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Phylogeny Predicts the Quantity of Antimalarial Alkaloids within the Iconic Yellow Cinchona Bark (Rubiaceae: Cinchona calisaya).
Maldonado C, Barnes CJ, Cornett C, Holmfred E, Hansen SH, Persson C, Antonelli A, Rønsted N. Maldonado C, et al. Front Plant Sci. 2017 Mar 22;8:391. doi: 10.3389/fpls.2017.00391. eCollection 2017. Front Plant Sci. 2017. PMID: 28382048 Free PMC article.
Understanding which factors determine chemical diversity has the potential to shed light on plant defenses against herbivores and diseases and accelerate drug discovery. For centuries, Cinchona alkaloids were the primary treatment of malaria. Using Cinchona calis …
Understanding which factors determine chemical diversity has the potential to shed light on plant defenses against herbivores and diseases a …
Cinchonine: A Versatile Pharmacological Agent Derived from Natural Cinchona Alkaloids.
Parveen S, Maurya N, Meena A, Luqman S. Parveen S, et al. Curr Top Med Chem. 2023 Nov 27. doi: 10.2174/0115680266270796231109171808. Online ahead of print. Curr Top Med Chem. 2023. PMID: 38031797
BACKGROUND: Cinchonine is one of the Cinchona alkaloids that is commercially extracted from the Peruvian bark of Cinchona officinalis L. ...It is also obtained in much lower quantities from other species of Cinchona, such as Cinchona calisaya, …
BACKGROUND: Cinchonine is one of the Cinchona alkaloids that is commercially extracted from the Peruvian bark of Cinchona offi …
Reproductive toxicology and clastogenic evaluation in mice of a phytotherapeutic formulation obtained from Cinchona calisaya Weddel (Rubiaceae) used in Brazilian folk medicine as female fertility stimulant.
do Amaral VL, Frajbat M, Petreanu M, Zermiani T, de Freitas RA, Maistro EL, Niero R, Bresolin TM, Filho VC, de Andrade SF. do Amaral VL, et al. J Ethnopharmacol. 2014 Sep 29;155(3):1508-12. doi: 10.1016/j.jep.2014.07.038. Epub 2014 Jul 25. J Ethnopharmacol. 2014. PMID: 25068580
ETHNOPHARMACOLOGICAL RELEVANCE: In Brazil, a phytotherapeutic preparation produced from a standardized tincture of Cinchona calisaya Weddel such that each mL of product contains 400g of quinine, known in Portuguese as Agua Inglesa() (English water), is indicated by …
ETHNOPHARMACOLOGICAL RELEVANCE: In Brazil, a phytotherapeutic preparation produced from a standardized tincture of Cinchona calisa …
Effect of Medium pH and Light on Quinidine Production in Cinchona calisaya Wedd. Endophytic Fungi.
Rahmawati I, Rahayu G, Ratnadewi D, Achmadi S. Rahmawati I, et al. Turk J Pharm Sci. 2021 Apr 20;18(2):124-132. doi: 10.4274/tjps.galenos.2020.35761. Turk J Pharm Sci. 2021. PMID: 33900523 Free PMC article.
Quinidine is in high demand, yet its production from the bark of the quina tree (Cinchona calisaya) is limited. Quinidine production from quina tree fungal endophytes, namely Aspergillus sydowii, Diaporthe sp., Diaporthe lithicola, Fusarium oxysporum, and F. solani …
Quinidine is in high demand, yet its production from the bark of the quina tree (Cinchona calisaya) is limited. Quinidine prod …
Antimalarial activity of Cinchona-like plants used to treat fever and malaria in Brazil.
Andrade-Neto VF, Brandão MG, Stehmann JR, Oliveira LA, Krettli AU. Andrade-Neto VF, et al. J Ethnopharmacol. 2003 Aug;87(2-3):253-6. doi: 10.1016/s0378-8741(03)00141-7. J Ethnopharmacol. 2003. PMID: 12860318
For centuries, malaria was treated with the bark of Cinchona calisaya and Cinchona succirubra plants named "quinas" in Brazil, from which the quinine molecule was isolated. ...
For centuries, malaria was treated with the bark of Cinchona calisaya and Cinchona succirubra plants named "quinas" in …
Unexpectedly High Beta-Diversity of Root-Associated Fungal Communities in the Bolivian Andes.
Barnes CJ, Maldonado C, Frøslev TG, Antonelli A, Rønsted N. Barnes CJ, et al. Front Microbiol. 2016 Aug 31;7:1377. doi: 10.3389/fmicb.2016.01377. eCollection 2016. Front Microbiol. 2016. PMID: 27630629 Free PMC article.
Here we assess the genetic, taxonomic and functional diversity of root-associated fungi surrounding Cinchona calisaya trees, a typical element of the intermediate altitudes of the Bolivian Yungas. ...
Here we assess the genetic, taxonomic and functional diversity of root-associated fungi surrounding Cinchona calisaya trees, a …
[Charles Ledger and the Cinchona].
Janssens PG. Janssens PG. Verh K Acad Geneeskd Belg. 1989;51(6):535-57. Verh K Acad Geneeskd Belg. 1989. PMID: 2699686 Dutch.
The quinquina bark trade is hampered by the fact that there is a very great quantity of varieties, each having a different concentration of alkaloids in its bark. To buy the best species, Cinchona calisaya, one needs a perfect knowledge of these trees. The expertise …
The quinquina bark trade is hampered by the fact that there is a very great quantity of varieties, each having a different concentration of …
The use of an integrated molecular-, chemical- and biological-based approach for promoting the better use and conservation of medicinal species: a case study of Brazilian quinas.
Palhares RM, Drummond MG, Brasil BS, Krettli AU, Oliveira GC, Brandão MG. Palhares RM, et al. J Ethnopharmacol. 2014 Aug 8;155(1):815-22. doi: 10.1016/j.jep.2014.06.040. Epub 2014 Jun 24. J Ethnopharmacol. 2014. PMID: 24971797
ETHNOPHARMACOLOGICAL RELEVANCE: Quina is a popular name originally attributed to Cinchona pubescens Vahl (=Cinchona succirubra) and Cinchona. calisaya Wedd., species native from Peru that have the antimalarial alkaloid quinine. ...
ETHNOPHARMACOLOGICAL RELEVANCE: Quina is a popular name originally attributed to Cinchona pubescens Vahl (=Cinchona succirubra …