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Comparative brain and plasma pharmacokinetics and anticancer activities of chlorambucil and melphalan in the rat.
Greig NH, Sweeney DJ, Rapoport SI. Greig NH, et al. Cancer Chemother Pharmacol. 1988;21(1):1-8. doi: 10.1007/BF00262729. Cancer Chemother Pharmacol. 1988. PMID: 3342460
Equimolar doses of chlorambucil and melphalan (both 10 mg/kg) were administered i.v. to anesthetized rats, and the plasma and brain concentrations of chlorambucil, its metabolites 3,4-dehydrochlorambucil and phenylacetic mustard, and melphalan were determined …
Equimolar doses of chlorambucil and melphalan (both 10 mg/kg) were administered i.v. to anesthetized rats, and the plasma and brain concentr …
Pharmacokinetics of chlorambucil-tertiary butyl ester, a lipophilic chlorambucil derivative that achieves and maintains high concentrations in brain.
Greig NH, Daly EM, Sweeney DJ, Rapoport SI. Greig NH, et al. Cancer Chemother Pharmacol. 1990;25(5):320-5. doi: 10.1007/BF00686230. Cancer Chemother Pharmacol. 1990. PMID: 2306791
Plasma and brain concentrations of chlorambucil and its active metabolites, 3,4-dehydrochlorambucil and phenylacetic mustard, as well as of chlorambucil-tertiary butyl ester were then determined by HPLC between 2 and 240 min after drug administration. ...
Plasma and brain concentrations of chlorambucil and its active metabolites, 3,4-dehydrochlorambucil and phenylacetic mu …