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B-HT 958--an antagonist at alpha 2-adrenoceptors and an agonist at dopamine autoreceptors in the brain.
Hörtnagl H, Pichler L, Holzer-Petsche U, Hornykiewicz O, Kobinger W. Hörtnagl H, et al. Eur J Pharmacol. 1984 Nov 13;106(2):335-44. doi: 10.1016/0014-2999(84)90721-0. Eur J Pharmacol. 1984. PMID: 6152218
In the present experiments the actions of B-HT 958 on brain noradrenergic and dopaminergic mechanisms were examined using behavioural, pharmacological and biochemical methods. ...(v) The gamma-butyrolactone-induced increase in DOPA levels was effectively anta …
In the present experiments the actions of B-HT 958 on brain noradrenergic and dopaminergic mechanisms were examined usi …
B-HT 920 and B-HT 958: presynaptic effects on electrically evoked 3H-dopamine release from slices of rat nucleus accumbens.
Cichini G, Placheta P, Singer EA. Cichini G, et al. Naunyn Schmiedebergs Arch Pharmacol. 1987 Jan;335(1):28-31. doi: 10.1007/BF00165031. Naunyn Schmiedebergs Arch Pharmacol. 1987. PMID: 2883584
Sulpiride (10 mumol/l) completely prevented the effects of B-HT 920 (1 mumol/l) or B-HT 958 (1 mumol/l) at 37 degrees C/5 Hz, whereas phentolamine (1 mumol/l) had no effect on the actions of the two drugs under these experimental conditions. From the patterns …
Sulpiride (10 mumol/l) completely prevented the effects of B-HT 920 (1 mumol/l) or B-HT 958 (1 mumol/l) at 37 degrees C …
B-HT 958, a new alpha-adrenoceptor agonist with a high pre/postsynaptic activity ratio.
Pichler L, Hörtnagl H, Kobinger W. Pichler L, et al. Naunyn Schmiedebergs Arch Pharmacol. 1982 Aug;320(2):110-4. doi: 10.1007/BF00506310. Naunyn Schmiedebergs Arch Pharmacol. 1982. PMID: 6126817
Moreover in isolated perfused cat hearts, the drug inhibited the tachycardia and the outflow of noradrenaline induced by sympathetic nerve impulses. These effects of B-HT 958 were antagonized by phentolamine or yohimbine. At postsynaptic sites high doses of …
Moreover in isolated perfused cat hearts, the drug inhibited the tachycardia and the outflow of noradrenaline induced by sympathetic nerve i …
B-HT 920, B-HT 933, and B-HT 958: presynaptic effects on electrically evoked 3H-noradrenaline release from slices of rat brain cortex and hypothalamus.
Cichini G, Singer EA. Cichini G, et al. Naunyn Schmiedebergs Arch Pharmacol. 1987 Jun;335(6):613-7. doi: 10.1007/BF00166976. Naunyn Schmiedebergs Arch Pharmacol. 1987. PMID: 2888023
The effects of the three azepine compounds, B-HT 920 (6-allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo-[4,5-d]azepine), B-HT 933 [2-amino-6-ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepine; azepexole] and B-HT 958 (2-amino-6-(p-chloro-benzyl)-4H-5,6,7,8-tetrah …
The effects of the three azepine compounds, B-HT 920 (6-allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo-[4,5-d]azepine), B-HT 933 [2-amino-6-et …
B-HT 958 lowers blood pressure and heart rate in the rat through stimulation of dopamine receptors.
Brown MJ, Harland D. Brown MJ, et al. Br J Pharmacol. 1986 Feb;87(2):361-70. doi: 10.1111/j.1476-5381.1986.tb10825.x. Br J Pharmacol. 1986. PMID: 3006858 Free PMC article.
B-HT 958. Plasma noradrenaline was used as an approximate index of peripheral sympathetic nervous activity. ...This combination however had a significantly greater effect in inhibiting B-HT 958 hypotension than had idazoxan 1000 microgram …
B-HT 958. Plasma noradrenaline was used as an approximate index of peripheral sympathetic nervous activity. ...This com …
Cardiovascular effects of B-HT 958, an alpha-adrenoceptor agonist with a high pre/postsynaptic activity ratio.
Kobinger W, Pichler L. Kobinger W, et al. Eur J Pharmacol. 1984 Jan 13;97(1-2):67-73. doi: 10.1016/0014-2999(84)90513-2. Eur J Pharmacol. 1984. PMID: 6141948
Following i.v. infusion in anaesthetized cats, 3 mg/kg of B-HT 958 lowered blood pressure, heart rate, cardiac output and total peripheral vascular resistance. ...In anaesthetized rats the decrease in blood pressure and heart rate caused by 1 mg/kg B- …
Following i.v. infusion in anaesthetized cats, 3 mg/kg of B-HT 958 lowered blood pressure, heart rate, cardiac output a …
B-HT 958 stimulates dopamine autoreceptors but blocks noradrenaline autoreceptors in the brain.
Grabowska-Andén M, Andén NE. Grabowska-Andén M, et al. J Pharm Pharmacol. 1984 Nov;36(11):748-52. doi: 10.1111/j.2042-7158.1984.tb04864.x. J Pharm Pharmacol. 1984. PMID: 6150978
In reserpine-treated mice, B-HT 958 produced a most a weak locomotion and no change in the apomorphine-induced increase in motor activity. The motor activity of normal mice was reduced by B-HT 958. At high doses, B-HT 958 …
In reserpine-treated mice, B-HT 958 produced a most a weak locomotion and no change in the apomorphine-induced increase …
Lack of relationship between intrinsic activity and susceptibility of pressor responses to blockade by nifedipine among the alpha 2-adrenoceptor agonists B-HT 920 and B-HT 958.
Wilffert B, van Heiningen PN, Mathy MJ, Batink HD, de Jonge A, Thoolen MJ, Timmermans PB, van Zwieten PA. Wilffert B, et al. Naunyn Schmiedebergs Arch Pharmacol. 1984 Aug;327(1):90-2. doi: 10.1007/BF00504998. Naunyn Schmiedebergs Arch Pharmacol. 1984. PMID: 6149467
Following i.v. bolus injections into pithed normotensive rats, the maximal diastolic pressor responses to B-HT 920 and B-HT 958 amounted to 115 and 35 mm Hg, respectively. Prazosin (0.1 mg/kg, i.v., -15 min) was without effect on the log dose-pressor effect c …
Following i.v. bolus injections into pithed normotensive rats, the maximal diastolic pressor responses to B-HT 920 and B-HT …
Stimulation of postsynaptic D2- dopamine receptors by B-HT 958 is revealed by co-treatment with the D1- receptor agonist SKF 38393.
Andén NE, Grabowska-Andén M. Andén NE, et al. J Pharm Pharmacol. 1989 Jul;41(7):490-2. doi: 10.1111/j.2042-7158.1989.tb06508.x. J Pharm Pharmacol. 1989. PMID: 2570858
The motor activity of reserpine-treated mice was used to study effects of B-HT 958 (2-amino-6-(p-chlorobenzyl)-4H-5,6,7,8-tetrahydrothiazolo-[5,4-d]- azepine) on postsynaptic dopamine and noradrenaline receptors. The motor activity was only slightly stimulate …
The motor activity of reserpine-treated mice was used to study effects of B-HT 958 (2-amino-6-(p-chlorobenzyl)-4H-5,6,7 …
Effect of the D2-autoreceptor agonist B-HT 958 on both spontaneous and ACTH-induced stretching, yawning and grooming in the rat.
Ferrari F, Pelloni F, Filaferro M, Giuliani D. Ferrari F, et al. Life Sci. 1992;50(14):1013-9. doi: 10.1016/0024-3205(92)90096-8. Life Sci. 1992. PMID: 1348099
The D2 autoreceptor agonist B-HT 958, intraperitoneally injected into Wistar male rats in a novel environment, significantly increased stretching and yawning (SY) while inhibiting grooming. Pretreatment with the D2 antagonist sulpiride reversed these effects, …
The D2 autoreceptor agonist B-HT 958, intraperitoneally injected into Wistar male rats in a novel environment, signific …
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