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Year Number of Results
1991 1
1995 2
1998 2
1999 2
2001 3
2002 2
2003 2
2004 3
2008 1
2011 1
2012 2
2013 2
2014 1
2017 1
2019 1
2021 1
2023 1
2024 0

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28 results

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Page 1
Differential Coupling of Binding, ATP Hydrolysis, and Transport of Fluorescent Probes with P-Glycoprotein in Lipid Nanodiscs.
Li MJ, Nath A, Atkins WM. Li MJ, et al. Biochemistry. 2017 May 16;56(19):2506-2517. doi: 10.1021/acs.biochem.6b01245. Epub 2017 May 4. Biochemistry. 2017. PMID: 28441502 Free PMC article.
Here we monitor binding of the fluorescent probe substrates BODIPY-verapamil, BODIPY-vinblastine, and Flutax-2 at low occupancy to murine P-gp in lipid nanodiscs via fluorescence correlation spectroscopy, in variable nucleotide-bound states. ...Whereas the establish …
Here we monitor binding of the fluorescent probe substrates BODIPY-verapamil, BODIPY-vinblastine, and Flutax-2 at low occupanc …
Ivermectin excretion by isolated functionally intact brain endothelial capillaries.
Nobmann S, Bauer B, Fricker G. Nobmann S, et al. Br J Pharmacol. 2001 Feb;132(3):722-8. doi: 10.1038/sj.bjp.0703762. Br J Pharmacol. 2001. PMID: 11159725 Free PMC article.
Conversely, unlabelled Ivermectin reduced the p-glycoprotein (Pgp)-mediated secretion of a fluorescent derivative of Verapamil, (BODIPY-Verapamil). 4. BODIPY-Ivermectin secretion was not affected in the presence of Leucotriene C(4) (LTC(4)), a potent inhibitor of mu …
Conversely, unlabelled Ivermectin reduced the p-glycoprotein (Pgp)-mediated secretion of a fluorescent derivative of Verapamil, (BODIPY …
Second-site suppressor mutations reveal connection between the drug-binding pocket and nucleotide-binding domain 1 of human P-glycoprotein (ABCB1).
Murakami M, Sajid A, Lusvarghi S, Durell SR, Abel B, Vahedi S, Golin J, Ambudkar SV. Murakami M, et al. Drug Resist Updat. 2023 Nov;71:101009. doi: 10.1016/j.drup.2023.101009. Epub 2023 Sep 27. Drug Resist Updat. 2023. PMID: 37797431
Although both the mutants were expressed at normal levels at the cell surface, the 6Y mutant failed to transport all the tested substrates except Bodipy-verapamil, whereas the 9Y mutant effluxed all tested substrates in a manner very similar to that of the wild-type …
Although both the mutants were expressed at normal levels at the cell surface, the 6Y mutant failed to transport all the tested substrates e …
ABCB1 Does Not Require the Side-Chain Hydrogen-Bond Donors Gln347, Gln725, Gln990 to Confer Cellular Resistance to the Anticancer Drug Taxol.
Sasitharan K, Iqbal HA, Bifsa F, Olszewska A, Linton KJ. Sasitharan K, et al. Int J Mol Sci. 2021 Aug 9;22(16):8561. doi: 10.3390/ijms22168561. Int J Mol Sci. 2021. PMID: 34445264 Free PMC article.
Flow cytometric transport assays show that Q347A and Q990A act synergistically to reduce transport of Calcein-AM, BODIPY-verapamil, and OREGON GREEN-taxol bisacetate but the magnitude of the effect was dependent on the test drug and no combination of mutations compl …
Flow cytometric transport assays show that Q347A and Q990A act synergistically to reduce transport of Calcein-AM, BODIPY-verapamil …
Major age-related changes of mouse hematopoietic stem/progenitor cells.
Kim M, Moon HB, Spangrude GJ. Kim M, et al. Ann N Y Acad Sci. 2003 May;996:195-208. doi: 10.1111/j.1749-6632.2003.tb03247.x. Ann N Y Acad Sci. 2003. PMID: 12799297
Blockade of Rh efflux using verapamil improved lymphoid reconstitution by enriched HSCs, and isolation of aged HSCs based on efflux of a fluorescent multi-drug resistance (MDR) substrate (Bodipy-verapamil) resulted in enrichment of HSC activity equivalent to that ob …
Blockade of Rh efflux using verapamil improved lymphoid reconstitution by enriched HSCs, and isolation of aged HSCs based on efflux of a flu …
Bile salt-stimulated phospholipid efflux mediated by ABCB4 localized in nonraft membranes.
Morita SY, Tsuda T, Horikami M, Teraoka R, Kitagawa S, Terada T. Morita SY, et al. J Lipid Res. 2013 May;54(5):1221-30. doi: 10.1194/jlr.M032425. Epub 2013 Mar 6. J Lipid Res. 2013. PMID: 23468132 Free PMC article.
The ABCB4-mediated efflux of PC, PE, and SM was significantly stimulated by taurocholate, while the efflux of PE and SM was much less than that of PC. This ABCB4-mediated efflux was completely abolished by BODIPY-verapamil, which hardly partitioned into raft membran …
The ABCB4-mediated efflux of PC, PE, and SM was significantly stimulated by taurocholate, while the efflux of PE and SM was much less than t …
Localization and substrate selectivity of sea urchin multidrug (MDR) efflux transporters.
Gökirmak T, Campanale JP, Shipp LE, Moy GW, Tao H, Hamdoun A. Gökirmak T, et al. J Biol Chem. 2012 Dec 21;287(52):43876-83. doi: 10.1074/jbc.M112.424879. Epub 2012 Nov 2. J Biol Chem. 2012. PMID: 23124201 Free PMC article.
Using this assay, we found that sea urchin MDR transporters export canonical MDR susbtrates such as calcein-AM, bodipy-verapamil, bodipy-vinblastine, and mitoxantrone. In addition, we characterized the impact of nonconservative substitutions in the primary sequences …
Using this assay, we found that sea urchin MDR transporters export canonical MDR susbtrates such as calcein-AM, bodipy-verapamil …
Evidence for the Interaction of A3 Adenosine Receptor Agonists at the Drug-Binding Site(s) of Human P-glycoprotein (ABCB1).
Abel B, Tosh DK, Durell SR, Murakami M, Vahedi S, Jacobson KA, Ambudkar SV. Abel B, et al. Mol Pharmacol. 2019 Aug;96(2):180-192. doi: 10.1124/mol.118.115295. Epub 2019 May 24. Mol Pharmacol. 2019. PMID: 31127007 Free PMC article.
., compound 3 as a stimulator and compound 8 as a partial inhibitor of P-gp ATPase activity). Compound 8 significantly inhibited boron-dipyrromethene (BODIPY)-verapamil transport mediated by human P-gp (IC(50) 2.4 0.6 M); however, the BODIPY-conjugated derivative of …
., compound 3 as a stimulator and compound 8 as a partial inhibitor of P-gp ATPase activity). Compound 8 significantly inhibited boron-dipyr …
28 results