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1989 3
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Page 1
Epsiprantel, a new tapeworm remedy. Preliminary efficacy studies in dogs and cats.
Manger BR, Brewer MD. Manger BR, et al. Br Vet J. 1989 Jul-Aug;145(4):384-8. doi: 10.1016/0007-1935(89)90038-9. Br Vet J. 1989. PMID: 2775987
The anthelmintic potential of epsiprantel, 2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazin [2,1-a] [2]benzapine, was revealed using the tapeworms Dipylidium caninum and Taenia taeniaeformis in the cat, and Taenia pisiformis and T. hydatigena in the dog. ...
The anthelmintic potential of epsiprantel, 2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazin [2,1-a] [2]benzapine, was …
Developments in the treatment of gastrointestinal parasites of small animals.
Zajac AM. Zajac AM. Vet Clin North Am Small Anim Pract. 1993 May;23(3):671-81. doi: 10.1016/s0195-5616(93)50312-1. Vet Clin North Am Small Anim Pract. 1993. PMID: 8503166 Review.
The spectrum of action, efficacy, and toxicity of benzimidazoles, ivermectin, milbemycin, praziquantel, and epsiprantel are considered....
The spectrum of action, efficacy, and toxicity of benzimidazoles, ivermectin, milbemycin, praziquantel, and epsiprantel are considere …
Praziquantel Resistance in the Zoonotic Cestode Dipylidium caninum.
Jesudoss Chelladurai J, Kifleyohannes T, Scott J, Brewer MT. Jesudoss Chelladurai J, et al. Am J Trop Med Hyg. 2018 Nov;99(5):1201-1205. doi: 10.4269/ajtmh.18-0533. Am J Trop Med Hyg. 2018. PMID: 30226153 Free PMC article.
From 2016 to 2018, a population of dogs with cestode infections that could not be eliminated despite multiple treatments with praziquantel or epsiprantel was identified. Cases of D. caninum were clinically resistant to praziquantel and could not be resolved despite increas …
From 2016 to 2018, a population of dogs with cestode infections that could not be eliminated despite multiple treatments with praziquantel o …
Elimination of probable praziquantel-resistant Dipylidium caninum with nitroscanate in a mixed-breed dog: a case report.
Loftus JP, Acevedo A, Bowman DD, Liotta JL, Wu T, Zhu M. Loftus JP, et al. Parasit Vectors. 2022 Nov 22;15(1):438. doi: 10.1186/s13071-022-05559-2. Parasit Vectors. 2022. PMID: 36419194 Free PMC article.
Observation of the segments confirmed the presence of adult Dipylidium spp in feces. Treatment with praziquantel and epsiprantel were unsuccessful in eliminating the organism but was apparently successful in flea prevention. ...
Observation of the segments confirmed the presence of adult Dipylidium spp in feces. Treatment with praziquantel and epsiprantel were …
[Efficacy evaluation of epsiprantel (Cestex) against Echinococcus mutilocularis in dogs and cats].
Eckert J, Thompson RC, Bucklar H, Bilger B, Deplazes P. Eckert J, et al. Berl Munch Tierarztl Wochenschr. 2001 Mar-Apr;114(3-4):121-6. Berl Munch Tierarztl Wochenschr. 2001. PMID: 11314583 Clinical Trial. German.
Helminth-free dogs and cats were experimentally infected with protoscoleces of Echinococcus multilocularis and used in controlled trials for efficacy evaluation of the cestodicide epsiprantel. In two separate trials each 4 dogs were treated at day 20 post infection (p.i.) …
Helminth-free dogs and cats were experimentally infected with protoscoleces of Echinococcus multilocularis and used in controlled trials for …
Synthesis and anthelmintic activity of a series of pyrazino[2,1-a][2]benzazepine derivatives.
Brewer MD, Burgess MN, Dorgan RJ, Elliott RL, Mamalis P, Manger BR, Webster RA. Brewer MD, et al. J Med Chem. 1989 Sep;32(9):2058-62. doi: 10.1021/jm00129a007. J Med Chem. 1989. PMID: 2769679
Many of these derivatives proved to be highly active, and 2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b- octahydropyrazino[2,1-alpha][2]benzazepine, epsiprantel (BAN) (22), was selected for further development. The structure-activity relationships are discussed....
Many of these derivatives proved to be highly active, and 2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b- octahydropyrazino[2,1-alpha][2]ben …
In vitro and in vivo efficacy of epsiprantel against Echinococcus granulosus.
Thompson RC, Reynoldson JA, Manger BR. Thompson RC, et al. Res Vet Sci. 1991 Nov;51(3):332-4. doi: 10.1016/0034-5288(91)90087-5. Res Vet Sci. 1991. PMID: 1780591 Clinical Trial.
In vitro, epsiprantel at a concentration of 10 micrograms ml-1 caused tegumental damage and death of protoscoleces, juveniles (seven-day-old) and adult (37-day-old) Echinococcus granulosus. Degenerative changes and death occurred more rapidly in the older parasites. Simila …
In vitro, epsiprantel at a concentration of 10 micrograms ml-1 caused tegumental damage and death of protoscoleces, juveniles (seven- …
Dose titration and confirmation tests for determination of cesticidal efficacy of epsiprantel in dogs.
Corwin RM, Green SP, Keefe TJ. Corwin RM, et al. Am J Vet Res. 1989 Jul;50(7):1076-7. Am J Vet Res. 1989. PMID: 2774329
Fifty-five dogs, naturally infected with Taenia sp or Dipylidium caninum or both, were assigned to the following treatment groups for dose titration studies with epsiprantel: nonmedicated control dogs (n = 14), medicated dogs given a dosage of 2.75 mg/kg of body weight (n …
Fifty-five dogs, naturally infected with Taenia sp or Dipylidium caninum or both, were assigned to the following treatment groups for dose t …
Determination of active substances in multicomponent veterinary preparations of antiparasitic action by HPLC method.
Białecka W, Kulik A. Białecka W, et al. Acta Pol Pharm. 2010 Sep-Oct;67(5):463-8. Acta Pol Pharm. 2010. PMID: 20873412 Free article.
The studied compounds included: pyrantel embonate, fenbendazole, praziquantel, epsiprantel and febantel. Using the developed HPLC method, a good separation of the above compounds was achieved. ...
The studied compounds included: pyrantel embonate, fenbendazole, praziquantel, epsiprantel and febantel. Using the developed HPLC met …
Macracanthorhynchus ingens infection in a dog.
Pearce JR, Hendrix CM, Allison N, Butler JM. Pearce JR, et al. J Am Vet Med Assoc. 2001 Jul 15;219(2):194-6. doi: 10.2460/javma.2001.219.194. J Am Vet Med Assoc. 2001. PMID: 11469574 Free article.
Spindle-shaped eggs (mean length, 91 microm; mean width; 54 microm) were obtained from the body cavity of a gravid female specimen. The dog was treated empirically with epsiprantel (5.5 mg/kg [2.5 mg/lb] of body weight) and ivermectin (250 to 500 microg/kg [114 to 227 micr …
Spindle-shaped eggs (mean length, 91 microm; mean width; 54 microm) were obtained from the body cavity of a gravid female specimen. The dog …
12 results