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1989 1
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1993 9
1994 5
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Page 1
In vitro evaluation of BRL 42715, a novel beta-lactamase inhibitor.
Coleman K, Griffin DR, Page JW, Upshon PA. Coleman K, et al. Antimicrob Agents Chemother. 1989 Sep;33(9):1580-7. doi: 10.1128/AAC.33.9.1580. Antimicrob Agents Chemother. 1989. PMID: 2817854 Free PMC article.
The concentration of BRL 42715 needed to reduce the initial rate of hydrolysis of most beta-lactamase enzymes by 50% was less than 0.01 micrograms/ml, which was 10- to 100-fold lower than for other beta-lactamase inhibitors. These potent inhibitory activities were r …
The concentration of BRL 42715 needed to reduce the initial rate of hydrolysis of most beta-lactamase enzymes by 50% was less …
Chemical and microbiologic aspects of penems, a distinct class of beta-lactams: focus on faropenem.
Hamilton-Miller JM. Hamilton-Miller JM. Pharmacotherapy. 2003 Nov;23(11):1497-507. doi: 10.1592/phco.23.14.1497.31937. Pharmacotherapy. 2003. PMID: 14620395 Review.
The chemistry and microbiology of the representative penems MEN 10700, ritipenem, CGP 31608, sulopenem, BRL 42715, and faropenem are reviewed. Particular emphasis is placed on faropenem, which is in late clinical development....
The chemistry and microbiology of the representative penems MEN 10700, ritipenem, CGP 31608, sulopenem, BRL 42715, and faropen …
Activity of the beta-lactamase inhibitor BRL 42715 against cephalosporinases produced by Enterobacteriaceae.
Zhou XY, Kitzis MD, Acar JF, Gutmann L. Zhou XY, et al. J Antimicrob Chemother. 1993 Apr;31(4):473-80. doi: 10.1093/jac/31.4.473. J Antimicrob Chemother. 1993. PMID: 8514645
BRL 42715, a novel beta-lactamase inhibitor, was evaluated for its capacity to inhibit cephalosporinases. ...When compared in vitro to clavulanic acid, sulbactam, and tazobactam, BRL 42715 was the most efficient inhibitor of cephalosporinase....
BRL 42715, a novel beta-lactamase inhibitor, was evaluated for its capacity to inhibit cephalosporinases. ...When compared in …
Characterization of a beta-lactamase from Clostridium clostridioforme.
Appelbaum PC, Spangler SK, Pankuch GA, Philippon A, Jacobs MR, Shiman R, Goldstein EJ, Citron DM. Appelbaum PC, et al. J Antimicrob Chemother. 1994 Jan;33(1):33-40. doi: 10.1093/jac/33.1.33. J Antimicrob Chemother. 1994. PMID: 8157571
No enhancement of cephalosporin activity occurred when clavulanate was also added, but a limited degree of enhancement of penicillin activity (resulting in beta-lactam MICs higher than available NCCLS breakpoints) occurred when clavulanate, sulbactam or tazobactam was added simul …
No enhancement of cephalosporin activity occurred when clavulanate was also added, but a limited degree of enhancement of penicillin activit …
Pharmacokinetic studies and renal dehydropeptidase stability of the new beta-lactamase inhibitor BRL 42715 in animals.
Coleman K, Griffin DR, Upshon PA. Coleman K, et al. Antimicrob Agents Chemother. 1991 Sep;35(9):1748-52. doi: 10.1128/AAC.35.9.1748. Antimicrob Agents Chemother. 1991. PMID: 1952842 Free PMC article.
The binding of BRL 42715 in serum was 27 to 38% in mouse, rat, and dog sera but was somewhat higher (68 to 70%) in primate and human sera. BRL 42715 was not readily hydrolyzed by the renal dehydropeptidase enzymes of any of the five species studied....
The binding of BRL 42715 in serum was 27 to 38% in mouse, rat, and dog sera but was somewhat higher (68 to 70%) in primate and …
Simulation of human serum pharmacokinetics of cefazolin, piperacillin, and BRL 42715 in rats and efficacy against experimental intraperitoneal infections.
Woodnutt G, Berry V, Mizen L. Woodnutt G, et al. Antimicrob Agents Chemother. 1992 Jul;36(7):1427-31. doi: 10.1128/AAC.36.7.1427. Antimicrob Agents Chemother. 1992. PMID: 1510438 Free PMC article.
Studies were performed to determine the effects of BRL 42715, a potent beta-lactamase inhibitor, on the activity of cefazolin and piperacillin against experimental intraperitoneal infections caused by either Escherichia coli or Serratia marcescens in rats. ...These …
Studies were performed to determine the effects of BRL 42715, a potent beta-lactamase inhibitor, on the activity of cefazolin …
SYN-1012: a new beta-lactamase inhibitor of penem skeleton.
Phillips OA, Czajkowski DP, Spevak P, Singh MP, Hanehara-Kunugita C, Hyodo A, Micetich RG, Maiti SN. Phillips OA, et al. J Antibiot (Tokyo). 1997 Apr;50(4):350-6. doi: 10.7164/antibiotics.50.350. J Antibiot (Tokyo). 1997. PMID: 9186563 Free article.
A new beta-lactamase inhibitor, SYN-1012, with a penem skeleton was synthesized and its biological activity compared with clavulanic acid, sulbactam, tazobactam and BRL-42715. The beta-lactamase inhibitory activity of SYN-1012 was comparable to BRL-42715 …
A new beta-lactamase inhibitor, SYN-1012, with a penem skeleton was synthesized and its biological activity compared with clavulanic acid, s …
Rapid identification of metallo- and serine beta-lactamases.
Payne DJ, Cramp R, Bateson JH, Neale J, Knowles D. Payne DJ, et al. Antimicrob Agents Chemother. 1994 May;38(5):991-6. doi: 10.1128/AAC.38.5.991. Antimicrob Agents Chemother. 1994. PMID: 8067782 Free PMC article.
(i) Cell lysates were preincubated with 83 mM EDTA prior to IEF and subsequent visualization with nitrocefin, and (ii) after IEF, the gels were overlaid with either 1 mM zinc sulfate or 100 microM BRL 42715 before staining with nitrocefin. Bands of beta-lactamase ac …
(i) Cell lysates were preincubated with 83 mM EDTA prior to IEF and subsequent visualization with nitrocefin, and (ii) after IEF, the gels w …
Kinetic and physical studies of beta-lactamase inhibition by a novel penem, BRL 42715.
Farmer TH, Page JW, Payne DJ, Knowles DJ. Farmer TH, et al. Biochem J. 1994 Nov 1;303 ( Pt 3)(Pt 3):825-30. doi: 10.1042/bj3030825. Biochem J. 1994. PMID: 7980451 Free PMC article.
All the beta-lactamases were rapidly inactivated by BRL 42715, with second-order rate constants ranging from 0.17 to 6.4 microM-1.s-1. ...In all cases a mass increase of 264 Da over the native enzyme was observed, corresponding to the molecular mass of BRL …
All the beta-lactamases were rapidly inactivated by BRL 42715, with second-order rate constants ranging from 0.17 to 6.4 micro …
Susceptibilities of 540 anaerobic gram-negative bacilli to amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin.
Appelbaum PC, Spangler SK, Shiman R, Jacobs MR. Appelbaum PC, et al. Antimicrob Agents Chemother. 1992 May;36(5):1140-3. doi: 10.1128/AAC.36.5.1140. Antimicrob Agents Chemother. 1992. PMID: 1324639 Free PMC article.
Agar dilution MIC testing of amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin against 496 beta-lactamase-producing anaerobic gram-negative rods revealed MICs for 90% of the strains tested of 256.0 (amoxicillin), 2.0 (amoxici …
Agar dilution MIC testing of amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin agains …
44 results