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Year Number of Results
1985 3
1986 4
1987 2
1988 4
1989 2
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1991 4
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1993 2
1995 2
1997 1
2024 0

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Page 1
Competitive antagonism at thromboxane receptors in human platelets.
Armstrong RA, Jones RL, Peesapati V, Will SG, Wilson NH. Armstrong RA, et al. Br J Pharmacol. 1985 Mar;84(3):595-607. doi: 10.1111/j.1476-5381.1985.tb16139.x. Br J Pharmacol. 1985. PMID: 2580580 Free PMC article.
The inhibitory effects of three prostanoid analogues, EP 045, EP 092 and pinane thromboxane A2 (PTA2), on the aggregation of human platelets in vitro have been investigated. ...The block of the stable agonist action was surmountable. In plasma-free platelet suspensi …
The inhibitory effects of three prostanoid analogues, EP 045, EP 092 and pinane thromboxane A2 (PTA2), on the aggregation of h …
Inhibitory effect of a selective thromboxane A2 receptor antagonist, EP 092, on platelet aggregation in whole blood ex vivo and in vivo.
Booth RF, Honey AC, Lad N, Tuffin DP, Wade PJ. Booth RF, et al. Br J Pharmacol. 1989 Feb;96(2):395-405. doi: 10.1111/j.1476-5381.1989.tb11830.x. Br J Pharmacol. 1989. PMID: 2522336 Free PMC article.
Similar potency against collagen-induced whole blood aggregation was observed in Rhesus monkey blood samples following EP 092 given orally (ED50 0.9 +/- 0.3 mg kg-1). 3. The duration of action of EP 092 against collagen aggregatory responses ex vivo in …
Similar potency against collagen-induced whole blood aggregation was observed in Rhesus monkey blood samples following EP 092 …
EP 171: a high affinity thromboxane A2-mimetic, the actions of which are slowly reversed by receptor blockade.
Jones RL, Wilson NH, Lawrence RA. Jones RL, et al. Br J Pharmacol. 1989 Apr;96(4):875-87. doi: 10.1111/j.1476-5381.1989.tb11898.x. Br J Pharmacol. 1989. PMID: 2743082 Free PMC article.
On the pig pulmonary artery, a more rapidly responding preparation, it was possible to show that the TP-receptor antagonist EP 092 blocked the contractile actions of EP 171 and U-46619 to similar extents: pA2 = 8.09 and 8.15 respectively. 4. ...Established responses …
On the pig pulmonary artery, a more rapidly responding preparation, it was possible to show that the TP-receptor antagonist EP 092 …
Heterogeneity of thromboxane A2 (TP-) receptors: evidence from antagonist but not agonist potency measurements.
Tymkewycz PM, Jones RL, Wilson NH, Marr CG. Tymkewycz PM, et al. Br J Pharmacol. 1991 Mar;102(3):607-14. doi: 10.1111/j.1476-5381.1991.tb12220.x. Br J Pharmacol. 1991. PMID: 1364826 Free PMC article.
With U-46619 as agonist, the pA2 values of seven antagonists were found to be very similar on human and rat platelets. The potency ranking was EP 169 > AH 23848 > EP 092 > ONO 11120 > EP 115 = 16,20-methano PTA2 > BM 13177. There was a similar trend o …
With U-46619 as agonist, the pA2 values of seven antagonists were found to be very similar on human and rat platelets. The potency ranking w …
Role of thromboxane in control of arterial pressure and renal function in young spontaneously hypertensive rats.
Grone HJ, Grippo RS, Arendshorst WJ, Dunn MJ. Grone HJ, et al. Am J Physiol. 1986 Mar;250(3 Pt 2):F488-96. doi: 10.1152/ajprenal.1986.250.3.F488. Am J Physiol. 1986. PMID: 3953827
A selective inhibitor of TXA2 synthetase (UK 38485) was given acutely, with or without a TXA2 receptor antagonist (EP-092), to 6- to 8-wk-old SHR and age-matched Wistar-Kyoto rats (WKY) and chronically for 5.5 wk to 3.5-wk-old SHR. ...
A selective inhibitor of TXA2 synthetase (UK 38485) was given acutely, with or without a TXA2 receptor antagonist (EP-092), to …
Prostaglandin E receptor subtypes in smooth muscle: agonist activities of stable prostacyclin analogues.
Dong YJ, Jones RL, Wilson NH. Dong YJ, et al. Br J Pharmacol. 1986 Jan;87(1):97-107. doi: 10.1111/j.1476-5381.1986.tb10161.x. Br J Pharmacol. 1986. PMID: 2420404 Free PMC article.
When necessary thromboxane-like activity was eliminated using the thromboxane receptor antagonists EP 045 and EP 092. On the bullock iris sphincter, rat stomach fundus and guinea-pig trachea, (+/-) omega-tetranor-16-p-chlorophenoxy PGE2 (ICI 80205) and 16,16-dimethy …
When necessary thromboxane-like activity was eliminated using the thromboxane receptor antagonists EP 045 and EP 092. On the b …
Contractile effects of prostanoids on fetal rabbit ductus arteriosus.
Smith GC, McGrath JC. Smith GC, et al. J Cardiovasc Pharmacol. 1995 Jan;25(1):113-8. doi: 10.1097/00005344-199501000-00018. J Cardiovasc Pharmacol. 1995. PMID: 7723339
The response to U46619 was shifted to the right by the thromboxane receptor antagonist EP 092. In 10 nM PGE2, U46619, sulprostone, and GR63799X elicited similar contractile responses, whereas PGF2 alpha had no effect....
The response to U46619 was shifted to the right by the thromboxane receptor antagonist EP 092. In 10 nM PGE2, U46619, sulprost …
Effect of the thromboxane receptor antagonist EP 092 on endotoxin shock in the sheep.
Armstrong RA, Jones RL, Wilson NH. Armstrong RA, et al. Prostaglandins. 1985 May;29(5):703-13. doi: 10.1016/0090-6980(85)90131-5. Prostaglandins. 1985. PMID: 2989977
The thromboxane receptor antagonist EP 092 inhibits the acute pulmonary vascular response to E. coli endotoxin in the anaesthetized, closed-chest sheep. ...Isolated strips of lobar pulmonary veins but not lobar arteries are contracted by low concentrations of 11,9-e …
The thromboxane receptor antagonist EP 092 inhibits the acute pulmonary vascular response to E. coli endotoxin in the anaesthe …
Characterization of the prostanoid receptors mediating constriction and relaxation of human isolated uterine artery.
Baxter GS, Clayton JK, Coleman RA, Marshall K, Sangha R, Senior J. Baxter GS, et al. Br J Pharmacol. 1995 Sep;116(1):1692-6. doi: 10.1111/j.1476-5381.1995.tb16393.x. Br J Pharmacol. 1995. PMID: 8564239 Free PMC article.
Constrictor responses induced by all agonists tested were reduced or abolished by the TP-receptor blocking drugs, GR 32191 and EP 092. pA2 estimates for both antagonists versus U-46619 were 8.50, values which are consistent with their affinities at TP-receptors. 4. …
Constrictor responses induced by all agonists tested were reduced or abolished by the TP-receptor blocking drugs, GR 32191 and EP …
Contractile effects of TxA2 and endoperoxide analogues on cultured rat glomerular mesangial cells.
Mené P, Dunn MJ. Mené P, et al. Am J Physiol. 1986 Dec;251(6 Pt 2):F1029-35. doi: 10.1152/ajprenal.1986.251.6.F1029. Am J Physiol. 1986. PMID: 3538903
TxA2 contracted 30.1% of the cells, with a maximum CSA decrease of 20.5 +/- 2.4%. The TxA2-receptor antagonists EP 092 (EP) and SQ 27,427 (SQ) significantly (P less than 0.05) reduced the number of cells contracting in response to U-44069 (+EP 7.3%, +SQ 10.8%) or U- …
TxA2 contracted 30.1% of the cells, with a maximum CSA decrease of 20.5 +/- 2.4%. The TxA2-receptor antagonists EP 092 (EP) an …
27 results