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Page 1
The TRPM4 channel inhibitor 9-phenanthrol.
Guinamard R, Hof T, Del Negro CA. Guinamard R, et al. Br J Pharmacol. 2014 Apr;171(7):1600-13. doi: 10.1111/bph.12582. Br J Pharmacol. 2014. PMID: 24433510 Free PMC article. Review.
Among promising potential applications, 9-phenanthrol exerts cardioprotective effects against ischaemia-reperfusion injuries and reduces ischaemic stroke injuries. In addition to reviewing the biophysical effects of 9-phenanthrol, here we present infor …
Among promising potential applications, 9-phenanthrol exerts cardioprotective effects against ischaemia-reperfusion injuries a …
9-Phenanthrol inhibits recombinant and arterial myocyte TMEM16A channels.
Burris SK, Wang Q, Bulley S, Neeb ZP, Jaggar JH. Burris SK, et al. Br J Pharmacol. 2015 May;172(10):2459-68. doi: 10.1111/bph.13077. Epub 2015 Mar 24. Br J Pharmacol. 2015. PMID: 25573456 Free PMC article.
In contrast, 9-phenanthrol did not alter recombinant bestrophin-1 currents. 9-Phenanthrol reduced arterial myocyte TMEM16A currents with an IC50 of 12 muM. ...CONCLUSIONS AND IMPLICATIONS: These data identify 9-phenanthrol as a novel TMEM …
In contrast, 9-phenanthrol did not alter recombinant bestrophin-1 currents. 9-Phenanthrol reduced arterial myocy …
The TRPM4 channel inhibitor 9-phenanthrol alleviates cerebral edema after traumatic brain injury in rats.
Ma P, Huang N, Tang J, Zhou Z, Xu J, Chen Y, Zhang M, Huang Q, Cheng Y. Ma P, et al. Front Pharmacol. 2023 Feb 14;14:1098228. doi: 10.3389/fphar.2023.1098228. eCollection 2023. Front Pharmacol. 2023. PMID: 36865920 Free PMC article.
Upregulation of transient receptor potential melastatin 4 (TRPM4) in vascular endothelial cells (ECs) results in damage to capillaries and the blood-brain barrier (BBB), which is critical for the development of CE. Many studies have shown that 9-phenanthrol (9-PH) e …
Upregulation of transient receptor potential melastatin 4 (TRPM4) in vascular endothelial cells (ECs) results in damage to capillaries and t …
9-Phenanthrol, a TRPM4 inhibitor, protects isolated rat hearts from ischemia-reperfusion injury.
Wang J, Takahashi K, Piao H, Qu P, Naruse K. Wang J, et al. PLoS One. 2013 Jul 25;8(7):e70587. doi: 10.1371/journal.pone.0070587. Print 2013. PLoS One. 2013. PMID: 23936231 Free PMC article.
Thus, the aim of this study was to examine the possible cardioprotective effect of 9-phenanthrol, a specific inhibitor of TRPM4. Isolated Langendorff-perfused rat hearts were pretreated with Krebs-Henseleit (K-H) solution (control), 9-phenanthrol, or 5 …
Thus, the aim of this study was to examine the possible cardioprotective effect of 9-phenanthrol, a specific inhibitor of TRPM …
TRPM4 in cardiac electrical activity.
Guinamard R, Bouvagnet P, Hof T, Liu H, Simard C, Sallé L. Guinamard R, et al. Cardiovasc Res. 2015 Oct 1;108(1):21-30. doi: 10.1093/cvr/cvv213. Epub 2015 Aug 13. Cardiovasc Res. 2015. PMID: 26272755 Review.
Its functional expression was demonstrated in cardiomyocytes of several mammalian species including humans, but the channel is also present in many other tissues. The recent characterization of the TRPM4 inhibitor 9-phenanthrol, and the availability of transgenic mi …
Its functional expression was demonstrated in cardiomyocytes of several mammalian species including humans, but the channel is also present …
A TRPM4 Inhibitor 9-Phenanthrol Inhibits Glucose- and Glucagon-Like Peptide 1-Induced Insulin Secretion from Rat Islets of Langerhans.
Ma Z, Björklund A, Islam MS. Ma Z, et al. J Diabetes Res. 2017;2017:5131785. doi: 10.1155/2017/5131785. Epub 2017 Oct 2. J Diabetes Res. 2017. PMID: 29098165 Free PMC article.
When applied to the islets in the presence of 3.3 mM glucose, 9-phenanthrol caused a small increase in insulin secretion (~7% of the insulin secretion stimulated by 10 mM glucose). 10 muM 9-phenanthrol did not inhibit glucose- or GLP-1-induced insulin …
When applied to the islets in the presence of 3.3 mM glucose, 9-phenanthrol caused a small increase in insulin secretion (~7% …
TRPM4 contribution in mouse uterine contractions.
Fouchet A, Bangando HM, Aize M, Simard C, Guinamard R. Fouchet A, et al. Reproduction. 2023 Jun 19;166(2):77-87. doi: 10.1530/REP-22-0484. Print 2023 Aug 1. Reproduction. 2023. PMID: 37204208
The effect of 9-phenanthrol was significantly reduced in Trpm4-/- rings. The effect of oxytocin was tested and was found to be stronger in Trpm4+/+ rings compared to Trpm4-/-. Under a constant stimulation by oxytocin, 9-phenanthrol still reduced contra …
The effect of 9-phenanthrol was significantly reduced in Trpm4-/- rings. The effect of oxytocin was tested and was found to be …
TRPM4 channel inhibitors 9-phenanthrol and glibenclamide differentially decrease guinea pig detrusor smooth muscle whole-cell cation currents and phasic contractions.
Malysz J, Maxwell SE, Yarotskyy V, Petkov GV. Malysz J, et al. Am J Physiol Cell Physiol. 2020 Feb 1;318(2):C406-C421. doi: 10.1152/ajpcell.00055.2019. Epub 2019 Dec 18. Am J Physiol Cell Physiol. 2020. PMID: 31851526 Free PMC article.
In comparison to 9-phenanthrol, glibenclamide (100 muM) displayed lower inhibition of cation currents. ...This study advances our understanding of pharmacological effects of glibenclamide and 9-phenanthrol on DSM cell cation currents....
In comparison to 9-phenanthrol, glibenclamide (100 muM) displayed lower inhibition of cation currents. ...This study advances …
9-Phenanthrol modulates postinhibitory rebound and afterhyperpolarizing potentials in an excitatory motor neuron of the medicinal leech.
Angstadt JD, Giordano JR, Goncalves AJ. Angstadt JD, et al. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2017 Aug;203(8):613-633. doi: 10.1007/s00359-017-1178-4. Epub 2017 May 11. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2017. PMID: 28497254
In vertebrates, I(CAN) is associated with TRPM4 channels which are blocked selectively by 9-phenanthrol. Here, we show that 9-phenanthrol selectively inhibits a late phase of PIR and simultaneously enhances afterhyperpolarizing potentials (AHPs). ...
In vertebrates, I(CAN) is associated with TRPM4 channels which are blocked selectively by 9-phenanthrol. Here, we show that …
135 results