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Page 1
A metabolite of carcinogenic 2-acetylaminofluorene, 2-nitrosofluorene, induces redox cycling in mitochondria.
Klöhn PC, Massalha H, Neumann HG. Klöhn PC, et al. Biochim Biophys Acta. 1995 May 10;1229(3):363-72. doi: 10.1016/0005-2728(95)00019-f. Biochim Biophys Acta. 1995. PMID: 7748887 Free article.
The present study was designed to confirm the recent proposal that 2-nitrosofluorene (2-NOF) as well as N-hydroxy-2-aminofluorene (N-OH-AF) induce a redox-cycle in rat liver mitochondria as part of the chronic toxic effects of the carcinogen 2-acetylaminofluorene (2 …
The present study was designed to confirm the recent proposal that 2-nitrosofluorene (2-NOF) as well as N-hydroxy-2-aminofluor …
Formation of glutathione adducts and 2-aminofluorene from 2-nitrosofluorene in postimplantation rat conceptuses in vitro.
Berberian RM, Eurich GE, Rios GA, Harris C. Berberian RM, et al. Reprod Toxicol. 1996 Jul-Aug;10(4):273-84. doi: 10.1016/0890-6238(96)00056-1. Reprod Toxicol. 1996. PMID: 8829250
The formation of glutathione (GSH) adducts and 2-aminofluorene (AF), GSH-derived metabolic products from 2-nitrosofluorene (NOF), was examined as a possible mechanism of GSH-mediated protection from NOF embryotoxicity in the gestational day 10 (GD 10) rat conceptus …
The formation of glutathione (GSH) adducts and 2-aminofluorene (AF), GSH-derived metabolic products from 2-nitrosofluorene (NO …
2-Nitrosofluorene and N-hydroxy-2-aminofluorene react with the ubiquinone-reduction center (center N) of the mitochondrial cytochrome bc1 complex.
Klöhn PC, Brandt U, Neumann HG. Klöhn PC, et al. FEBS Lett. 1996 Jul 8;389(3):233-7. doi: 10.1016/0014-5793(96)00592-3. FEBS Lett. 1996. PMID: 8766706 Free article.
We determined the sites of artificial electron transfer onto 2-nitrosofluorene (NOF), a metabolite of carcinogenic 2- acetylaminofluorene in mitochondria and isolated cytochrome bc1 complex. ...
We determined the sites of artificial electron transfer onto 2-nitrosofluorene (NOF), a metabolite of carcinogenic 2- acetylam …
Binding and mutagenicity studies with 2-nitrosofluorene on Salmonella typhimurium TA98 grown at different temperatures.
Hampton MJ, Floyd RA, Clark JB, Lancaster JH. Hampton MJ, et al. Mutat Res. 1980 Feb;69(2):231-9. doi: 10.1016/0027-5107(80)90088-3. Mutat Res. 1980. PMID: 6244486
The growth temperature of the histidine auxotroph Salmonella typhimurium TA98 influences the extent of binding of 2-nitrosofluorene (NOF) to this bacterium as well as the mutagenicity of this chemical carcinogen. ...
The growth temperature of the histidine auxotroph Salmonella typhimurium TA98 influences the extent of binding of 2-nitrosofluoren …
Formation and identification of glutathione conjugates from 2-nitrosofluorene and N-hydroxy-2-aminofluorene.
Mulder GJ, Unruh LE, Evans FE, Ketterer B, Kadlubar FF. Mulder GJ, et al. Chem Biol Interact. 1982 Mar 1;39(1):111-27. doi: 10.1016/0009-2797(82)90010-2. Chem Biol Interact. 1982. PMID: 7060218
2-Nitrosofluorene (NOF) and N-hydroxy-2-aminofluorene (N-HO-AF) are potent direct-acting mutagens, derived from metabolic activation of the carcinogen, N-acetyl-2-aminofluorene (AAF). ...
2-Nitrosofluorene (NOF) and N-hydroxy-2-aminofluorene (N-HO-AF) are potent direct-acting mutagens, derived from metabolic acti …
Peroxidative metabolism of carcinogenic N-arylhydroxamic acids: implications for tumorigenesis.
Malejka-Giganti D, Ritter CL. Malejka-Giganti D, et al. Environ Health Perspect. 1994 Oct;102 Suppl 6(Suppl 6):75-81. doi: 10.1289/ehp.94102s675. Environ Health Perspect. 1994. PMID: 7889863 Free PMC article. Review.
The metabolites formed in the presence of exogenous H2O2 are consistent with two peroxidative mechanisms: one electron-oxidation to a radical that dismutates to equimolar 2-nitrosofluorene (2-NOF) and the ester of the respective hydroxamic acid and halide-dependent …
The metabolites formed in the presence of exogenous H2O2 are consistent with two peroxidative mechanisms: one electron-oxidation to a radica …
The oxidation of 2-aminofluorene by prostaglandin endoperoxide synthetase. Comparison with other peroxidases.
Boyd JA, Harvan DJ, Eling TE. Boyd JA, et al. J Biol Chem. 1983 Jul 10;258(13):8246-54. J Biol Chem. 1983. PMID: 6408086 Free article.
The highly reactive oxygenated metabolites of 2-AF, N-hydroxy-2-AF, and 2-nitrosofluorene, are metabolized by prostaglandin endoperoxide synthetase to one major product, 2-nitrofluorene. The metabolism of 2-AF, N-hydroxy-2-AF, and 2-nitrosofluorene is …
The highly reactive oxygenated metabolites of 2-AF, N-hydroxy-2-AF, and 2-nitrosofluorene, are metabolized by prostaglandin en …
54 results