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[(Z)-broparestrol].
Rodier PN, Ceolin R, Dubois P, Fournival JL. Rodier PN, et al. Acta Crystallogr C. 1989 Sep 15;45 ( Pt 9):1455-7. doi: 10.1107/s0108270189000922. Acta Crystallogr C. 1989. PMID: 2604956 French.
The cohesion of the structure is due to van der Waals interactions. A mixture of the (Z)- and (E)-isomers (Broparestrol, INN) is used in dermatology. The (Z)-isomer exhibits some aspects of the antiestrogenic activity and other actions that may be connected to the estrogen …
The cohesion of the structure is due to van der Waals interactions. A mixture of the (Z)- and (E)-isomers (Broparestrol, INN) is used …
Ethyltriphenylethylene compounds: synthesis and estrogenic and antifertility activities; partial dissociation between these two activities.
Queval P, Falconnet B, Giraud JG, Krikorian-manoukian A, Courmarcel D, Bondiou JC, Buu-hoi NP. Queval P, et al. Chim Ther. 1969 Jan-Feb;4(1):1-8. Chim Ther. 1969. PMID: 12305430 English, French.
This cis and trans isomers of Broparestrol (1-bromo-2(4-ethylphenyl)-1,2-diphenyl ethylene) and of its 1-bromo-1(4-ethylphenyl)-2,2-diphenylethylene isomer, and of the analogous 1-nitro compounds were prepared and tested for estrogenicity by the Allen-Doisy vaginal smear t …
This cis and trans isomers of Broparestrol (1-bromo-2(4-ethylphenyl)-1,2-diphenyl ethylene) and of its 1-bromo-1(4-ethylphenyl)-2,2-d …
Interactions between prolactin and ovarian secretions during mammary tumorigenesis in the mouse.
Edery M, Goussard J, Vives C, Rudali G, Drosdowsky MA. Edery M, et al. Biomedicine. 1980 Dec;33(8):265-7. Biomedicine. 1980. PMID: 7213925
Implantation of a pituitary under the kidney leads to an increase of all these parameters as well as a high mammary tumor incidence. Simultaneous administration of the trans isomer of broparestrol (TBP) leads to a decrease of all the parameters....
Implantation of a pituitary under the kidney leads to an increase of all these parameters as well as a high mammary tumor incidence. Simulta …
Inhibition of prolactin-induced mammary cancer in C3Hf (XVII) mice with the trans isomer of bromotriphenylethylene.
Drosdowsky M, Edery M, Guggiari M, Montes-Rendon A, Rudali G, Vives C. Drosdowsky M, et al. Cancer Res. 1980 May;40(5):1674-9. Cancer Res. 1980. PMID: 6245799
Under these conditions, mammary tumors appear in 90% of the mice. If a racemic brominated triphenylethylene, i.e., broparestrol, is administered, serum and pituitary prolactin decrease rapidly (10 ng/ml and 4 micrograms/mg of tissue, respectively), and prolactin receptors …
Under these conditions, mammary tumors appear in 90% of the mice. If a racemic brominated triphenylethylene, i.e., broparestrol, is a …