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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 3
1947 2
1948 3
1951 1
1952 1
1953 1
1954 2
1955 7
1956 2
1957 2
1958 3
1959 21
1960 14
1961 10
1962 6
1963 21
1964 49
1965 56
1966 58
1967 52
1968 90
1969 68
1970 71
1971 102
1972 101
1973 111
1974 131
1975 127
1976 144
1977 128
1978 99
1979 124
1980 98
1981 100
1982 120
1983 112
1984 137
1985 182
1986 154
1987 123
1988 119
1989 116
1990 118
1991 110
1992 90
1993 98
1994 112
1995 101
1996 100
1997 91
1998 105
1999 123
2000 118
2001 194
2002 178
2003 274
2004 301
2005 303
2006 278
2007 274
2008 265
2009 278
2010 363
2011 350
2012 361
2013 370
2014 354
2015 354
2016 339
2017 321
2018 304
2019 301
2020 320
2021 292
2022 193
2023 168
2024 94

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10,045 results

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Page 1
Substituted Aryl Benzylamines as Potent and Selective Inhibitors of 17beta-Hydroxysteroid Dehydrogenase Type 3.
Vicker N, Bailey HV, Day JM, Mahon MF, Smith A, Tutill HJ, Purohit A, Potter BVL. Vicker N, et al. Molecules. 2021 Nov 26;26(23):7166. doi: 10.3390/molecules26237166. Molecules. 2021. PMID: 34885749 Free PMC article.
The enzyme is membrane-bound, and a crystal structure is not yet available. Selective aryl benzylamine-based inhibitors were designed and synthesised as potential agents for prostate cancer therapeutics through structure-based design, using a previously built homology mode …
The enzyme is membrane-bound, and a crystal structure is not yet available. Selective aryl benzylamine-based inhibitors were designed …
Ligand-Promoted meta-C-H Functionalization of Benzylamines.
Wang P, Farmer ME, Yu JQ. Wang P, et al. Angew Chem Int Ed Engl. 2017 Apr 24;56(18):5125-5129. doi: 10.1002/anie.201701803. Epub 2017 Mar 30. Angew Chem Int Ed Engl. 2017. PMID: 28371173 Free PMC article.
Meta-C-H functionalization of benzylamines has been developed using a Pd(II) /transient mediator strategy. Using 2-pyridone ligands and 2-carbomethoxynorbornene (NBE-CO(2) Me) as the mediator, arylation, amination, and chlorination of benzylamines are realized. This …
Meta-C-H functionalization of benzylamines has been developed using a Pd(II) /transient mediator strategy. Using 2-pyridone ligands a …
Pd(II)-catalyzed ortho-trifluoromethylation of benzylamines.
Miura M, Feng CG, Ma S, Yu JQ. Miura M, et al. Org Lett. 2013 Oct 18;15(20):5258-61. doi: 10.1021/ol402471y. Epub 2013 Oct 7. Org Lett. 2013. PMID: 24098966
The Pd(II)-catalyzed ortho-C-H trifluoromethylation of benzylamines has been achieved utilizing an electrophilic CF3 reagent. ...This protocol will be useful in medicinal chemistry for the preparation of ortho-trifluoromethyl-substituted benzylamines....
The Pd(II)-catalyzed ortho-C-H trifluoromethylation of benzylamines has been achieved utilizing an electrophilic CF3 reagent. ...This …
Benzylamines: synthesis and evaluation of antimycobacterial properties.
Meindl WR, von Angerer E, Schönenberger H, Ruckdeschel G. Meindl WR, et al. J Med Chem. 1984 Sep;27(9):1111-8. doi: 10.1021/jm00375a005. J Med Chem. 1984. PMID: 6433022
The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. ...
The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Myco …
Kinetic Resolution of Benzylamines via Palladium(II)-Catalyzed C-H Cross-Coupling.
Xiao KJ, Chu L, Chen G, Yu JQ. Xiao KJ, et al. J Am Chem Soc. 2016 Jun 22;138(24):7796-800. doi: 10.1021/jacs.6b04660. Epub 2016 Jun 10. J Am Chem Soc. 2016. PMID: 27249208 Free PMC article.
A Pd(II)-catalyzed enantioselective C-H cross-coupling of benzylamines via kinetic resolution has been achieved using chiral mono-N-protected alpha-amino-O-methylhydroxamic acid (MPAHA) ligands. Both chiral benzylamines and ortho-arylated benzylamines are obt …
A Pd(II)-catalyzed enantioselective C-H cross-coupling of benzylamines via kinetic resolution has been achieved using chiral mono-N-p …
C70 as a Photocatalyst for Oxidation of Secondary Benzylamines to Imines.
Kumar R, Gleissner EH, Tiu EG, Yamakoshi Y. Kumar R, et al. Org Lett. 2016 Jan 15;18(2):184-7. doi: 10.1021/acs.orglett.5b03194. Epub 2015 Dec 23. Org Lett. 2016. PMID: 26700114
Photosensitive C70 was used for the catalytic oxidation of benzylamines to the corresponding imines. The advantages of using C70 compared to C60 or other commonly used photosensitizers such as tetraphenylporphyrin (TPP) are (1) faster reaction rates, especially under lower …
Photosensitive C70 was used for the catalytic oxidation of benzylamines to the corresponding imines. The advantages of using C70 comp …
Butenafine and superficial mycoses: current status.
Singal A. Singal A. Expert Opin Drug Metab Toxicol. 2008 Jul;4(7):999-1005. doi: 10.1517/17425255.4.7.999. Expert Opin Drug Metab Toxicol. 2008. PMID: 18624686 Review.
BACKGROUND: Butenafine hydrochloride, a benzylamine derivative, exhibits potent fungicidal activity particularly against dermatophytes, aspergilli, dimorphic and dematiaceous fungi. ...
BACKGROUND: Butenafine hydrochloride, a benzylamine derivative, exhibits potent fungicidal activity particularly against dermatophyte …
Isotope effects reveal that para-substituted benzylamines are poor reactivity probes of the quinoprotein mechanism for aromatic amine dehydrogenase.
Hothi P, Roujeinikova A, Khadra KA, Lee M, Cullis P, Leys D, Scrutton NS. Hothi P, et al. Biochemistry. 2007 Aug 14;46(32):9250-9. doi: 10.1021/bi7007239. Epub 2007 Jul 18. Biochemistry. 2007. PMID: 17636875
Structure-activity correlations have been employed previously in the mechanistic interpretation of TTQ-dependent amine dehydrogenases using a series of para-substituted benzylamines. However, by combining the use of kinetic isotope effects (KIEs) and crystallographic analy …
Structure-activity correlations have been employed previously in the mechanistic interpretation of TTQ-dependent amine dehydrogenases using …
10,045 results
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