Pyrrole-Based Macrocyclic Small-Molecule Inhibitors That Target Oocyte Maturation.
Gunasekaran P, Lee SR, Jeong SM, Kwon JW, Takei T, Asahina Y, Bang G, Kim S, Ahn M, Ryu EK, Kim HN, Nam KY, Shin SY, Hojo H, Namgoong S, Kim NH, Bang JK.
Gunasekaran P, et al.
ChemMedChem. 2017 Apr 20;12(8):580-589. doi: 10.1002/cmdc.201700048. Epub 2017 Mar 28.
ChemMedChem. 2017.
PMID: 28296169
Polo-like kinase 1 (PLK1) plays crucial roles in various stages of oocyte maturation. Recently, we reported that the peptidomimetic compound AB103-8, which targets the polo box domain (PBD) of PLK1, affects oocyte meiotic maturation and the resumption of meiosis. ...
Polo-like kinase 1 (PLK1) plays crucial roles in various stages of oocyte maturation. Recently, we reported that the peptidomimetic compound …