Enzymatic synthesis and phosphorolysis of 4(2)-thioxo- and 6(5)-azapyrimidine nucleosides by E. coli nucleoside phosphorylases.
Stepchenko VA, Miroshnikov AI, Seela F, Mikhailopulo IA.
Stepchenko VA, et al.
Beilstein J Org Chem. 2016 Dec 1;12:2588-2601. doi: 10.3762/bjoc.12.254. eCollection 2016.
Beilstein J Org Chem. 2016.
PMID: 28144328
Free PMC article.
Condensation of (2S)Ura and 5-azacytosine with dRib-1P (Ba salt) catalyzed by the accordant UP and PNP in TrisHCl buffer gave (2S)Ud and 2'-deoxy-5-azacytidine in 27% and 15% yields, respectively. 6-Azauracil and 6-azathymine showed good substrate properties for both TP and UP, w …
Condensation of (2S)Ura and 5-azacytosine with dRib-1P (Ba salt) catalyzed by the accordant UP and PNP in TrisHCl buffer gave (2S)Ud and 2'- …