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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1948 1
1949 2
1950 1
1951 2
1952 4
1953 3
1954 2
1955 5
1956 2
1957 5
1958 4
1959 3
1960 3
1961 5
1962 7
1963 10
1964 19
1965 13
1966 16
1967 6
1968 13
1969 10
1970 13
1971 21
1972 41
1973 50
1974 44
1975 50
1976 32
1977 35
1978 38
1979 31
1980 20
1981 28
1982 39
1983 32
1984 39
1985 40
1986 24
1987 31
1988 29
1989 35
1990 31
1991 31
1992 47
1993 45
1994 32
1995 59
1996 53
1997 54
1998 69
1999 78
2000 90
2001 111
2002 98
2003 94
2004 122
2005 128
2006 147
2007 124
2008 153
2009 185
2010 176
2011 251
2012 257
2013 256
2014 262
2015 317
2016 284
2017 282
2018 266
2019 298
2020 294
2021 280
2022 268
2023 225
2024 79

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5,733 results

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Page 1
METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle.
Zhang X, Meng W, Feng J, Gao X, Qin C, Feng P, Huang Y, Gao SJ. Zhang X, et al. Cell Death Dis. 2023 Sep 6;14(9):591. doi: 10.1038/s41419-023-06121-3. Cell Death Dis. 2023. PMID: 37673880 Free PMC article.
As a rate-limiting enzyme in the methionine-S-adenosylmethionine (SAM) cycle, MAT2A catalyzes the conversion of L-methionine to SAM required for the transmethylation of protein, DNA and RNA, transamination of polyamines, and transsulfuration of cystathionine. Consequently, …
As a rate-limiting enzyme in the methionine-S-adenosylmethionine (SAM) cycle, MAT2A catalyzes the conversion of L-methionine to SAM required …
Hydrogen sulfide in health and diseases: cross talk with noncoding RNAs.
Lu QB, Ding Y, Fu X, Sun HJ, Zhang JR. Lu QB, et al. Am J Physiol Cell Physiol. 2023 Apr 1;324(4):C856-C877. doi: 10.1152/ajpcell.00507.2022. Epub 2023 Mar 6. Am J Physiol Cell Physiol. 2023. PMID: 36878842 Free article. Review.
However, this gasotransmitter is also endogenously generated by the actions of cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST) in mammalian systems, thus belonging to the family of gasotransmitters …
However, this gasotransmitter is also endogenously generated by the actions of cystathionine-beta-synthase (CBS), cystathionine …
Multiomic screening of invasive GBM cells reveals targetable transsulfuration pathway alterations.
Garcia JH, Akins EA, Jain S, Wolf KJ, Zhang J, Choudhary N, Lad M, Shukla P, Rios J, Seo K, Gill SA, Carson WH, Carette LR, Zheng AC, Raleigh DR, Kumar S, Aghi MK. Garcia JH, et al. J Clin Invest. 2023 Nov 16;134(3):e170397. doi: 10.1172/JCI170397. J Clin Invest. 2023. PMID: 37971886 Free PMC article.
Metabolomics and lipidomics revealed elevations in the redox buffers cystathionine, hexosylceramides, and glucosyl ceramides in the invasive front of both hydrogel-cultured tumors and patient site-directed biopsies, with immunofluorescence indicating elevated reactive oxyg …
Metabolomics and lipidomics revealed elevations in the redox buffers cystathionine, hexosylceramides, and glucosyl ceramides in the i …
Chemistry of Hydrogen Sulfide-Pathological and Physiological Functions in Mammalian Cells.
Andrés CMC, Pérez de la Lastra JM, Andrés Juan C, Plou FJ, Pérez-Lebeña E. Andrés CMC, et al. Cells. 2023 Nov 22;12(23):2684. doi: 10.3390/cells12232684. Cells. 2023. PMID: 38067112 Free PMC article. Review.
H(2)S is synthesized by enzymatic processes involving cysteine and several enzymes, including cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), cysteine aminotransferase (CAT), 3-mercaptopyruvate sulfurtransferase (3MST) and D-amino acid oxidase (D …
H(2)S is synthesized by enzymatic processes involving cysteine and several enzymes, including cystathionine-beta-synthase (CBS), c …
Cystathionine-gamma-lyase attenuates inflammatory response and pain of osteoarthritis.
Wei K, Shu Z, Pu H, Xu H, Li S, Xiao J, Zhu Y, Ma T. Wei K, et al. Int Immunopharmacol. 2023 Jul;120:110289. doi: 10.1016/j.intimp.2023.110289. Epub 2023 May 12. Int Immunopharmacol. 2023. PMID: 37182456 Free article.
The chronic articular disease osteoarthritis (OA) is characterized by osteophyte generation, subchondral bone remodeling, and cartilage deterioration. Low levels of H2S catalyzed by cystathionine-gamma-lyase (CSE) encoded by Cthhas neuroprotective, cardioprotective, anti-a …
The chronic articular disease osteoarthritis (OA) is characterized by osteophyte generation, subchondral bone remodeling, and cartilage dete …
L-cysteine/cystathionine-beta-synthase-induced relaxation in mouse aorta involves a L-serine/sphingosine-1-phosphate/NO pathway.
Mitidieri E, Gurgone D, Caiazzo E, Tramontano T, Cicala C, Sorrentino R, d'Emmanuele di Villa Bianca R. Mitidieri E, et al. Br J Pharmacol. 2020 Feb;177(4):734-744. doi: 10.1111/bph.14654. Epub 2019 Apr 22. Br J Pharmacol. 2020. PMID: 30835815 Free PMC article.
BACKGROUND AND PURPOSE: Among the three enzymes involved in the transsulfuration pathway, only cystathionine beta-synthase (CBS) converts L-cysteine into L-serine and H(2) S. ...
BACKGROUND AND PURPOSE: Among the three enzymes involved in the transsulfuration pathway, only cystathionine beta-synthase (CBS) conv …
Neurochemical Differences between 1p/19q Codeleted and Noncodeleted IDH-mutant Gliomas by in Vivo MR Spectroscopy.
Branzoli F, Liserre R, Deelchand DK, Poliani PL, Bielle F, Nichelli L, Sanson M, Lehéricy S, Marjańska M. Branzoli F, et al. Radiology. 2023 Sep;308(3):e223255. doi: 10.1148/radiol.223255. Radiology. 2023. PMID: 37668523
Conclusion Higher cystathionine levels were detected in IDH1-mutant 1p/19q codeleted gliomas than in their noncodeleted counterparts with use of a PRESS sequence optimized for 2HG detection. Of 19 metabolites quantified, only cystathionine showed evidence of a diffe …
Conclusion Higher cystathionine levels were detected in IDH1-mutant 1p/19q codeleted gliomas than in their noncodeleted counterparts …
Structural basis of the inhibition of cystathionine gamma-lyase from Toxoplasma gondii by propargylglycine and cysteine.
Fernández-Rodríguez C, Conter C, Oyenarte I, Favretto F, Quintana I, Martinez-Chantar ML, Astegno A, Martínez-Cruz LA. Fernández-Rodríguez C, et al. Protein Sci. 2023 Apr;32(4):e4619. doi: 10.1002/pro.4619. Protein Sci. 2023. PMID: 36883335 Free PMC article.
Cystathionine gamma-lyase (CGL) is a PLP-dependent enzyme that catalyzes the last step of the reverse transsulfuration route for endogenous cysteine biosynthesis. ...Interestingly, the substitution of N360 by a serine (the equivalent amino acid residue in the human enzyme) …
Cystathionine gamma-lyase (CGL) is a PLP-dependent enzyme that catalyzes the last step of the reverse transsulfuration route for endo …
5,733 results