A new myocardial imaging agent: synthesis, characterization, and biodistribution of gallium-68-BAT-TECH

J Nucl Med. 1990 Oct;31(10):1635-40.

Abstract

In order to develop a new myocardial perfusion agent for positron emission tomography (PET), a new lipid-soluble gallium complex was evaluated. Synthesis, radiolabeling, characterization, and biodistribution of a unique gallium complex, [67Ga]BAT-TECH (bis-aminoethanethiol-tetraethyl-cyclohexyl), are described. The complex formation between Ga+3 and BAT-TECH ligand is simple, rapid, and of high yield (greater than or equal to 95%). This process is amenable to kit formulation. The complex has a net charge of +1 and a Ga/ligand ratio of 1:1. Biodistribution in rats shows high uptake in the heart as well as in the liver. When [68Ga] BAT-TECH was injected into a monkey, the heart and liver are clearly delineated by PET imaging, suggesting that this complex may be a possible tracer for myocardial perfusion imaging.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cysteamine / chemical synthesis
  • Cysteamine / chemistry
  • Cysteamine / pharmacokinetics
  • Gallium Radioisotopes*
  • Heart / diagnostic imaging*
  • Isotope Labeling
  • Macaca fascicularis
  • Male
  • Rats
  • Rats, Inbred Strains
  • Tissue Distribution
  • Tomography, Emission-Computed

Substances

  • Gallium Radioisotopes
  • bis(aminoethanethiol)tetraethyl-cyclohexyl-gallium(68) complex
  • Cysteamine