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Clinical pharmacokinetics of the angiotensin converting enzyme inhibitors. A review.
Kubo SH, Cody RJ. Kubo SH, et al. Clin Pharmacokinet. 1985 Sep-Oct;10(5):377-91. doi: 10.2165/00003088-198510050-00001. Clin Pharmacokinet. 1985. PMID: 2994938 Review.
Once absorbed, captopril is extensively metabolised to several forms, including a disulphide dimer of captopril, a captopril-cysteine disulphide, and other mixed disulphides with endogenous thiol compounds. ...
Once absorbed, captopril is extensively metabolised to several forms, including a disulphide dimer of captopril, a captopril-cyste …
Drug protein conjugates--I. A study of the covalent binding of [14C]captopril to plasma proteins in the rat.
Park BK, Grabowski PS, Yeung JH, Breckenridge AM. Park BK, et al. Biochem Pharmacol. 1982 May 1;31(9):1755-60. doi: 10.1016/0006-2952(82)90680-3. Biochem Pharmacol. 1982. PMID: 7049181
After 180 min 28 +/- 3% of the radioactivity was excreted in urine, largely as [14C]captopril-cysteine mixed disulphide (67%). Thus although captopril readily forms covalent bonds with plasma proteins the resulting conjugates dissociate in vivo. ...
After 180 min 28 +/- 3% of the radioactivity was excreted in urine, largely as [14C]captopril-cysteine mixed disulphide (67%). …
Captopril scavenges hydrogen peroxide and reduces, but does not eliminate, oxidant-induced cell injury.
Andreoli SP. Andreoli SP. Am J Physiol. 1993 Jan;264(1 Pt 2):F120-7. doi: 10.1152/ajprenal.1993.264.1.F120. Am J Physiol. 1993. PMID: 8381600
We investigated whether captopril, an angiotensin-converting enzyme (ACE) inhibitor with a sulfhydryl group, enalaprilat, an ACE inhibitor without a sulfhydryl group, and cysteine, an amino acid with a sulfhydryl group but no ACE-inhibiting properties, could scavenge hydrogen per …
We investigated whether captopril, an angiotensin-converting enzyme (ACE) inhibitor with a sulfhydryl group, enalaprilat, an ACE inhibitor w …
Captopril reduces urinary cystine excretion in cystinuria.
Sloand JA, Izzo JL Jr. Sloand JA, et al. Arch Intern Med. 1987 Aug;147(8):1409-12. Arch Intern Med. 1987. PMID: 2820331
No adverse side effects were observed in either patient. Formation of the captopril-cysteine disulfide accounts for part of the reduction in cystine excretion but other mechanisms probably contribute. Because captopril-cysteine disulfide is 200 times m …
No adverse side effects were observed in either patient. Formation of the captopril-cysteine disulfide accounts for part of th …
Metabolism of protein conjugate of desacetyl-alacepril and its effect on angiotensin converting enzyme in renal hypertensive rats.
Matsumoto K, Nambu K, Fujii T, Takeyama K, Miyazaki H, Hashimoto M. Matsumoto K, et al. Arzneimittelforschung. 1986;36(1):52-4. Arzneimittelforschung. 1986. PMID: 3006711
Elimination of radioactivity of [14C]DU-1227-protein from plasma after injection seemed much slower than that reported of [14C]alacepril (1-[(S)-3-acetylthio-2-methylpropanoyl]-L-prolyl-L-phenylalanine, DU-1219) given orally. In the plasma unbound fraction, captopril and capto …
Elimination of radioactivity of [14C]DU-1227-protein from plasma after injection seemed much slower than that reported of [14C]alacepril (1- …
Electrochemical reduction of disulfides.
Kadin H. Kadin H. Methods Enzymol. 1987;143:257-64. doi: 10.1016/0076-6879(87)43049-8. Methods Enzymol. 1987. PMID: 3309555 No abstract available.
[Syntheses of [prolyl-U-14C]alacepril and its related compounds].
Kagemoto A, Nakao M, Negoro T, Sekine Y, Hashimoto M. Kagemoto A, et al. Radioisotopes. 1985 Aug;34(8):408-13. doi: 10.3769/radioisotopes.34.8_408. Radioisotopes. 1985. PMID: 3906779 Japanese.
[Prolyl-U-14C]captopril and [prolyl-U-14C]DU-1227 were prepared in high yields by hydrolysis of [prolyl-U-14C]DU-1163 and [prolyl-U-14C]alacepril, respectively. [Prolyl-U-14C]captopril-cysteine was synthesized by condensation of [prolyl-U-14C]captopril with cystine …
[Prolyl-U-14C]captopril and [prolyl-U-14C]DU-1227 were prepared in high yields by hydrolysis of [prolyl-U-14C]DU-1163 and [prolyl-U-14C]alac …