Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 1
2007 2
2008 4
2009 3
2010 5
2011 4
2012 2
2013 1
2014 1
2015 2
2016 1
2017 1
2020 2
2021 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

23 results

Results by year

Filters applied: . Clear all
Page 1
Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties.
Tietje KR, Anderson DJ, Bitner RS, Blomme EA, Brackemeyer PJ, Briggs CA, Browman KE, Bury D, Curzon P, Drescher KU, Frost JM, Fryer RM, Fox GB, Gronlien JH, Håkerud M, Gubbins EJ, Halm S, Harris R, Helfrich RJ, Kohlhaas KL, Law D, Malysz J, Marsh KC, Martin RL, Meyer MD, Molesky AL, Nikkel AL, Otte S, Pan L, Puttfarcken PS, Radek RJ, Robb HM, Spies E, Thorin-Hagene K, Waring JF, Ween H, Xu H, Gopalakrishnan M, Bunnelle WH. Tietje KR, et al. CNS Neurosci Ther. 2008 Spring;14(1):65-82. doi: 10.1111/j.1527-3458.2008.00037.x. CNS Neurosci Ther. 2008. PMID: 18482100 Free PMC article. Review.
In this review, we describe the properties of a novel biaryl diamine alpha7 nAChR agonist, A-582941. A-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent dist …
In this review, we describe the properties of a novel biaryl diamine alpha7 nAChR agonist, A-582941. A-582941 wa …
2-[11C]Methyl-5-[6-phenylpyridazine-3-yl]octahydropyrrolo[3,4-c]pyrrole.
Leung K. Leung K. 2010 Oct 12 [updated 2011 Jan 14]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2010 Oct 12 [updated 2011 Jan 14]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 21290619 Free Books & Documents. Review.
In this chapter, another alpha7 nAChR agonist, 2-[(11)C]methyl-5-[6-phenylpyridazine-3-yl]octahydropyrrolo[3,4-c]pyrrole ([(11)C]A-582941) (15), is being evaluated as a useful PET imaging agent....
In this chapter, another alpha7 nAChR agonist, 2-[(11)C]methyl-5-[6-phenylpyridazine-3-yl]octahydropyrrolo[3,4-c]pyrrole ([(11)C]A- …
In vivo evaluation of alpha7 nicotinic acetylcholine receptor agonists [11C]A-582941 and [11C]A-844606 in mice and conscious monkeys.
Toyohara J, Ishiwata K, Sakata M, Wu J, Nishiyama S, Tsukada H, Hashimoto K. Toyohara J, et al. PLoS One. 2010 Feb 1;5(2):e8961. doi: 10.1371/journal.pone.0008961. PLoS One. 2010. PMID: 20126539 Free PMC article.
Dynamic PET scans were performed in conscious monkeys with/without SSR180711-treatment. [(11)C]A-582941 and [(11)C]A-844606 showed high uptake in the mouse brain. ...CONCLUSIONS/SIGNIFICANCE: A nonhuman primate study suggests that [(11)C]A-582941 and [ …
Dynamic PET scans were performed in conscious monkeys with/without SSR180711-treatment. [(11)C]A-582941 and [(11)C]A-844606 sh …
The selective alpha7 nicotinic acetylcholine receptor agonist A-582941 activates immediate early genes in limbic regions of the forebrain: Differential effects in the juvenile and adult rat.
Thomsen MS, Mikkelsen JD, Timmermann DB, Peters D, Hay-Schmidt A, Martens H, Hansen HH. Thomsen MS, et al. Neuroscience. 2008 Jun 23;154(2):741-53. doi: 10.1016/j.neuroscience.2008.03.083. Epub 2008 Apr 16. Neuroscience. 2008. PMID: 18495359
The A-582941-induced c-Fos protein expression was significantly greater in the mPFC and VO/LO of juvenile compared with adult rats. These data indicate that A-582941-induced alpha7 nAChR stimulation activates brain regions critically involved in workin …
The A-582941-induced c-Fos protein expression was significantly greater in the mPFC and VO/LO of juvenile compared with adult …
Profile of nicotinic acetylcholine receptor agonists ABT-594 and A-582941, with differential subtype selectivity, on delayed matching accuracy by young monkeys.
Buccafusco JJ, Terry AV Jr, Decker MW, Gopalakrishnan M. Buccafusco JJ, et al. Biochem Pharmacol. 2007 Oct 15;74(8):1202-11. doi: 10.1016/j.bcp.2007.07.010. Epub 2007 Jul 14. Biochem Pharmacol. 2007. PMID: 17706609
ABT-594 and A-582941 are high affinity neuronal nicotinic acetylcholine receptor agonists with differential selectivity for the alpha4beta2 and the alpha7 subtypes, respectively. ...A-582941 also failed to sustain task improvement during sessions run 2 …
ABT-594 and A-582941 are high affinity neuronal nicotinic acetylcholine receptor agonists with differential selectivity for th …
Pro-cognitive activity in rats of 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor.
Potasiewicz A, Kos T, Ravazzini F, Puia G, Arias HR, Popik P, Nikiforuk A. Potasiewicz A, et al. Br J Pharmacol. 2015 Nov;172(21):5123-35. doi: 10.1111/bph.13277. Epub 2015 Oct 10. Br J Pharmacol. 2015. PMID: 26276349 Free PMC article.
To determine potential drug interactions, an inactive dose of PAM-2 (0.5 mg.kg(-1) ) was co-injected with inactive doses of either agonist - DMXBA: 0.1 (NORT); 0.3 mg.kg(-1) (ASST) or A-582941: 0.1 mg.kg(-1) . KEY RESULTS: PAM-2, DMXBA, and A-582941 im …
To determine potential drug interactions, an inactive dose of PAM-2 (0.5 mg.kg(-1) ) was co-injected with inactive doses of either agonist - …
Effects of α7 nicotinic acetylcholine receptor agonists on antipsychotic efficacy in a preclinical mouse model of psychosis.
Kohlhaas KL, Bitner RS, Gopalakrishnan M, Rueter LE. Kohlhaas KL, et al. Psychopharmacology (Berl). 2012 Apr;220(4):823-33. doi: 10.1007/s00213-011-2535-6. Epub 2011 Oct 29. Psychopharmacology (Berl). 2012. PMID: 22038534
OBJECTIVE: We evaluated the effects of the combination of alpha7 nAChR agonists ABT-107 (0.1-10.0 mg/kg i.p.), A-582941 (0.04-4.0 mg/kg i.p.), and PNU282987 (1.0-10.0 mg/kg i.p.) with risperidone (0.1-1.0 mg/kg i.p.) or haloperidol (0.3-3.0 mg/kg i.p.), representati …
OBJECTIVE: We evaluated the effects of the combination of alpha7 nAChR agonists ABT-107 (0.1-10.0 mg/kg i.p.), A-582941 (0.04- …
α7 nicotinic receptor agonist and positive allosteric modulators differently improved schizophrenia-like cognitive deficits in male rats.
Unal G, Sirvanci S, Aricioglu F. Unal G, et al. Behav Brain Res. 2021 Jan 15;397:112946. doi: 10.1016/j.bbr.2020.112946. Epub 2020 Oct 1. Behav Brain Res. 2021. PMID: 33011186
This study comparatively investigated the effect of alpha7 nAChR agonist (A-582941), type I PAM (CCMI), type II PAM (PNU-120596), and the antipsychotic drug (clozapine) on behavioral, molecular, and immunohistochemical parameters in a subchronic MK-801 model of schi …
This study comparatively investigated the effect of alpha7 nAChR agonist (A-582941), type I PAM (CCMI), type II PAM (PNU-12059 …
Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors reverse ketamine-induced schizophrenia-like deficits in rats.
Nikiforuk A, Kos T, Hołuj M, Potasiewicz A, Popik P. Nikiforuk A, et al. Neuropharmacology. 2016 Feb;101:389-400. doi: 10.1016/j.neuropharm.2015.07.034. Epub 2015 Jul 29. Neuropharmacology. 2016. PMID: 26232639
PNU-120596, CCMI, galantamine and A-582941 reversed ketamine-induced cognitive inflexibility, as assessed in the attentional set-shifting task (ASST). The tested compounds were also effective against ketamine-induced impairment in the novel object recognition task ( …
PNU-120596, CCMI, galantamine and A-582941 reversed ketamine-induced cognitive inflexibility, as assessed in the attentional s …
Type I and II positive allosteric modulators differentially modulate agonist-induced up-regulation of α7 nicotinic acetylcholine receptors.
Thomsen MS, Mikkelsen JD. Thomsen MS, et al. J Neurochem. 2012 Oct;123(1):73-83. doi: 10.1111/j.1471-4159.2012.07876.x. Epub 2012 Aug 16. J Neurochem. 2012. PMID: 22804734 Free article.
Contrarily, neither type I nor II PAMs affect 10 muM nicotine-induced receptor up-regulation, suggesting that nicotine and A-582941 induce up-regulation through different mechanisms. We further show in vivo that 3 mg/kg PNU-120596 inhibits up-regulation of the alpha …
Contrarily, neither type I nor II PAMs affect 10 muM nicotine-induced receptor up-regulation, suggesting that nicotine and A-58294
23 results