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Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180).
Li J, Chen SY, Li JJ, Wang H, Hernandez AS, Tao S, Musial CM, Qu F, Swartz S, Chao ST, Flynn N, Murphy BJ, Slusarchyk DA, Seethala R, Yan M, Sleph P, Grover G, Smith MA, Beehler B, Giupponi L, Dickinson KE, Zhang H, Humphreys WG, Patel BP, Schwinden M, Stouch T, Cheng PT, Biller SA, Ewing WR, Gordon D, Robl JA, Tino JA. Li J, et al. J Med Chem. 2007 Nov 29;50(24):5890-3. doi: 10.1021/jm7010595. Epub 2007 Oct 31. J Med Chem. 2007. PMID: 17973363
A tetrazole-based peptidomimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS). ...
A tetrazole-based peptidomimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS). ...
Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain.
Li J, Chen SY, Tao S, Wang H, Li JJ, Swartz S, Musial C, Hernandez AA, Flynn N, Murphy BJ, Beehler B, Dickinson KE, Giupponi L, Grover G, Seethala R, Sleph P, Slusarchyk D, Yan M, Humphreys WG, Zhang H, Ewing WR, Robl JA, Gordon D, Tino JA. Li J, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1825-9. doi: 10.1016/j.bmcl.2008.02.021. Epub 2008 Feb 13. Bioorg Med Chem Lett. 2008. PMID: 18295486
The structure-activity relationship of the O-benzyl serine side chain was investigated based on the tetrazole-based growth hormone secretagogue BMS-317180 (2). The ortho position of the benzyl moiety was found to be favorable for introduction of substituents. ...Amo …
The structure-activity relationship of the O-benzyl serine side chain was investigated based on the tetrazole-based growth hormone secretago …
Process research and development for a tetrazole-based growth hormone secretagogue (GHS) pharmaceutical development candidate.
Davulcu AH, McLeod DD, Li J, Katipally K, Littke A, Doubleday W, Xu Z, McConlogue CW, Lai CJ, Gleeson M, Schwinden M, Parsons RL Jr. Davulcu AH, et al. J Org Chem. 2009 Jun 5;74(11):4068-79. doi: 10.1021/jo9003508. J Org Chem. 2009. PMID: 19391593
BMS-317180 (1) is a potent, orally active agonist of the human growth hormone secretagogue (GHS) receptor. ...
BMS-317180 (1) is a potent, orally active agonist of the human growth hormone secretagogue (GHS) receptor. ...