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Page 1
Initiation of hepatocarcinogenesis by endogenously formed N-nitrosobis(2-hydroxypropyl)amine, N-nitrosodiethanolamine and N-nitroso-2,6-dimethylmorpholine in rats.
Yamamoto K, Tsutsumi M, Kobayashi E, Endoh T, Noguchi O, Okajima E, Denda A, Mori Y, Konishi Y. Yamamoto K, et al. Carcinogenesis. 1995 Nov;16(11):2633-6. doi: 10.1093/carcin/16.11.2633. Carcinogenesis. 1995. PMID: 7586178
Initiation activities of endogenously formed N-nitrosobis(2-hydroxypropyl)amine (NBHPA), N-nitrosodiethanolamine (NDELA) and N-nitroso-2,6-dimethylmorpholine (NDMM) were investigated in a modified short-term assay for rat hepatocarcinogenesis. Male Wistar rat …
Initiation activities of endogenously formed N-nitrosobis(2-hydroxypropyl)amine (NBHPA), N-nitrosodiethanolamine (NDELA) and N-nitroso-2 …
Comparison of the carcinogenic effectiveness of N-nitrosobis(2-hydroxypropyl)amine, N-nitrosobis(2-oxopropyl)amine, N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine, and N-nitroso-2,6-dimethylmorpholine in Syrian hamsters.
Lijinsky W, Saavedra JE, Knutsen GL, Kovatch RM. Lijinsky W, et al. J Natl Cancer Inst. 1984 Mar;72(3):685-8. J Natl Cancer Inst. 1984. PMID: 6583451
For examination of metabolic interrelationships in carcinogenesis between N-nitroso-2,6-dimethylmorpholine, N-nitrosobis(2-oxopropyl)amine (CAS: 60599-38-4), N-nitrosobis(2-hydroxypropyl)amine (CAS: 53609-64-6), and N-nitroso(2-hydroxypropyl) (2-oxopropyl)ami …
For examination of metabolic interrelationships in carcinogenesis between N-nitroso-2,6-dimethylmorpholine, N-nitrosobi …
Metabolism of pancreatic carcinogens N-nitroso-2,6-dimethylmorpholine and N-nitrosobis(2-oxopropyl)amine by microsomes and cytosol of hamster pancreas and liver.
Kokkinakis DM, Scarpelli DG, Rao MS, Hollenberg PF. Kokkinakis DM, et al. Cancer Res. 1983 Dec;43(12 Pt 1):5761-7. Cancer Res. 1983. PMID: 6640529
Liver preparations from Syrian golden hamsters catalyze the metabolism of the pancreatic carcinogen N-nitroso-2,6-dimethylmorpholine largely to N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP). ...Pancreas, on the other hand, lacks the microsomal reductase …
Liver preparations from Syrian golden hamsters catalyze the metabolism of the pancreatic carcinogen N-nitroso-2,6-dimethylm …
Comparative metabolism of the cis and trans isomers of N-nitroso-2,6-dimethylmorpholine in rats, hamsters and guinea pigs.
Underwood B, Lijinsky W. Underwood B, et al. Chem Biol Interact. 1984 Jul;50(2):175-88. doi: 10.1016/0009-2797(84)90094-2. Chem Biol Interact. 1984. PMID: 6744463
The in vivo metabolism of the cis and trans isomers of N-[3,5-3H]nitroso-2,6-dimethylmorpholine (NDMM) was studied in female Fischer rats, Syrian golden hamsters and guinea pigs by analysis of urinary metabolites using high pressure liquid chromatography (HPL …
The in vivo metabolism of the cis and trans isomers of N-[3,5-3H]nitroso-2,6-dimethylmorpholine (NDMM) was studied in f …
The effect of N-nitroso-2-methoxy-2,6-dimethylmorpholine on endocrine and exocrine pancreas of Syrian hamsters.
Pour PM, Wallcave L, Nagel D. Pour PM, et al. Cancer Lett. 1981 Aug;13(3):233-40. doi: 10.1016/0304-3835(81)90023-9. Cancer Lett. 1981. PMID: 6271393
N-Nitroso-2-methoxy-2,6-dimethylmorpholine (MeNDMM), a cyclic derivative of the proposed proximate pancreatic carcinogen N-nitroso(2-hydroxypropyl) (2-oxopropyl)amine (HPOP), is shown to have an almost selective cytotoxic effect on pancreatic beta-cells when …
N-Nitroso-2-methoxy-2,6-dimethylmorpholine (MeNDMM), a cyclic derivative of the proposed proximate pancreatic carcinoge …
Metabolism and mutagenicity of N-nitroso-2-methoxy-2,6-dimethylmorpholine in hamsters.
Gingell R, Brunk G, Nagel D, Wallcave L, Walker B, Pour P. Gingell R, et al. J Natl Cancer Inst. 1980 Jan;64(1):157-61. J Natl Cancer Inst. 1980. PMID: 6928040
N-Nitroso-2-methoxy-2,6-dimethylmorpholine (MeNDMM) was derived from the cyclic form of N-nitroso-(2-hydroxypropyl)(2-oxopropyl)amine (HPOP), a proposed proximate pancreatic carcinogen for the hamster. ...
N-Nitroso-2-methoxy-2,6-dimethylmorpholine (MeNDMM) was derived from the cyclic form of N-nitroso-(2-hydroxypropyl)(2-o …
Metabolism of the cis and trans isomers of N-nitroso-2,6-dimethylmorpholine and their deuterated analogs by liver microsomes of rat and hamster.
Kokkinakis D, Hollenberg PF, Scarpelli DG. Kokkinakis D, et al. Carcinogenesis. 1984 Aug;5(8):1009-14. doi: 10.1093/carcin/5.8.1009. Carcinogenesis. 1984. PMID: 6744510
Liver microsomes from male Syrian golden hamsters and Sprague Dawley rats metabolize the cis and trans isomers of N-nitroso-2,6-dimethylmorpholine (NNDM) to N-nitroso-(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) as the major product detectable by h.p.l.c. ...
Liver microsomes from male Syrian golden hamsters and Sprague Dawley rats metabolize the cis and trans isomers of N-nitroso-2,6 …
Carcinogenic effect of N-nitroso-2,6-dimethylmorpholine in Syrian golden hamsters.
Reznik G, Mohr U, Lijinsky W. Reznik G, et al. J Natl Cancer Inst. 1978 Feb;60(2):371-8. doi: 10.1093/jnci/60.2.371. J Natl Cancer Inst. 1978. PMID: 202716
N-Nitroso-2,6-dimethylmorpholine was intragastrically administered to Syrian golden hamsters at four different dose levels [74 mg/kg body wt = 1/5 median lethal dose (LD50); 37 mg/kg body wt = 1/10 LD50; 18 mg/kg body wt = 1/20 LD50; and 9 mg/kg body wt = 1/4 …
N-Nitroso-2,6-dimethylmorpholine was intragastrically administered to Syrian golden hamsters at four different dose lev …
Comparison of carcinogenesis by two isomers of nitroso-2,6-dimethylmorpholine.
Lijinsky W, Reuber MD. Lijinsky W, et al. Carcinogenesis. 1980 Jun;1(6):501-3. doi: 10.1093/carcin/1.6.501. Carcinogenesis. 1980. PMID: 7273283
The cis and trans isomers of nitroso-2,6-dimethylmorpholine (Me2NMOR) have been separated and administered to Fischer 344 rats at doses corresponding to their proportion in the mixture prepared from the commercial amine (approximately 2 cis to 1 trans). ...
The cis and trans isomers of nitroso-2,6-dimethylmorpholine (Me2NMOR) have been separated and administered to Fischer 3 …
Carcinogenicity of N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine, N-nitrosobis(2-hydroxypropyl)amine and cis-N-nitroso-2,6-dimethylmorpholine administered continuously in the Syrian hamster, and the effect of dietary protein on N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine carcinogenesis.
Kokkinakis DM, Scarpelli DG. Kokkinakis DM, et al. Carcinogenesis. 1989 Apr;10(4):699-704. doi: 10.1093/carcin/10.4.699. Carcinogenesis. 1989. PMID: 2649266
The effect of continuous week-long administration of the three pancreatic carcinogens N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP), N-nitrosobis(2-hydroxypropyl)amine (BHP), and cis-N-nitroso-2,6-dimethylmorpholine (cis-NNDM), by a s.c. implanted osmot …
The effect of continuous week-long administration of the three pancreatic carcinogens N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP), N …
75 results