Investigating Derivatives of Tanshinone IIA Sulfonate Sodium and Chloroxine for Their Inhibition Activities against the SARS-CoV-2 Papain-like Protease.
Chen X, Chen K, Zhang Z, Wei P, Zhang L, Xu Y, Lun Q, Ma Y, Wu F, Zhang Y, Wang Y, Zhao J, Zhou Y, Zhan J, Xu W.
Chen X, et al.
ACS Omega. 2022 Dec 12;7(51):48416-48426. doi: 10.1021/acsomega.2c06675. eCollection 2022 Dec 27.
ACS Omega. 2022.
PMID: 36591160
Free PMC article.
Here, we investigated the structure-activity relationships of the series of derivatives of tanshinone IIA sulfonate sodium (TSS) and chloroxine based on biochemical analysis and molecular dynamics simulation. We found that compound 7, a derivative of chloroxine, can …
Here, we investigated the structure-activity relationships of the series of derivatives of tanshinone IIA sulfonate sodium (TSS) and chlo …