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Metabolism and disposition of cyproheptadine and desmethylcyproheptadine in pregnant and fetal rats.
Chow SA, Fischer LJ. Chow SA, et al. Drug Metab Dispos. 1987 Nov-Dec;15(6):740-8. Drug Metab Dispos. 1987. PMID: 2893697
In separate experiments designed to examine the metabolic capability of the fetus (day 20 of gestation), it was found that fetally administered CPH was not demethylated and, instead, epoxidated to form cyproheptadine-10,11-epoxide (CPH-epoxide). Admini …
In separate experiments designed to examine the metabolic capability of the fetus (day 20 of gestation), it was found that fetally administe …
Postnatal changes in the insulin-depleting action and disposition of cyproheptadine in rats.
Chow SA, Fischer LJ. Chow SA, et al. Dev Pharmacol Ther. 1991;16(3):150-63. Dev Pharmacol Ther. 1991. PMID: 1914789
In separate experiments, the concentrations of CPH and its active metabolites, desmethylcyproheptadine (DMCPH), desmethylcyproheptadine-10,11-epoxide (DMCPH-epoxide) and cyproheptadine-10,11-epoxide (CPH-epoxide), were measured in the pancreas, liver a …
In separate experiments, the concentrations of CPH and its active metabolites, desmethylcyproheptadine (DMCPH), desmethylcyproheptadine-10,1 …
Fungal transformations of antihistamines: metabolism of cyproheptadine hydrochloride by Cunninghamella elegans.
Zhang D, Hansen EB Jr, Deck J, Heinze TM, Henderson A, Korfmacher WA, Cerniglia CE. Zhang D, et al. Xenobiotica. 1997 Mar;27(3):301-15. doi: 10.1080/004982597240622. Xenobiotica. 1997. PMID: 9141237
Other metabolites identified were 1- and 3-hydroxycyproheptadine, cyproheptadine 10,11-epoxide, N-desmethylcyproheptadine, N-desmethyl-2-hydroxycyproheptadine, cyproheptadine N-oxide, and 2-hydroxycyproheptadine N-oxide. Although a minor fungal metabol …
Other metabolites identified were 1- and 3-hydroxycyproheptadine, cyproheptadine 10,11-epoxide, N-desmethylcypro …