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Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro.
Becker G, Kawan A, Gutzeit D, Worek F, Szinicz L. Becker G, et al. Arch Toxicol. 2007 Jun;81(6):415-20. doi: 10.1007/s00204-006-0168-z. Epub 2006 Dec 7. Arch Toxicol. 2007. PMID: 17151865
The direct reaction of seven pyridinium oximes with the organophosphorus compounds (OPCs) crotylsarin, cyclosarin, and VX was studied by spectrophotometry. This method allows to quantify different parameters: (a) the half-life times (t (1/2)) of the oxime-OPC reactions on …
The direct reaction of seven pyridinium oximes with the organophosphorus compounds (OPCs) crotylsarin, cyclosarin, and VX was studied …
Comparison of the therapeutic effects and pharmacokinetics of HI-6, HLö-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats.
van Helden HP, van der Wiel HJ, Zijlstra JJ, Melchers BP, Busker RW. van Helden HP, et al. Arch Toxicol. 1994;68(4):224-30. doi: 10.1007/s002040050061. Arch Toxicol. 1994. PMID: 8067894
To test this anaesthetized, atropinized and artificially ventilated rats (n = 8 or 16) were poisoned with a three times LD50 dose of the potent AChE-inhibitor crotylsarin (CRS, i.v.). CRS-inhibited rat AChE dealkylates instantaneously, thereby excluding AChE reactivation b …
To test this anaesthetized, atropinized and artificially ventilated rats (n = 8 or 16) were poisoned with a three times LD50 dose of the pot …
Central respiratory effects on motor nerve activities after organophosphate exposure in a working heart brainstem preparation of the rat.
Klein-Rodewald T, Seeger T, Dutschmann M, Worek F, Mörschel M. Klein-Rodewald T, et al. Toxicol Lett. 2011 Sep 25;206(1):94-9. doi: 10.1016/j.toxlet.2011.07.005. Epub 2011 Jul 8. Toxicol Lett. 2011. PMID: 21767620
The impact of organophosphorus compound (OP) intoxication on the activity of central respiratory circuitry, causing acetylcholinesterase (AChE) inhibition and accumulation of acetylcholine in the respiratory brainstem circuits, is not understood. We investigated the central effec …
The impact of organophosphorus compound (OP) intoxication on the activity of central respiratory circuitry, causing acetylcholinesterase (AC …
Organophosphate poisoning: a method to test therapeutic effects of oximes other than acetylcholinesterase reactivation in the rat.
Busker RW, Zijlstra JJ, van der Wiel HJ, Melchers BP, van Helden HP. Busker RW, et al. Toxicology. 1991;69(3):331-44. doi: 10.1016/0300-483x(91)90191-3. Toxicology. 1991. PMID: 1658986
A method was developed to study exclusively those therapeutic effects of oximes that are not related to reactivation of organophosphate-inhibited acetylcholinesterase (AChE). The model uses the organophosphorus compound crotylsarin (CRS), which proved to be a potent, irrev …
A method was developed to study exclusively those therapeutic effects of oximes that are not related to reactivation of organophosphate-inhi …