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ZAPA, (Z)-3-[(aminoiminomethyl)thio]-2-propenoic acid hydrochloride, a potent agonist at GABA-receptors on the Ascaris muscle cell.
Holden-Dye L, Walker RJ. Holden-Dye L, et al. Br J Pharmacol. 1988 Sep;95(1):3-5. doi: 10.1111/j.1476-5381.1988.tb16540.x. Br J Pharmacol. 1988. PMID: 2851353 Free PMC article.
This study is the first report of a compound which is equal in efficacy to gamma-aminobutyric acid (GABA) at the nematode Ascaris muscle GABA-receptor. The GABA-receptor at the Ascaris muscle cell which mediates a membrane hyperpolarization and muscle relaxation has eluded …
This study is the first report of a compound which is equal in efficacy to gamma-aminobutyric acid (GABA) at the nematode Ascaris mus …
GABAA agonists as targets for drug development.
Johnston GA. Johnston GA. Clin Exp Pharmacol Physiol. 1992 Jan;19(1):73-8. doi: 10.1111/j.1440-1681.1992.tb00401.x. Clin Exp Pharmacol Physiol. 1992. PMID: 1320473 Review.
Analysis of GABA(A)- and GABA(B)-receptor mediated effects on intracellular Ca(2+) in DRG hybrid neurones.
Yokogawa T, Kim SU, Krieger C, Puil E. Yokogawa T, et al. Br J Pharmacol. 2001 Sep;134(1):98-107. doi: 10.1038/sj.bjp.0704244. Br J Pharmacol. 2001. PMID: 11522601 Free PMC article.
Using pharmacological analysis and fura-2 spectrofluorimetry, we examined the effects of gamma-aminobutyric acid (GABA) and related substances on intracellular Ca(2+) concentration ([Ca(2+)]i) of hybrid neurones, called MD3 cells. ...Pressure applications of GABA (100 micr …
Using pharmacological analysis and fura-2 spectrofluorimetry, we examined the effects of gamma-aminobutyric acid (GABA) and related s …
pH-dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor.
Matsuda K, Hosie AM, Buckingham SD, Squire MD, Baylis HA, Sattelle DB. Matsuda K, et al. Brain Res. 1996 Nov 11;739(1-2):335-8. doi: 10.1016/s0006-8993(96)00998-5. Brain Res. 1996. PMID: 8955956
The actions of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid) were tested on an ionotropic homo-oligomeric GABA receptor of Drosophila melanogaster. The amplitude of currents activated by THIP and ZAPA decline …
The actions of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid) were te …
Developmental regulation of regional functionality of substantial nigra GABAA receptors involved in seizures.
Velísková J, Velísek L, Nunes ML, Moshé SL. Velísková J, et al. Eur J Pharmacol. 1996 Aug 8;309(2):167-73. doi: 10.1016/0014-2999(96)00341-x. Eur J Pharmacol. 1996. PMID: 8874135
GABAergic (gamma-aminobutyric acid) transmission in the substantia nigra pars reticulata is critical for seizure control. ...In adult rats, we determined the effects on flurothyl seizures of (Z)-3-[(aminoiminomethyl)thio]prop-2-enoic acid (ZAPA, a presumed agonist o …
GABAergic (gamma-aminobutyric acid) transmission in the substantia nigra pars reticulata is critical for seizure control. ...In adult …
GABA(C) receptors in neuroendocrine gut cells: a new GABA-binding site in the gut.
Jansen A, Hoepfner M, Herzig KH, Riecken EO, Scherübl H. Jansen A, et al. Pflugers Arch. 2000 Dec;441(2-3):294-300. doi: 10.1007/s004240000412. Pflugers Arch. 2000. PMID: 11211116
For functional characterization, the effects of GABA(C) receptor activation on [Ca2+]i and hormone secretion were studied. The selective GABA(C) receptor agonist cis-4-aminocrotonic acid (CACA) induced dose-dependent increases both of [Ca2+]i and of hormone (cholecystokini …
For functional characterization, the effects of GABA(C) receptor activation on [Ca2+]i and hormone secretion were studied. The selective GAB …
Structural analogues of ZAPA as GABAA agonists.
Allan RD, Dickenson HW, Johnston GA, Kazlauskas R, Mewett KN. Allan RD, et al. Neurochem Int. 1997 Jun;30(6):583-91. doi: 10.1016/s0197-0186(96)00094-0. Neurochem Int. 1997. PMID: 9153000
Structural analogues of ZAPA, Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid, an isothiouronium analogue of GABA, are potent GABAA agonists as seen in the isolated guinea-pig ileum and in the facilitation of [3H]diazepam binding to rat brain membranes. ...
Structural analogues of ZAPA, Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid, an isothiouronium analogue of GABA, are potent GABAA ago …
13 results