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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 1
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1959 1
1960 1
1962 1
1965 1
1968 1
1973 1
1976 2
1977 1
1978 1
1980 2
1981 2
1982 3
1983 2
1984 8
1985 10
1986 16
1987 10
1988 10
1989 12
1990 4
1991 8
1992 11
1993 12
1994 15
1995 13
1996 19
1997 7
1998 8
1999 11
2000 15
2001 17
2002 14
2003 10
2004 16
2005 15
2006 11
2007 22
2008 20
2009 25
2010 19
2011 24
2012 22
2013 26
2014 33
2015 36
2016 39
2017 41
2018 30
2019 33
2020 43
2021 53
2022 44
2023 55
2024 26

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796 results

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Page 1
Esculetin: A review of its pharmacology and pharmacokinetics.
Zhang L, Xie Q, Li X. Zhang L, et al. Phytother Res. 2022 Jan;36(1):279-298. doi: 10.1002/ptr.7311. Epub 2021 Nov 22. Phytother Res. 2022. PMID: 34808701 Review.
Esculetin is a natural dihydroxy coumarin; it is mainly extracted from twig skin and the trunk bark of the Chinese herbal medicine Fraxinus rhynchophylla Hance. ...The oral bioavailability of esculetin was shown by studies to be low. The extensive glucuronidation wa …
Esculetin is a natural dihydroxy coumarin; it is mainly extracted from twig skin and the trunk bark of the Chinese herbal medicine Fr …
Pharmacological and Therapeutic Applications of Esculetin.
Garg SS, Gupta J, Sahu D, Liu CJ. Garg SS, et al. Int J Mol Sci. 2022 Oct 20;23(20):12643. doi: 10.3390/ijms232012643. Int J Mol Sci. 2022. PMID: 36293500 Free PMC article. Review.
Esculetin is a coumarin compound, which belongs to the class of benzopyrone enriched in various plants such as Sonchus grandifolius, Aesculus turbinata, etc. ...Structurally, esculetin contains two hydroxyl groups, which enhance its ability to function as an antioxi …
Esculetin is a coumarin compound, which belongs to the class of benzopyrone enriched in various plants such as Sonchus grandifolius, …
Pharmacological Activities and Synthesis of Esculetin and Its Derivatives: A Mini-Review.
Liang C, Ju W, Pei S, Tang Y, Xiao Y. Liang C, et al. Molecules. 2017 Mar 2;22(3):387. doi: 10.3390/molecules22030387. Molecules. 2017. PMID: 28257115 Free PMC article. Review.
Esculetin, synonymous with 6,7-dihydroxycoumarin, is the main active ingredient of the traditional Chinese medicine Cortex Fraxini. ...This mini-review will consolidate what is known about the biological activities, the mechanism of esculetin and its synthetic deriv …
Esculetin, synonymous with 6,7-dihydroxycoumarin, is the main active ingredient of the traditional Chinese medicine Cortex Fraxini. . …
Therapeutic efficacy of mitochondria-targeted esculetin in the improvement of NAFLD-NASH via modulating AMPK-SIRT1 axis.
Singuru G, Pulipaka S, Shaikh A, Balaji Andugulapati S, Thennati R, Kotamraju S. Singuru G, et al. Int Immunopharmacol. 2023 Nov;124(Pt B):111070. doi: 10.1016/j.intimp.2023.111070. Epub 2023 Oct 18. Int Immunopharmacol. 2023. PMID: 37862737
Mitochondrial dysfunction due to deregulated production of mitochondria-derived ROS is implicated in the development and progression of non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH). Recently, we synthesized a novel mitochondria-targeted esc …
Mitochondrial dysfunction due to deregulated production of mitochondria-derived ROS is implicated in the development and progression of non- …
Pharmacological activities of esculin and esculetin: A review.
Cai T, Cai B. Cai T, et al. Medicine (Baltimore). 2023 Oct 6;102(40):e35306. doi: 10.1097/MD.0000000000035306. Medicine (Baltimore). 2023. PMID: 37800835 Free PMC article. Review.
Esculin and esculetin are 2 widely studied coumarin components of Cortex Fraxini, which is a well-known herbal medicine with a 2000-year history. ...This review aims to provide comprehensive information on pharmacological studies of esculin and esculetin, which is o …
Esculin and esculetin are 2 widely studied coumarin components of Cortex Fraxini, which is a well-known herbal medicine with a 2000-y …
Esculetin: A phytochemical endeavor fortifying effect against non-communicable diseases.
Kadakol A, Sharma N, Kulkarni YA, Gaikwad AB. Kadakol A, et al. Biomed Pharmacother. 2016 Dec;84:1442-1448. doi: 10.1016/j.biopha.2016.10.072. Epub 2016 Oct 31. Biomed Pharmacother. 2016. PMID: 27810338 Review.
Esculetin, a naturally occurring 6,7-dihydroxy derivative of coumarin has shown its potential role in various non-communicable diseases (NCDs) including obesity, diabetes, cardiovascular, renal failure, cancer and neurological disorders. ...This may help us in improving ou …
Esculetin, a naturally occurring 6,7-dihydroxy derivative of coumarin has shown its potential role in various non-communicable diseas …
Esculetin Inhibits Cancer Cell Glycolysis by Binding Tumor PGK2, GPD2, and GPI.
Wu ST, Liu B, Ai ZZ, Hong ZC, You PT, Wu HZ, Yang YF. Wu ST, et al. Front Pharmacol. 2020 Mar 27;11:379. doi: 10.3389/fphar.2020.00379. eCollection 2020. Front Pharmacol. 2020. PMID: 32292350 Free PMC article.
We detected the binding constant of the active compound using microscale thermophoresis (MST). It was found that esculetin bound well with three potential target proteins. Esculetin significantly inhibited the rate of glycolysis, manifested by differences of cellula …
We detected the binding constant of the active compound using microscale thermophoresis (MST). It was found that esculetin bound well …
Esculetin induces apoptosis of SMMC-7721 cells through IGF-1/PI3K/Akt-mediated mitochondrial pathways.
Li J, Li S, Wang X, Wang H. Li J, et al. Can J Physiol Pharmacol. 2017 Jul;95(7):787-794. doi: 10.1139/cjpp-2016-0548. Epub 2017 Feb 3. Can J Physiol Pharmacol. 2017. PMID: 28177662
However, the mechanism by which esculetin prevents human hepatic cancer cell growth is still largely unknown. ...In addition, the inactivation of IGF-1, PI3K, and Akt was observed after esculetin administration. Furthermore, pretreatment with IGF-1 before esculet …
However, the mechanism by which esculetin prevents human hepatic cancer cell growth is still largely unknown. ...In addition, the ina …
Attenuation of doxorubicin-induced cardiotoxicity by esculetin through modulation of Bmi-1 expression.
Xu F, Li X, Liu L, Xiao X, Zhang L, Zhang S, Lin P, Wang X, Wang Y, Li Q. Xu F, et al. Exp Ther Med. 2017 Sep;14(3):2216-2220. doi: 10.3892/etm.2017.4763. Epub 2017 Jul 10. Exp Ther Med. 2017. PMID: 28962145 Free PMC article.
The protective effects and mechanisms of esculetin on doxorubicin (DOX)-induced injury of H9c2 cells were investigated. ...Bmi-1 siRNA was used to detect the role of Bmi-1 in the protective effects of esculetin against DOX-induced toxicity in H9c2 cells. The MTT and …
The protective effects and mechanisms of esculetin on doxorubicin (DOX)-induced injury of H9c2 cells were investigated. ...Bmi-1 siRN …
Mitochondria-targeted esculetin mitigates atherosclerosis in the setting of aging via the modulation of SIRT1-mediated vascular cell senescence and mitochondrial function in Apoe(-/-) mice.
Karnewar S, Pulipaka S, Katta S, Panuganti D, Neeli PK, Thennati R, Jerald MK, Kotamraju S. Karnewar S, et al. Atherosclerosis. 2022 Sep;356:28-40. doi: 10.1016/j.atherosclerosis.2022.07.012. Epub 2022 Jul 20. Atherosclerosis. 2022. PMID: 35961209
Mitochondria-targeted anti-oxidants are evolving as a new class of compounds that can alter the pathophysiology of age-related diseases, including atherosclerosis, where mitochondrial dysfunction plays a critical role in disease progression. METHODS: We recently synthesized an al …
Mitochondria-targeted anti-oxidants are evolving as a new class of compounds that can alter the pathophysiology of age-related diseases, inc …
796 results