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1-[4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1- piperidinyl]propoxy]-3-methoxyphenyl]ethanone(AHR-5333): a selective human blood neutrophil 5-lipoxygenase inhibitor.
Graff G, Anderson LA. Graff G, et al. Prostaglandins. 1989 Oct;38(4):473-96. doi: 10.1016/0090-6980(89)90130-5. Prostaglandins. 1989. PMID: 2554366
In this study we report the in vitro inhibition of leukotriene synthesis in calcium ionophore (A23187)-stimulated, intact human blood neutrophils by AHR-5333. The results showed that AHR-5333 inhibits 5-HETE, LTB4 and LTC4 synthesis with IC50 values of …
In this study we report the in vitro inhibition of leukotriene synthesis in calcium ionophore (A23187)-stimulated, intact human blood neutro …
Effects of AHR-5333, a new potential antiallergy compound, in in vivo models of immediate hypersensitivity.
Yanni JM, Foxwell MH. Yanni JM, et al. Int Arch Allergy Appl Immunol. 1988;85(4):428-33. doi: 10.1159/000234546. Int Arch Allergy Appl Immunol. 1988. PMID: 2895747
AHR-5333 [1-[4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl] propoxy]-3-methoxyphenyl]ethanone] possessed potent, long-acting activity in rat and guinea pig in vivo models of immediate hypersensitivity: AHR-5333 was more potent than azatadine …
AHR-5333 [1-[4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl] propoxy]-3-methoxyphenyl]ethanone] possessed potent, lo …
Synthesis and antiallergy activity of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl]piperidines and structurally related compounds.
Walsh DA, Franzyshen SK, Yanni JM. Walsh DA, et al. J Med Chem. 1989 Jan;32(1):105-18. doi: 10.1021/jm00121a022. J Med Chem. 1989. PMID: 2562852
In particular 1-[4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl] propoxy]-3-methoxyphenyl]ethanone (1, AHR-5333) was more potent than oxatomide and terfenadine in this assay....
In particular 1-[4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl] propoxy]-3-methoxyphenyl]ethanone (1, AHR-5333) was …