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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2010 1
2011 3
2012 6
2013 4
2014 4
2015 3
2016 4
2017 6
2018 6
2019 4
2020 8
2021 11
2022 10
2023 10
2024 3

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72 results

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Page 1
Advances and Perspectives in the Management of Varicella-Zoster Virus Infections.
Andrei G, Snoeck R. Andrei G, et al. Molecules. 2021 Feb 20;26(4):1132. doi: 10.3390/molecules26041132. Molecules. 2021. PMID: 33672709 Free PMC article. Review.
We also focus on acyclovir, valacyclovir, and famciclovir (FDA approved drugs to treat VZV infections), brivudine (used in some European countries) and amenamevir (a helicase-primase inhibitor, approved in Japan) that augur the beginning of a new era of anti-VZV therapy. . …
We also focus on acyclovir, valacyclovir, and famciclovir (FDA approved drugs to treat VZV infections), brivudine (used in some European cou …
Amenamevir, a Helicase-Primase Inhibitor, for the Optimal Treatment of Herpes Zoster.
Shiraki K, Yasumoto S, Toyama N, Fukuda H. Shiraki K, et al. Viruses. 2021 Aug 5;13(8):1547. doi: 10.3390/v13081547. Viruses. 2021. PMID: 34452412 Free PMC article. Review.
Among HPIs, amenamevir has anti-VZV activity. The concentrations of HSV-1 and VZV required for the 50% plaque reduction of amenamevir were 0.036 and 0.047 muM, respectively. ...The clinical efficacy and safety profiles of amenamevir were established in patien …
Among HPIs, amenamevir has anti-VZV activity. The concentrations of HSV-1 and VZV required for the 50% plaque reduction of amename …
Antiviral Drugs Against Alphaherpesvirus.
Shiraki K. Shiraki K. Adv Exp Med Biol. 2018;1045:103-122. doi: 10.1007/978-981-10-7230-7_6. Adv Exp Med Biol. 2018. PMID: 29896665 Review.
Helicase-primase plays an initial step in DNA synthesis to separate the double strand into two single strands (replication fork) and is a new target of antiviral therapy. The helicase-primase inhibitors (HPIs) pritelivir and amenamevir have novel mechanisms of action, drug …
Helicase-primase plays an initial step in DNA synthesis to separate the double strand into two single strands (replication fork) and is a ne …
Helicase-primase inhibitor amenamevir for herpesvirus infection: Towards practical application for treating herpes zoster.
Shiraki K. Shiraki K. Drugs Today (Barc). 2017 Nov;53(11):573-584. doi: 10.1358/dot.2017.53.11.2724803. Drugs Today (Barc). 2017. PMID: 29451274 Review.
A clinical trial of amenamevir for herpes zoster has been completed, and amenamevir has been licensed and successfully used in 20,000 patients with herpes zoster so far in Japan. ...Amenamevir is opening a new era of antiherpes therapy....
A clinical trial of amenamevir for herpes zoster has been completed, and amenamevir has been licensed and successfully used in …
Profile of anti-herpetic action of ASP2151 (amenamevir) as a helicase-primase inhibitor.
Yajima M, Yamada H, Takemoto M, Daikoku T, Yoshida Y, Long T, Okuda T, Shiraki K. Yajima M, et al. Antiviral Res. 2017 Mar;139:95-101. doi: 10.1016/j.antiviral.2016.12.008. Epub 2016 Dec 24. Antiviral Res. 2017. PMID: 28027917
The antiherpetic drugs acyclovir (ACV, valaciclovir) and penciclovir (famciclovir) are phosphorylated by viral thymidine kinase and terminate DNA synthesis. ASP2151 (amenamevir) and foscavir (PFA) directly inhibit viral helicase-primase and DNA polymerase, respectiv …
The antiherpetic drugs acyclovir (ACV, valaciclovir) and penciclovir (famciclovir) are phosphorylated by viral thymidine kinase and terminat …
Pharmaceuticals and Medical Device Agency approval summary: Amenamevir for the treatment of herpes zoster.
Shoji N, Tanese K, Sasaki A, Horiuchi T, Utsuno Y, Fukuda K, Hoshino Y, Noda S, Minami H, Asakura W; Amenamevir Review Team. Shoji N, et al. J Dermatol. 2020 Jul;47(7):683-688. doi: 10.1111/1346-8138.15393. Epub 2020 May 18. J Dermatol. 2020. PMID: 32424854 Review.
Amenamevir has a different action mechanism from previously approved synthetic nucleoside compounds for the treatment of HZ including acyclovir, valacyclovir and famciclovir. The usual adult dose is 400 mg amenamevir p.o. once daily for 7 days. The benefit is its ab …
Amenamevir has a different action mechanism from previously approved synthetic nucleoside compounds for the treatment of HZ including …
Current scenario and future applicability of antivirals against herpes zoster.
Kim SH. Kim SH. Korean J Pain. 2023 Jan 1;36(1):4-10. doi: 10.3344/kjp.22391. Korean J Pain. 2023. PMID: 36573010 Free PMC article. Review.
However, limited antivirals are only licensed clinically for the treatment of HZ, including acyclovir, valacyclovir, famciclovir, brivudine, and amenamevir. Fortunately, some new antivirals against different types of Herpesviridae have been investigated and suggested as no …
However, limited antivirals are only licensed clinically for the treatment of HZ, including acyclovir, valacyclovir, famciclovir, brivudine, …
Statistical analysis of Amenamevir (ASP2151) between pharmacokinetics and clinical efficacies with non-linear effect model for the treatment of genital herpes.
Takada A, Katashima M, Kaibara A, Sawamoto T, Zhang W, Keirns J. Takada A, et al. Clin Pharmacol Drug Dev. 2014 Sep;3(5):365-70. doi: 10.1002/cpdd.108. Epub 2014 Feb 17. Clin Pharmacol Drug Dev. 2014. PMID: 27129009 Clinical Trial.
Amenamevir is the international non-proprietary name for ASP2151 synthesized by Astellas Pharma, Inc. ...Participants self-initiated with ASP2151 (100, 200, or 400 mg daily for 3 days), ASP2151 (1,200 mg as a single dose), placebo for 3 days, or Valacy …
Amenamevir is the international non-proprietary name for ASP2151 synthesized by Astellas Pharma, Inc. ...Participants self-ini …
72 results