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Page 1
[3H]ohmefentanyl preferentially binds to mu-opioid receptors but also labels sigma-sites in rat brain sections.
Wang H, Pélaprat D, Roques BP, Vanhove A, Chi ZQ, Rostène W. Wang H, et al. Eur J Pharmacol. 1991 Feb 14;193(3):341-50. doi: 10.1016/0014-2999(91)90149-k. Eur J Pharmacol. 1991. PMID: 1647320
Ohmefentanyl has been shown to be 6300 times more potent than morphine for analgesia. ...Haloperidol and 1,3-di-o-tolylguanidine were able to inhibit DAGO-inaccessible [3H]ohmefentanyl specific binding, suggesting that [3H]ohmefentanyl might also bind to halo …
Ohmefentanyl has been shown to be 6300 times more potent than morphine for analgesia. ...Haloperidol and 1,3-di-o-tolylguanidine were …
Comparison of physical dependence of ohmefentanyl stereoisomers in mice.
Guo GW, He Y, Jin WQ, Zou Y, Zhu YC, Chi ZQ. Guo GW, et al. Life Sci. 2000;67(2):113-20. doi: 10.1016/s0024-3205(00)00617-2. Life Sci. 2000. PMID: 10901279
Stereo-structural difference of ohmefentanyl stereoisomers on analgesic action and receptor affinity has been studied. To assess the difference of ohmefentanyl stereoisomers in physical dependence, the potency of physical dependence was quantified by estimating the …
Stereo-structural difference of ohmefentanyl stereoisomers on analgesic action and receptor affinity has been studied. To assess the …
Analgesic activity and opioid receptor selectivity of stereoisomers of ohmefentanyl isothiocyanate.
Chen BY, Jin WQ, Chen XJ, Zhu YC, Chi ZQ. Chen BY, et al. Eur J Pharmacol. 2001 Jul 27;424(3):195-8. doi: 10.1016/s0014-2999(01)01172-4. Eur J Pharmacol. 2001. PMID: 11672562
Ohmefentanyl is a very potent and highly selective agonist for mu-opioid receptors. ...However, compared with the activity of the corresponding stereoisomers of ohmefentanyl, these ohmefentanyl isothiocyanates had significantly reduced analgesia and in vitro …
Ohmefentanyl is a very potent and highly selective agonist for mu-opioid receptors. ...However, compared with the activity of the cor …
Quantitative comparison of ohmefentanyl isomers induced conditioning place preference in mice.
Guo GW, Liu ZH, Jin WQ, Zhang HP, Chen XJ, Zhu YC, Chi ZQ. Guo GW, et al. Life Sci. 2001 Apr 13;68(21):2383-90. doi: 10.1016/s0024-3205(01)01030-x. Life Sci. 2001. PMID: 11350009
Differences of analgesia and withdrawal response among ohmefentanyl stereoisomers have been studied. In the present study, Quantitative comparison of reinforcing effects of ohmefentanyl stereoisomers and morphine was performed by using a conditioned place preference …
Differences of analgesia and withdrawal response among ohmefentanyl stereoisomers have been studied. In the present study, Quantitati …
Characterization and distribution of [3H]ohmefentanyl binding sites in the human brain.
Wang H, Sarrieau A, Pélaprat D, Roques BP, Vanhove A, Kopp N, Chi ZQ, Rostène W. Wang H, et al. Synapse. 1991 Jul;8(3):177-84. doi: 10.1002/syn.890080305. Synapse. 1991. PMID: 1948668
Binding characteristics and anatomical distribution also show that [3H]ohmefentanyl may bind to a small proportion of additional sites called "DAGO-inaccessible [3H]ohmefentanyl specific binding sites." [3H]Ohmefentanyl binding to these sites can be partly in …
Binding characteristics and anatomical distribution also show that [3H]ohmefentanyl may bind to a small proportion of additional site …
Monoclonal antibodies specific for ohmefentanyl.
Lu YF, Tong CX, Wei AL, Lin SY, Chen XJ, Zhou DH, Chi ZQ. Lu YF, et al. Zhongguo Yao Li Xue Bao. 1994 Jul;15(4):303-7. Zhongguo Yao Li Xue Bao. 1994. PMID: 7801768 Free article.
Ohmefentanyl (Ohm, N[1-(beta-hydroxy-beta-phenylethyl)-3-methyl-4- piperidyl]-N-phenylpro-pronamide), designed and synthesized by our laboratory, is a highly selective mu receptor agonist. ...
Ohmefentanyl (Ohm, N[1-(beta-hydroxy-beta-phenylethyl)-3-methyl-4- piperidyl]-N-phenylpro-pronamide), designed and synthesized by our …
Effect of brain lesions on [3H]ohmefentanyl binding site densities in the rat striatum and substantia nigra.
Masuo Y, Wang H, Pélaprat D, Chi ZQ, Rostène W. Masuo Y, et al. Chem Pharm Bull (Tokyo). 1992 Sep;40(9):2520-4. doi: 10.1248/cpb.40.2520. Chem Pharm Bull (Tokyo). 1992. PMID: 1332831
We have recently demonstrated that [3H]ohmefentanyl, a non-peptidergic opioid ligand which was suggested to cross the blood brain barrier in contrast to other peptidergic opioid ligands, bound not only to mu opioid receptor sites but also to sigma sites. In order to examin …
We have recently demonstrated that [3H]ohmefentanyl, a non-peptidergic opioid ligand which was suggested to cross the blood brain bar …
Internalization and recycling of human mu opioid receptors expressed in Sf9 insect cells.
Chen LE, Gao C, Chen J, Xu XJ, Zhou DH, Chi ZQ. Chen LE, et al. Life Sci. 2003 May 23;73(1):115-28. doi: 10.1016/s0024-3205(03)00250-9. Life Sci. 2003. PMID: 12726892
Ohmefentanyl-induced human mu opioid receptor internalization was concentration-dependent, with about 40% of the receptors internalized following a 30-min exposure to 1 microM ohmefentanyl. 10 microM morphine and 1 microM DAMGO could also induce about 40% internaliz …
Ohmefentanyl-induced human mu opioid receptor internalization was concentration-dependent, with about 40% of the receptors internaliz …
Ohmefentanyl--a new agonist for mu-opiate receptor.
Xu H, Chen J, Chi ZQ. Xu H, et al. Sci Sin B. 1985 May;28(5):504-11. Sci Sin B. 1985. PMID: 2996128
Ohmefentanyl (F 7302, N[1-(beta-hydroxy-beta-phenylethyl)-3-methyl-4-piperidyl]-N -phenylpropionamide) is a potent synthetic analgesic agent. ...This suggests that ohmefentanyl has potent mu-agonist properties....
Ohmefentanyl (F 7302, N[1-(beta-hydroxy-beta-phenylethyl)-3-methyl-4-piperidyl]-N -phenylpropionamide) is a potent synt …
Heptapeptide mimic of ohmefentanyl binding in the discontinuous mu-opiod receptor.
Gawley RE, Dukh M, Cardona CM, Jannach SH, Greathouse D. Gawley RE, et al. Org Lett. 2005 Jul 7;7(14):2953-6. doi: 10.1021/ol0509179. Org Lett. 2005. PMID: 15987178
[reaction: see text] Ohmefentanyl binds to the rat mu-opiod receptor via two dipeptide sequences (Trp-His and Asp-Tyr) that are separated by 170 residues. A turn-inducing tripeptide, Pro-Aib-Aib, holds the dipeptides in a conformation that binds the narcotic (K(b) = 7.1 x …
[reaction: see text] Ohmefentanyl binds to the rat mu-opiod receptor via two dipeptide sequences (Trp-His and Asp-Tyr) that are separ …
89 results