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Avicin D selectively induces apoptosis and downregulates p-STAT-3, bcl-2, and survivin in cutaneous T-cell lymphoma cells.
Zhang C, Li B, Gaikwad AS, Haridas V, Xu Z, Gutterman JU, Duvic M. Zhang C, et al. J Invest Dermatol. 2008 Nov;128(11):2728-2735. doi: 10.1038/jid.2008.138. Epub 2008 May 22. J Invest Dermatol. 2008. PMID: 18496567 Free article.
The general caspase inhibitor Z-VAD-FMK and caspase-3 inhibitor Z-DEVD-FMK decreased avicin D-induced apoptosis in CTCL cells. Caspase-3 was activated and poly (ADP-ribose) polymerase was cleaved after avicin D treatment. ...Our findings underlie the t …
The general caspase inhibitor Z-VAD-FMK and caspase-3 inhibitor Z-DEVD-FMK decreased avicin D-induced apoptosis in CTCL cells. …
The anticancer plant triterpenoid, avicin D, regulates glucocorticoid receptor signaling: implications for cellular metabolism.
Haridas V, Xu ZX, Kitchen D, Jiang A, Michels P, Gutterman JU. Haridas V, et al. PLoS One. 2011;6(11):e28037. doi: 10.1371/journal.pone.0028037. Epub 2011 Nov 21. PLoS One. 2011. PMID: 22132201 Free PMC article.
These structural and functional similarities prompted us to compare the mode of action of avicin D with dexamethasone (Dex), a prototypical GC. Using cold competition assay, we show that Avicin D competes with Dex for binding to the GC receptor (GR), l …
These structural and functional similarities prompted us to compare the mode of action of avicin D with dexamethasone (Dex), a …
A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase.
Xu ZX, Liang J, Haridas V, Gaikwad A, Connolly FP, Mills GB, Gutterman JU. Xu ZX, et al. Cell Death Differ. 2007 Nov;14(11):1948-57. doi: 10.1038/sj.cdd.4402207. Epub 2007 Aug 10. Cell Death Differ. 2007. PMID: 17690712
Avicin D decreases cellular ATP levels, stimulates the activation of AMP-activated protein kinase (AMPK), and inhibits mammalian target of rapamycin (mTOR) and S6 kinase activity. Suppression of AMPK by compound C and dominant-negative AMPK decreases avicin …
Avicin D decreases cellular ATP levels, stimulates the activation of AMP-activated protein kinase (AMPK), and inhibits mammali …
Avicin D, a plant triterpenoid, induces cell apoptosis by recruitment of Fas and downstream signaling molecules into lipid rafts.
Xu ZX, Ding T, Haridas V, Connolly F, Gutterman JU. Xu ZX, et al. PLoS One. 2009 Dec 31;4(12):e8532. doi: 10.1371/journal.pone.0008532. PLoS One. 2009. PMID: 20046832 Free PMC article.
Interfering with lipid raft organization by using a cholesterol-depleting compound, methyl-beta-cyclodextrin, not only prevents the clustering of Fas and its DISC complex but also reduces the sensitivity of the cells to avicin D. Avicin D activates Fas …
Interfering with lipid raft organization by using a cholesterol-depleting compound, methyl-beta-cyclodextrin, not only prevents the clusteri …
Proapoptotic triterpene electrophiles (avicins) form channels in membranes: cholesterol dependence.
Li XX, Davis B, Haridas V, Gutterman JU, Colombini M. Li XX, et al. Biophys J. 2005 Apr;88(4):2577-84. doi: 10.1529/biophysj.104.049403. Epub 2005 Jan 14. Biophys J. 2005. PMID: 15653745 Free PMC article.
A small difference in this side chain results in strong cholesterol dependence of channel formation in avicin G that is not found in avicin D. In neutral membranes, avicin channels are nonselective, but negatively-charged lipids confer cation selectivity (5:1, K(+): …
A small difference in this side chain results in strong cholesterol dependence of channel formation in avicin G that is not found in avic …
Red blood cell permeabilization by hypotonic treatments, saponin, and anticancer avicins.
Arias M, Quijano JC, Haridas V, Gutterman JU, Lemeshko VV. Arias M, et al. Biochim Biophys Acta. 2010 Jun;1798(6):1189-96. doi: 10.1016/j.bbamem.2010.03.018. Epub 2010 Mar 24. Biochim Biophys Acta. 2010. PMID: 20346345 Free article.
Using the "osmotic protection" method with 100mOsm PEGs of increasing molecular weight in isotonic media, the size of the pores generated by avicin G and avicin D in the plasma membrane was estimated to be higher than the hydrodynamic radius of PEG-8000. The obtaine …
Using the "osmotic protection" method with 100mOsm PEGs of increasing molecular weight in isotonic media, the size of the pores generated by …
Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery.
Haridas V, Hanausek M, Nishimura G, Soehnge H, Gaikwad A, Narog M, Spears E, Zoltaszek R, Walaszek Z, Gutterman JU. Haridas V, et al. J Clin Invest. 2004 Jan;113(1):65-73. doi: 10.1172/JCI18699. J Clin Invest. 2004. PMID: 14702110 Free PMC article.
The presence of two alpha,beta unsaturated carbonyl groups (Michael reaction sites) in the side chain of the avicin molecule prompted us to study its effects on NF-E2-related factor 2 (Nrf2), a redox-regulated transcription factor that controls the expression of a battery of deto …
The presence of two alpha,beta unsaturated carbonyl groups (Michael reaction sites) in the side chain of the avicin molecule prompted us to …
Glycosylation facilitates transdermal transport of macromolecules.
Pino CJ, Gutterman JU, Vonwil D, Mitragotri S, Shastri VP. Pino CJ, et al. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21283-8. doi: 10.1073/pnas.1200942109. Epub 2012 Dec 10. Proc Natl Acad Sci U S A. 2012. PMID: 23236155 Free PMC article.
12 results