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Randomized, double-blind, noninferiority study of diclofenac diethylamine 2.32% gel applied twice daily versus diclofenac diethylamine 1.16% gel applied four times daily in patients with acute ankle sprain.
Yin F, Ma J, Xiao H, Ao R, Zhang F, Li W, Wang W, Zeng P, Lu T, Revel FB, Araga M, Patel S, Moreira S, Zhang J, Zhang W. Yin F, et al. BMC Musculoskelet Disord. 2022 Dec 24;23(1):1125. doi: 10.1186/s12891-022-06077-z. BMC Musculoskelet Disord. 2022. PMID: 36566202 Free PMC article. Clinical Trial.
BACKGROUND: Diclofenac diethylamine (DDEA) gel has demonstrated efficacy for treatment of ankle sprains in both the 1.16% four-times-daily (QID) and 2.32% twice-daily (BID) formulations. ...
BACKGROUND: Diclofenac diethylamine (DDEA) gel has demonstrated efficacy for treatment of ankle sprains in both the 1.16% four …
Diclofenac diethylamine nanosystems-loaded bigels for topical delivery: development, rheological characterization, and release studies.
Hamed R, Mahmoud NN, Alnadi SH, Alkilani AZ, Hussein G. Hamed R, et al. Drug Dev Ind Pharm. 2020 Oct;46(10):1705-1715. doi: 10.1080/03639045.2020.1820038. Epub 2020 Sep 18. Drug Dev Ind Pharm. 2020. PMID: 32892653
The objective of this study was to develop novel topical drug delivery systems of the nonsteroidal anti-inflammatory drug diclofenac diethylamine (DDEA). Toward this objective, DDEA was loaded into two nanosystems, the oil in water (O/W) nanoemulsion (DDEA-NE) and t …
The objective of this study was to develop novel topical drug delivery systems of the nonsteroidal anti-inflammatory drug diclofenac …
Hydrogel increases diclofenac skin permeation and absorption.
Haltner-Ukomadu E, Sacha M, Richter A, Hussein K. Haltner-Ukomadu E, et al. Biopharm Drug Dispos. 2019 Jul;40(7):217-224. doi: 10.1002/bdd.2194. Epub 2019 Jul 18. Biopharm Drug Dispos. 2019. PMID: 31242332 Free PMC article.
METHODS: The formulations tested were hydrogel 1% diclofenac sodium and two emulsion gels (1.16%/2.32% diclofenac diethylamine, equivalent to 1%/2% diclofenac sodium). Human abdominal skin obtained during unrelated surgical procedures was stored at -20 C until use. …
METHODS: The formulations tested were hydrogel 1% diclofenac sodium and two emulsion gels (1.16%/2.32% diclofenac diethylamine …
Controlled Release Gel Encompassing Curcumin Microspheres and Diclofenac Diethylamine for Feat Against Arthritis Inflammation.
Singh P, Dabre S. Singh P, et al. Curr Rheumatol Rev. 2020;16(2):110-119. doi: 10.2174/1573397115666191105142827. Curr Rheumatol Rev. 2020. PMID: 31738154
OBJECTIVE: This research aims at formulation of controlled release dosage form containing curcumin microspheres and diclofenac diethylamine and then incorporating it into gel formulation for treatment of inflammation associated with rheumatoid arthritis. ...RESULTS: …
OBJECTIVE: This research aims at formulation of controlled release dosage form containing curcumin microspheres and diclofenac die …
Effect of rubbing on the in vitro skin permeation of diclofenac-diethylamine 1.16% gel.
Hasler-Nguyen N, Fotopoulos G. Hasler-Nguyen N, et al. BMC Res Notes. 2012 Jun 21;5:321. doi: 10.1186/1756-0500-5-321. BMC Res Notes. 2012. PMID: 22720797 Free PMC article.
Skin electrical resistance was also recorded. RESULTS: Application of diclofenac-diethylamine 1.16% gel with rubbing resulted to a 5-fold higher flux of diclofenac through the skin than when applied without rubbing at 8 h (P = 0.04). Skin rubbing for 45 s decreased …
Skin electrical resistance was also recorded. RESULTS: Application of diclofenac-diethylamine 1.16% gel with rubbing resulted …
A randomized, parallel control and multicenter clinical trial of evidence-based traditional Chinese medicine massage treatment VS External Diclofenac Diethylamine Emulgel for the treatment of knee osteoarthritis.
Wen-Yue W, Ying-Peng X, Quan-Mao D, Li-Min X, De-Zhi W, Yang B, Li-Su W, Yu-Bin L, Zhi-Jun N, Yan-Xu M, Wu-Zhong C, Li-Qun B, Yang L, Li-Kun J. Wen-Yue W, et al. Trials. 2022 Jul 8;23(1):555. doi: 10.1186/s13063-022-06388-5. Trials. 2022. PMID: 35804406 Free PMC article. Clinical Trial.
The purposes of this study will be to provide clinicians a complementary and alternative therapy for patients and to evaluate the efficacy and safety of evidence-based traditional Chinese medicine massage treatment of KOA compared to External Diclofenac Diethylamine …
The purposes of this study will be to provide clinicians a complementary and alternative therapy for patients and to evaluate the efficacy a …
Penetration of topical diclofenac into synovial tissue and fluid of osteoarthritic knees: a multicenter, randomized, placebo-controlled, pharmacokinetic study.
Seefried L, Blyth M, Maheshwari R, McDonnell SM, Frappin G, Hagen M, Maybaum N, Moreira S, Pandit H. Seefried L, et al. Ther Adv Musculoskelet Dis. 2020 Aug 29;12:1759720X20943088. doi: 10.1177/1759720X20943088. eCollection 2020. Ther Adv Musculoskelet Dis. 2020. PMID: 32922524 Free PMC article.
METHODS: In this phase I, double-blind, multicenter study, patients scheduled for arthroplasty for end-stage knee osteoarthritis were randomly assigned 2:1 to 4 g diclofenac diethylamine 2.32% w/w gel (92.8 mg diclofenac diethylamine, equivalent to 74. …
METHODS: In this phase I, double-blind, multicenter study, patients scheduled for arthroplasty for end-stage knee osteoarthritis were random …
Nanoemulsion-based gel formulation of diclofenac diethylamine: design, optimization, rheological behavior and in vitro diffusion studies.
Hamed R, Basil M, AlBaraghthi T, Sunoqrot S, Tarawneh O. Hamed R, et al. Pharm Dev Technol. 2016 Dec;21(8):980-989. doi: 10.3109/10837450.2015.1086372. Epub 2015 Sep 15. Pharm Dev Technol. 2016. PMID: 26369621
Chronic oral administration of the non-steroidal anti-inflammatory drug, diclofenac diethylamine (DDEA), is often associated with gastrointestinal ulcers and bleeding. ...
Chronic oral administration of the non-steroidal anti-inflammatory drug, diclofenac diethylamine (DDEA), is often associated w …
Reduction of residual topical diclofenac in waste water by a wiping procedure before hand washing.
Bielfeldt S, Urquhart D, Brandt M, Hennighausen N, Bazzanella R. Bielfeldt S, et al. Chemosphere. 2022 Apr;292:133350. doi: 10.1016/j.chemosphere.2021.133350. Epub 2021 Dec 18. Chemosphere. 2022. PMID: 34933024 Free article.
The aim of this study quantifies the amount of diclofenac present in rinse water after the application of a topical pain gel containing 23.2 mg/g diclofenac diethylamine, and subsequent washing of the hands. A comparison of two different hand washing techniques was …
The aim of this study quantifies the amount of diclofenac present in rinse water after the application of a topical pain gel containing 23.2 …
68 results