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Did you mean diolein (524 results)?
Dioclein, a new nitric oxide- and endothelium-dependent vasodilator flavonoid.
Lemos VS, Freitas MR, Muller B, Lino YD, Queiroga CE, Côrtes SF. Lemos VS, et al. Eur J Pharmacol. 1999 Dec 10;386(1):41-6. doi: 10.1016/s0014-2999(99)00747-5. Eur J Pharmacol. 1999. PMID: 10611462
In the present work, the vasorelaxant effect of dioclein, a new flavonoid isolated from Dioclea grandiflora (Leguminoseae), was investigated in the rat aorta. ...Neither indomethacin (10 microM), an inhibitor of cyclo-oxygenase, nor atropine (1 microM), an antagonist of mu …
In the present work, the vasorelaxant effect of dioclein, a new flavonoid isolated from Dioclea grandiflora (Leguminoseae), was inves …
The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue.
Gonçalves RL, Lugnier C, Keravis T, Lopes MJ, Fantini FA, Schmitt M, Cortes SF, Lemos VS. Gonçalves RL, et al. Eur J Pharmacol. 2009 Oct 12;620(1-3):78-83. doi: 10.1016/j.ejphar.2009.08.008. Epub 2009 Aug 15. Eur J Pharmacol. 2009. PMID: 19686719 Free article.
Our data show that dioclein is a potent calmodulin-independent selective inhibitor of PDE1 and that inhibition of PDE1 is involved in the PKG-mediated vasorelaxant effect of dioclein in human saphenous vein. Furthermore, dioclein may represent a new archetype …
Our data show that dioclein is a potent calmodulin-independent selective inhibitor of PDE1 and that inhibition of PDE1 is involved in …
Endothelium-independent vasorelaxant effect of dioclein, a new flavonoid isolated from Dioclea grandiflora, in the rat aorta.
Trigueiro F, Cortes SF, Almeida RN, Lemos VS. Trigueiro F, et al. J Pharm Pharmacol. 2000 Nov;52(11):1431-4. doi: 10.1211/0022357001777441. J Pharm Pharmacol. 2000. PMID: 11186253
We have investigated the endothelium-independent vasorelaxant effect of the new flavonoid dioclein (5,2',5'-trihydroxy-6-7-dimethoxyflavanone) in the rat aorta. ...In the absence of extracellular calcium, dioclein reduced the contraction induced by noradrenaline (ma …
We have investigated the endothelium-independent vasorelaxant effect of the new flavonoid dioclein (5,2',5'-trihydroxy-6-7-dimethoxyf …
The flavonoid dioclein reduces the production of pro-inflammatory mediators in vitro by inhibiting PDE4 activity and scavenging reactive oxygen species.
Guabiraba R, Campanha-Rodrigues AL, Souza AL, Santiago HC, Lugnier C, Alvarez-Leite J, Lemos VS, Teixeira MM. Guabiraba R, et al. Eur J Pharmacol. 2010 May 10;633(1-3):85-92. doi: 10.1016/j.ejphar.2010.01.021. Epub 2010 Feb 10. Eur J Pharmacol. 2010. PMID: 20152831 Free article.
Dioclein was efficient in reducing the production of cytokines, chemokines and NO in a concentration-dependent manner (from 5 to 50muM). Dioclein was more effective than BHT and rolipram, while having similar inhibitory effects to the combination of BHT plus rolipra …
Dioclein was efficient in reducing the production of cytokines, chemokines and NO in a concentration-dependent manner (from 5 to 50mu …
Complexation with beta-cyclodextrin confers oral activity on the flavonoid dioclein.
Rezende BA, Cortes SF, De Sousa FB, Lula IS, Schmitt M, Sinisterra RD, Lemos VS. Rezende BA, et al. Int J Pharm. 2009 Feb 9;367(1-2):133-9. doi: 10.1016/j.ijpharm.2008.09.046. Epub 2008 Oct 7. Int J Pharm. 2009. PMID: 18955122
The inclusion of dioclein in beta-CD increased the water solubility 44% compared to free dioclein. ...The in vitro vasodilator effect of dioclein was unchanged by its inclusion in beta-CD showing that the IC does not change the interaction between dioclein …
The inclusion of dioclein in beta-CD increased the water solubility 44% compared to free dioclein. ...The in vitro vasodilator …
Antiarrhythmogenic and antioxidant effect of the flavonoid dioclein in a model of cardiac ischemia/reperfusion.
Vianna HR, Cortes SF, Ferreira AJ, Capettini LS, Schmitt M, Almeida AP, Massensini AR, Lemos VS. Vianna HR, et al. Planta Med. 2006 Mar;72(4):300-3. doi: 10.1055/s-2005-916218. Planta Med. 2006. PMID: 16557469
Low concentrations of dioclein (30-300 nM) induced a reduction of arrhythmias observed during the reperfusion period. Dioclein also preserved the diastolic tension after reperfusion without affecting the systolic tension. ...
Low concentrations of dioclein (30-300 nM) induced a reduction of arrhythmias observed during the reperfusion period. Dioclein …
Pharmacological evidence for the activation of potassium channels as the mechanism involved in the hypotensive and vasorelaxant effect of dioclein in rat small resistance arteries.
Côrtes SF, Rezende BA, Corriu C, Medeiros IA, Teixeira MM, Lopes MJ, Lemos VS. Côrtes SF, et al. Br J Pharmacol. 2001 Jul;133(6):849-58. doi: 10.1038/sj.bjp.0704147. Br J Pharmacol. 2001. PMID: 11454658 Free PMC article.
Subsequent doses of dioclein (5 and 10 mg kg(-1)) produced hypotensive responses with no significant change in heart rate. ...In conclusion dioclein lowered arterial pressure probably through a decrease in peripheral vascular resistance. ...
Subsequent doses of dioclein (5 and 10 mg kg(-1)) produced hypotensive responses with no significant change in heart rate. ...In conc …
Increase on the coronary flow induced by dioclein in isolated rat heart.
Almeida AP, Côrtes SF, Ferreira AJ, Lemos VS. Almeida AP, et al. Life Sci. 2002 Jan 25;70(10):1121-8. doi: 10.1016/s0024-3205(01)01470-9. Life Sci. 2002. PMID: 11848296
In the present work the effect of dioclein, a new flavonoid from Dioclea grandiflora, was investigated in rat hearts. ...Besides, the effect of dioclein measured as the area-under-the-curve was approximately 4.5-folds higher than that observed with NPS. ...
In the present work the effect of dioclein, a new flavonoid from Dioclea grandiflora, was investigated in rat hearts. ...Besides, the …
Analgesic effect of Dioclea grandiflora constituents in rodents.
Batista JS, Almeida RN, Bhattacharyya J. Batista JS, et al. J Ethnopharmacol. 1995 Mar;45(3):207-10. doi: 10.1016/0378-8741(94)01217-n. J Ethnopharmacol. 1995. PMID: 7623485
An aqueous fraction and dioclein (5,2',5'-trihydroxy-6,7-dimethoxyflavanone) obtained from the ethanolic extract of the Dioclea grandiflora were tested for their analgesic effect in mice and rats employing acetic-induced writhing and tail flick tests, respectively. When ad …
An aqueous fraction and dioclein (5,2',5'-trihydroxy-6,7-dimethoxyflavanone) obtained from the ethanolic extract of the Dioclea grand …
Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels.
Calderone V, Chericoni S, Martinelli C, Testai L, Nardi A, Morelli I, Breschi MC, Martinotti E. Calderone V, et al. Naunyn Schmiedebergs Arch Pharmacol. 2004 Oct;370(4):290-8. doi: 10.1007/s00210-004-0964-z. Epub 2004 Sep 17. Naunyn Schmiedebergs Arch Pharmacol. 2004. PMID: 15378228
Among them, the activation of vascular potassium channels has been indicated as a possible pathway, accounting, at least in part, for the vasodilatory action of some flavonoid derivatives, such as apigenin and dioclein. Therefore, this work aims at evaluating, on in vitro …
Among them, the activation of vascular potassium channels has been indicated as a possible pathway, accounting, at least in part, for the va …
11 results