tissue-to-plasma intact (18)F-FTHA ratio was high in all tissues, with the highest values being in the heart and liver; (18)F-FTHA accumulated in the brain to …
Radioactivity was assessed in the FA, phospholipid, and triglyceride or glycerol ester pools. RESULTS: The tissue-to-plasma intact (18)F- …
Radiation induced oxidation of [18F]fluorothia fatty acids under cGMP manufacturing conditions.
Pandey MK, Jacobson MS, Groth EK, Tran NG, Lowe VJ, DeGrado TR. Pandey MK, et al. Nucl Med Biol. 2020 Jan-Feb;80-81:13-23. doi: 10.1016/j.nucmedbio.2019.11.004. Epub 2019 Nov 9. Nucl Med Biol. 2020. PMID: 31759313 Free PMC article.
OBJECTIVE: The objectives of the present work were to optimize and validate the synthesis and stability of 14(R,S)-[(18)F]fluoro-6-thia-heptadecanoic acid ([(18)F]FTHA) and 16-[(18)F]fluoro-4-thia-palmitic acid ([(18)F]FTP) under cGMP conditions for clinical applications. …
OBJECTIVE: The objectives of the present work were to optimize and validate the synthesis and stability of 14(R,S)-[(18)F]fluoro-6-thia-hept …
Imaging of beta-oxidation by static PET with 14(R,S)-[18F]-fluoro-6-thiaheptadecanoic acid (FTHA) in patients with advanced coronary heart disease: a comparison with 18FDG-PET and 99Tcm-MIBI SPET.
Schulz G, von Dahl J, Kaiser HJ, Koch KC, Sabri O, Banneitz L, Cremerius U, Buell U. Schulz G, et al. Nucl Med Commun. 1996 Dec;17(12):1057-64. doi: 10.1097/00006231-199612000-00010. Nucl Med Commun. 1996. PMID: 9004303
FTHA uptake paralleled MIBI uptake (r = 0.80) but not FDG uptake (r = 0.57). ...The similarity between FTHA and MIBI uptake suggests that static PET imaging with FTHA is of limited value when distinguishing between ischaemic or hibernating myocardium and scar …
FTHA uptake paralleled MIBI uptake (r = 0.80) but not FDG uptake (r = 0.57). ...The similarity between FTHA and MIBI uptake su …
14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid (FTHA): evaluation in mouse of a new probe of myocardial utilization of long chain fatty acids.
DeGrado TR, Coenen HH, Stocklin G. DeGrado TR, et al. J Nucl Med. 1991 Oct;32(10):1888-96. J Nucl Med. 1991. PMID: 1919727 Free article.
14(R,S)-[18F]Fluoro-6-thia-heptadecanoic acid (FTHA) is a new radiolabeled long-chain fatty acid (LCFA) analog designed to undergo metabolic trapping subsequent to its commitment to the beta-oxidation pathway. ...Radioanalytical studies showed the major metabolic fate of …
14(R,S)-[18F]Fluoro-6-thia-heptadecanoic acid (FTHA) is a new radiolabeled long-chain fatty acid (LCFA) analog designed to undergo me …
Hepatic Positron Emission Tomography: Applications in Metabolism, Haemodynamics and Cancer.
Honka MJ, Rebelos E, Malaspina S, Nuutila P. Honka MJ, et al. Metabolites. 2022 Apr 2;12(4):321. doi: 10.3390/metabo12040321. Metabolites. 2022. PMID: 35448508 Free PMC article. Review.
Its application not only enables the evaluation of hepatic glucose uptake in a variety of metabolic conditions and interventions, but based on the kinetics of (18)F-FDG, endogenous glucose production can also be assessed. 14(R,S)-[(18)F]fluoro-6-thia-Heptadecanoic acid ((18)F- …
Its application not only enables the evaluation of hepatic glucose uptake in a variety of metabolic conditions and interventions, but based …
62 results