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Page 1
Thiazole Containing Heterocycles with Antimalarial Activity.
Kumawat MK. Kumawat MK. Curr Drug Discov Technol. 2018;15(3):196-200. doi: 10.2174/1570163814666170725114159. Curr Drug Discov Technol. 2018. PMID: 28745209 Review.
Thiazole, heterocyclic nucleus is present in several potent pharmacologically active molecules such as Sulfathiazole (antimicrobial drug), Ritonavir (antiretroviral drug), Tiazofurin (antineoplastic drug) and Abafungin (antifungal drug) etc. The search for some novel biolo …
Thiazole, heterocyclic nucleus is present in several potent pharmacologically active molecules such as Sulfathiazole (antimicrobial drug), R …
Bioactive thiazole and benzothiazole derivatives.
Rouf A, Tanyeli C. Rouf A, et al. Eur J Med Chem. 2015 Jun 5;97:911-27. doi: 10.1016/j.ejmech.2014.10.058. Epub 2014 Oct 22. Eur J Med Chem. 2015. PMID: 25455640 Review.
They possess a broad range of biological activities and are found in many potent biologically active molecules and drugs such as vitamin thiamine, sulfathiazol (antimicrobial drug), ritonavir (antiretroviral drug), abafungin (antifungal drug) and tiazofurin (antineoplastic …
They possess a broad range of biological activities and are found in many potent biologically active molecules and drugs such as vitamin thi …
1,3-thiazole Derivatives: A Scaffold with Considerable Potential in the Treatment of Neurodegenerative Diseases.
Chaudhary J, Jain A, Dhingra A, Chopra B, Sharma V, Gupta J, Kaushik A. Chaudhary J, et al. Curr Top Med Chem. 2023;23(23):2185-2196. doi: 10.2174/1568026623666230719124850. Curr Top Med Chem. 2023. PMID: 37469159 Review.
The presence of the thiazole moiety has resulted in a large number of clinically useful drugs with a wide range of activities, such as Ritonavir (antiviral), Sulfathiazole (antimicrobial antibiotic), Abafungin, Ravuconazole (antifungal), Meloxicam (NSAID), etc., that furth …
The presence of the thiazole moiety has resulted in a large number of clinically useful drugs with a wide range of activities, such as Riton …
Thiazole: A Review on Chemistry, Synthesis and Therapeutic Importance of its Derivatives.
Chhabria MT, Patel S, Modi P, Brahmkshatriya PS. Chhabria MT, et al. Curr Top Med Chem. 2016;16(26):2841-2862. doi: 10.2174/1568026616666160506130731. Curr Top Med Chem. 2016. PMID: 27150376 Review.
The versatility of thiazole nucleus demonstrated by the fact that it is an essential part of penicillin nucleus and some of its derivatives which have shown antimicrobial (sulfazole), antiretroviral (ritonavir), antifungal (abafungin), antihistaminic and antithyroid activi …
The versatility of thiazole nucleus demonstrated by the fact that it is an essential part of penicillin nucleus and some of its derivatives …
Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungi.
Borelli C, Schaller M, Niewerth M, Nocker K, Baasner B, Berg D, Tiemann R, Tietjen K, Fugmann B, Lang-Fugmann S, Korting HC. Borelli C, et al. Chemotherapy. 2008;54(4):245-59. doi: 10.1159/000142334. Epub 2008 Jun 30. Chemotherapy. 2008. PMID: 18587237 Free PMC article.
A second action of abafungin seems to be a direct effect on the fungal cell membrane. CONCLUSION: The observed characteristics of abafungin indicate that abafungin might be a promising antifungal agent defining a new class of antimycotics....
A second action of abafungin seems to be a direct effect on the fungal cell membrane. CONCLUSION: The observed characteristics of …
Gateways to clinical trials.
Tomillero A, Moral MA. Tomillero A, et al. Methods Find Exp Clin Pharmacol. 2010 Jan-Feb;32(1):47-86. Methods Find Exp Clin Pharmacol. 2010. PMID: 20383346
(-)-Epigallocatechin gallate, Abafungin, ACE-031, Adapalene/benzoyl peroxide, AE-37, Aflibercept, AGS-003, Albiglutide, Alemtuzumab, Aliskiren fumarate, ALT-801, AN-2728, Anacetrapib, API, Aprepitant, ARQ-197, Ascorbic acid, Atazanavir sulfate, ATN-224, AVI-4658, Azacitidi …
(-)-Epigallocatechin gallate, Abafungin, ACE-031, Adapalene/benzoyl peroxide, AE-37, Aflibercept, AGS-003, Albiglutide, Alemtuzumab, …
Stereoselective synthesis, X-ray analysis, computational studies and biological evaluation of new thiazole derivatives as potential anticancer agents.
Mabkhot YN, Alharbi MM, Al-Showiman SS, Ghabbour HA, Kheder NA, Soliman SM, Frey W. Mabkhot YN, et al. Chem Cent J. 2018 May 11;12(1):56. doi: 10.1186/s13065-018-0420-7. Chem Cent J. 2018. PMID: 29748782 Free PMC article.
Also , many drugs containing thiazole ring in their skeletons are available in the market such as Abafungin, Acotiamide, Alagebrium, Amiphenazole, Brecanavir, Carumonam, Cefepime, and Cefmatilen. ...
Also , many drugs containing thiazole ring in their skeletons are available in the market such as Abafungin, Acotiamide, Alagebrium, …